Search Results - "Szabo, Peter A."

Single-cell transcriptomics of human T cells reveals tissue and activation signatures in health and disease by Szabo, Peter A., Levitin, Hanna Mendes, Miron, Michelle, Snyder, Mark E., Senda, Takashi, Yuan, Jinzhou, Cheng, Yim Ling, Bush, Erin C., Dogra, Pranay, Thapa, Puspa, Farber, Donna L., Sims, Peter A.

“…Human T cells coordinate adaptive immunity in diverse anatomic compartments through production of cytokines and effector molecules, but it is unclear how…”
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Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum by Weisberg, Stuart P., Connors, Thomas J., Zhu, Yun, Baldwin, Matthew R., Lin, Wen-Hsuan, Wontakal, Sandeep, Szabo, Peter A., Wells, Steven B., Dogra, Pranay, Gray, Joshua, Idzikowski, Emma, Stelitano, Debora, Bovier, Francesca T., Davis-Porada, Julia, Matsumoto, Rei, Poon, Maya Meimei Li, Chait, Michael, Mathieu, Cyrille, Horvat, Branka, Decimo, Didier, Hudson, Krystalyn E., Zotti, Flavia Dei, Bitan, Zachary C., La Carpia, Francesca, Ferrara, Stephen A., Mace, Emily, Milner, Joshua, Moscona, Anne, Hod, Eldad, Porotto, Matteo, Farber, Donna L.

“…Clinical manifestations of COVID-19 caused by the new coronavirus SARS-CoV-2 are associated with age 1 , 2 . Adults develop respiratory symptoms, which can…”
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Longitudinal profiling of respiratory and systemic immune responses reveals myeloid cell-driven lung inflammation in severe COVID-19 by Szabo, Peter A., Dogra, Pranay, Gray, Joshua I., Wells, Steven B., Connors, Thomas J., Weisberg, Stuart P., Krupska, Izabela, Matsumoto, Rei, Poon, Maya M.L., Idzikowski, Emma, Morris, Sinead E., Pasin, Chloé, Yates, Andrew J., Ku, Amy, Chait, Michael, Davis-Porada, Julia, Guo, Xinzheng V., Zhou, Jing, Steinle, Matthew, Mackay, Sean, Saqi, Anjali, Baldwin, Matthew R., Sims, Peter A., Farber, Donna L.

“…Immune response dynamics in coronavirus disease 2019 (COVID-19) and their severe manifestations have largely been studied in circulation. Here, we examined the…”
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Tissue adaptation and clonal segregation of human memory T cells in barrier sites by Poon, Maya M. L., Caron, Daniel P., Wang, Zicheng, Wells, Steven B., Chen, David, Meng, Wenzhao, Szabo, Peter A., Lam, Nora, Kubota, Masaru, Matsumoto, Rei, Rahman, Adeeb, Luning Prak, Eline T., Shen, Yufeng, Sims, Peter A., Farber, Donna L.

“…T lymphocytes migrate to barrier sites after exposure to pathogens, providing localized immunity and long-term protection. Here, we obtained blood and tissues…”
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MAIT cells launch a rapid, robust and distinct hyperinflammatory response to bacterial superantigens and quickly acquire an anergic phenotype that impedes their cognate antimicrobial function: Defining a novel mechanism of superantigen-induced immunopathology and immunosuppression by Shaler, Christopher R, Choi, Joshua, Rudak, Patrick T, Memarnejadian, Arash, Szabo, Peter A, Tun-Abraham, Mauro E, Rossjohn, Jamie, Corbett, Alexandra J, McCluskey, James, McCormick, John K, Lantz, Olivier, Hernandez-Alejandro, Roberto, Haeryfar, S M Mansour

“…Superantigens (SAgs) are potent exotoxins secreted by Staphylococcus aureus and Streptococcus pyogenes. They target a large fraction of T cell pools to set in…”
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SARS-CoV-2 infection generates tissue-localized immunological memory in humans by Poon, Maya M L, Rybkina, Ksenia, Kato, Yu, Kubota, Masaru, Matsumoto, Rei, Bloom, Nathaniel I, Zhang, Zeli, Hastie, Kathryn M, Grifoni, Alba, Weiskopf, Daniela, Wells, Steven B, Ural, Basak B, Lam, Nora, Szabo, Peter A, Dogra, Pranay, Lee, Yoon S, Gray, Joshua I, Bradley, Marissa C, Brusko, Maigan A, Brusko, Todd M, Saphire, Erica O, Connors, Thomas J, Sette, Alessandro, Crotty, Shane, Farber, Donna L

“…Adaptive immune responses to SARS-CoV-2 infection have been extensively characterized in blood; however, most functions of protective immunity must be…”
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Axes of heterogeneity in human tissue‐resident memory T cells by Szabo, Peter A.

“…Summary Tissue‐resident memory T cells (TRM) represent a dedicated layer of localized immune memory in virtually every organ throughout the human body. By…”
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CD1d- and MR1-Restricted T Cells in Sepsis by Szabo, Peter A, Anantha, Ram V, Shaler, Christopher R, McCormick, John K, Haeryfar, S M Mansour

“…Dysregulated immune responses to infection, such as those encountered in sepsis, can be catastrophic. Sepsis is typically triggered by an overwhelming systemic…”
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Location, location, location: Tissue resident memory T cells in mice and humans by Szabo, Peter A, Miron, Michelle, Farber, Donna L

“…The discovery of T cells resident in diverse tissues has altered our understanding of adaptive immunity to encompass site-specific responses mediated by…”
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Tissue Determinants of Human NK Cell Development, Function, and Residence by Dogra, Pranay, Rancan, Chiara, Ma, Wenji, Toth, Marta, Senda, Takashi, Carpenter, Dustin J., Kubota, Masaru, Matsumoto, Rei, Thapa, Puspa, Szabo, Peter A., Li Poon, Maya Meimei, Li, Jacky, Arakawa-Hoyt, Janice, Shen, Yufeng, Fong, Lawrence, Lanier, Lewis L., Farber, Donna L.

“…Immune responses in diverse tissue sites are critical for protective immunity and homeostasis. Here, we investigate how tissue localization regulates the…”
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Immune and epithelial determinants of age-related risk and alveolar injury in fatal COVID-19 by Chait, Michael, Yilmaz, Mine M, Shakil, Shanila, Ku, Amy W, Dogra, Pranay, Connors, Thomas J, Szabo, Peter A, Gray, Joshua I, Wells, Steven B, Kubota, Masaru, Matsumoto, Rei, Poon, Maya Ml, Snyder, Mark E, Baldwin, Matthew R, Sims, Peter A, Saqi, Anjali, Farber, Donna L, Weisberg, Stuart P

“…Respiratory failure in COVID-19 is characterized by widespread disruption of the lung's alveolar gas exchange interface. To elucidate determinants of alveolar…”
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Suppression of immunodominant antitumor and antiviral CD8+ T cell responses by indoleamine 2,3-dioxygenase by Rytelewski, Mateusz, Meilleur, Courtney E, Yekta, Maryam Atef, Szabo, Peter A, Garg, Nitan, Schell, Todd D, Jevnikar, Anthony M, Sharif, Shayan, Singh, Bhagirath, Haeryfar, S M Mansour

“…Indoleamine 2,3-dioxygenase (IDO) is a tryptophan-degrading enzyme known to suppress antitumor CD8(+) T cells (TCD8). The role of IDO in regulation of…”
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Microanatomical dissection of human intestinal T-cell immunity reveals site-specific changes in gut-associated lymphoid tissues over life by Senda, Takashi, Dogra, Pranay, Granot, Tomer, Furuhashi, Kazuhiro, Snyder, Mark E., Carpenter, Dustin J., Szabo, Peter A., Thapa, Puspa, Miron, Michelle, Farber, Donna L.

“…Defining adaptive immunity with the complex structures of the human gastrointestinal (GI) tract over life is essential for understanding immune responses to…”
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Inhaled particulate accumulation with age impairs immune function and architecture in human lung lymph nodes by Ural, Basak B., Caron, Daniel P., Dogra, Pranay, Wells, Steven B., Szabo, Peter A., Granot, Tomer, Senda, Takashi, Poon, Maya M. L., Lam, Nora, Thapa, Puspa, Lee, Yoon Seung, Kubota, Masaru, Matsumoto, Rei, Farber, Donna L.

“…Older people are particularly susceptible to infectious and neoplastic diseases of the lung and it is unclear how lifelong exposure to environmental pollutants…”
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Site-specific development and progressive maturation of human tissue-resident memory T cells over infancy and childhood by Connors, Thomas J, Matsumoto, Rei, Verma, Shivali, Szabo, Peter A, Guyer, Rebecca, Gray, Joshua, Wang, Zicheng, Thapa, Puspa, Dogra, Pranay, Poon, Maya M L, Rybkina, Ksenia, Bradley, Marissa C, Idzikowski, Emma, McNichols, James, Kubota, Masaru, Pethe, Kalpana, Shen, Yufeng, Atkinson, Mark A, Brusko, Maigan, Brusko, Todd M, Yates, Andrew J, Sims, Peter A, Farber, Donna L

“…Infancy and childhood are critical life stages for generating immune memory to protect against pathogens; however, the timing, location, and pathways for…”
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Heterogeneity of human anti-viral immunity shaped by virus, tissue, age, and sex by Poon, Maya M L, Byington, Eve, Meng, Wenzhao, Kubota, Masaru, Matsumoto, Rei, Grifoni, Alba, Weiskopf, Daniela, Dogra, Pranay, Lam, Nora, Szabo, Peter A, Ural, Basak Burcu, Wells, Steven B, Rosenfeld, Aaron M, Brusko, Maigan A, Brusko, Todd M, Connors, Thomas J, Sette, Alessandro, Sims, Peter A, Luning Prak, Eline T, Shen, Yufeng, Farber, Donna L

“…The persistence of anti-viral immunity is essential for protection and exhibits profound heterogeneity across individuals. Here, we elucidate the factors that…”
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Rapid and Rigorous IL-17A Production by a Distinct Subpopulation of Effector Memory T Lymphocytes Constitutes a Novel Mechanism of Toxic Shock Syndrome Immunopathology by Szabo, Peter A, Goswami, Ankur, Mazzuca, Delfina M, Kim, Kyoungok, O'Gorman, David B, Hess, David A, Welch, Ian D, Young, Howard A, Singh, Bhagirath, McCormick, John K, Haeryfar, S M Mansour

“…Toxic shock syndrome (TSS) is caused by staphylococcal and streptococcal superantigens (SAgs) that provoke a swift hyperinflammatory response typified by a…”
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Invariant Natural Killer T Cells Are Pathogenic in the HLA-DR4—Transgenic Humanized Mouse Model of Toxic Shock Syndrome and Can Be Targeted to Reduce Morbidity by Szabo, Peter A., Rudak, Patrick T., Choi, Joshua, Xu, Stacey X., Schaub, Robert, Singh, Bhagirath, McCormick, John K., Haeryfar, S. M. Mansour

“…During toxic shock syndrome (TSS), bacterial superantigens trigger a polyclonal T -cell response leading to a potentially catastrophic "cytokine storm."…”
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Superantigens subvert the neutrophil response to promote abscess formation and enhance Staphylococcus aureus survival in vivo by Xu, Stacey X, Gilmore, Kevin J, Szabo, Peter A, Zeppa, Joseph J, Baroja, Miren L, Haeryfar, S M Mansour, McCormick, John K

“…Staphylococcus aureus is a versatile bacterial pathogen that produces T cell-activating toxins known as superantigens (SAgs). Although excessive immune…”
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At-scale lift experiments modeling dragonfly forewings by Szabo, Peter A K, D'Eleuterio, Gabriele M T

“…An experimental investigation of the lift performance of an artificial platform at the scale of the dragonfly species Sympetrum sanguineum is presented. The…”
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