Search Results - "Szabados, Eve"

Rapid radioassay for metabolites of adenosine and deoxyadenosine in erythrocytes by Szabados, Eve, Christopherson, Richard I.

“…A radioassay has been developed to quantify the uptake and initial metabolism of adenosine (Ado) or deoxyadenosine (dAdo) by human erythrocytes. Cell…”
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Substrate channelling by human IMP synthase by Szabados, Eve, Christopherson, Richard I.

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Relationship between the catalytic sites of human bifunctional IMP synthase by Szabados, Eve, Christopherson, Richard I.

“…Background and Aims: The bifunctional enzyme, IMP synthase, contains 5-aminoimidazole-4-carboxamide ribotide (AICAR) transformylase and IMP cyclohydrolase…”
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Comparative effects of cladribine, fludarabine and pentostatin on nucleotide metabolism in T- and B-cell lines by Wilson, Paul K., Szabados, Eve, Mulligan, Stephen P., Christopherson, Richard I.

“…Background and aims: the purine nucleoside analogues cladribine (CdA), fludarabine (F-Ara-AMP) and pentostatin (dCf), are effective therapy for a range of T-…”
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5-Aminoimidazole-4-carboxamide ribotide transformylase-IMP cyclohydrolase from human CCRF-CEM leukemia cells: purification, pH dependence, and inhibitors by Szabados, Eve, Hindmarsh, Elizabeth J, Phillips, Leonidas, Duggleby, Ronald G, Christopherson, Richard I

“…The bifunctional enzyme 5-aminoimidazole-4-carboxamide ribotide (AICAR) transformylase-IMP cyclohydrolase has been purified 780-fold to apparent homogeneity…”
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Substrate channelling by human IMP synthase by Szabados, E, Wilson, P K, Christopherson, R I

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Inosine‐5′‐monophosphate analogues as inhibitors of human IMP cyclohydrolase and cellular growth by Szabados, Eve, Manthey, Michael K., Wilson, Paul K., Christopherson, Richard I.

“…The catalytic mechanism for the enzyme, IMP cyclohydrolase, may involve a reaction intermediate with negative charge in the 2‐position of the purine ring…”
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Metabolism of adenosine and deoxyadenosine by human erythrocytes and CCRF-CEM leukemia cells by Szabados, Eve, Duggleby, Ronald G., Christopherson, Richard I.

“…Human lymphocytes lacking adenosine deaminase die and T-cell leukemias are killed by deoxycoformycin (dCf), an inhibitor of adenosine deaminase, due to…”
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Mechanisms of Inhibition of Amido Phosphoribosyltransferase from Mouse L1210 Leukemia Cells by Schoettle, Sarah L, Crisp, Leesa B, Szabados, Eve, Christopherson, Richard I

“…Amido phosphoribosyltransferase (amido PRTase) catalyses the first step of the pathway for de novo biosynthesis of purine nucleotides. The enzyme is subject to…”
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Cytotoxic effects of dihydroorotase inhibitors upon human CCRF-CEM leukemia by BROOKE, J, SZABADOS, E, LYONS, S. D, GOODRIDGE, R. J, HARSANYI, M. C, POINER, A, CHRISTOPHERSON, R. I

“…6-L-Thiodihydroorotate (TDHO) and 2-oxo-1,2,3,6-tetrahydropyrimidine-4,6-dicarboxylate (HDDP) are potent inhibitors of mammalian dihydroorotase in vitro (R. I…”
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Mercaptan and dicarboxylate inhibitors of hamster dihydroorotase by Christopherson, Richard I, Schmalzl, Karl J, Szabados, Eve, Goodridge, Richard J, Harsanyi, Michael C, Sant, Melissa E, Algar, Elizabeth M, Anderson, Janet E, Armstrong, Alison

“…In mammals, dihydroorotase is part of a trifunctional protein, dihydroorotate synthetase, which catalyzes the first three reactions of de novo pyrimidine…”
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Dual effects of pyrazofurin and 3-deazauridine upon pyrimidine and purine biosynthesis in mouse L1210 leukemia by SANT, M. E, LYONS, S. D, KEMP, A. J, MCCLURE, L. K, SZABADOS, E, CHRISTOPHERSON, R. I

“…Pyrazofurin (NSC 143095) as the monophosphate derivative is a potent inhibitor of orotidine 5'-monophosphate (OMP) decarboxylase of the pyrimidine pathway and…”
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