Search Results - "Szabo, Quentin"
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Higher-Order Chromosomal Structures Mediate Genome Function
Published in Journal of molecular biology (07-02-2020)“…How chromosomes are organized within the tridimensional space of the nucleus and how can this organization affect genome function have been long-standing…”
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Principles of genome folding into topologically associating domains
Published in Science advances (01-04-2019)“…Understanding the mechanisms that underlie chromosome folding within cell nuclei is essential to determine the relationship between genome structure and…”
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Multiscale 3D Genome Rewiring during Mouse Neural Development
Published in Cell (19-10-2017)“…Chromosome conformation capture technologies have revealed important insights into genome folding. Yet, how spatial genome architecture is related to gene…”
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Higher-Order Chromatin Organization Using 3D DNA Fluorescent In Situ Hybridization
Published in Methods in molecular biology (Clifton, N.J.) (2021)“…A comprehensive analysis of the tridimensional (3D) organization of the genome is crucial to understand gene regulation. Three-dimensional DNA fluorescent in…”
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Regulation of single-cell genome organization into TADs and chromatin nanodomains
Published in Nature genetics (01-11-2020)“…The genome folds into a hierarchy of three-dimensional structures within the nucleus. At the sub-megabase scale, chromosomes form topologically associating…”
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Stable Polycomb-dependent transgenerational inheritance of chromatin states in Drosophila
Published in Nature genetics (01-06-2017)“…Giacomo Cavalli, Frédéric Bantignies and colleagues report the establishment of stable and isogenic Drosophila lines carrying alternative epialleles, defined…”
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TADs are 3D structural units of higher-order chromosome organization in Drosophila
Published in Science advances (28-02-2018)“…Deciphering the rules of genome folding in the cell nucleus is essential to understand its functions. Recent chromosome conformation capture (Hi-C) studies…”
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Repression and 3D-restructuring resolves regulatory conflicts in evolutionarily rearranged genomes
Published in Cell (29-09-2022)“…Regulatory landscapes drive complex developmental gene expression, but it remains unclear how their integrity is maintained when incorporating novel genes and…”
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4D Genome Rewiring during Oncogene-Induced and Replicative Senescence
Published in Molecular cell (07-05-2020)“…To understand the role of the extensive senescence-associated 3D genome reorganization, we generated genome-wide chromatin interaction maps, epigenome,…”
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