Search Results - "Szállási, Z."

The comparison of thrombocytosis and platelet-lymphocyte ratio as potential prognostic markers in colorectal cancer by Baranyai, Z, Krzystanek, M, Jósa, V, Dede, K, Agoston, E, Szász, A M, Sinkó, D, Szarvas, V, Salamon, F, Eklund, A C, Szállási, Z, Jakab, F

“…The aim of the present study was to analyse the preoperative platelet count and the platelet-lymphocyte ratio (PLR) in patients with colorectal cancer (CRC) of…”
Get more information

Detecting mutant KRAS in liquid biopsies: a biomarker searching for a role by Szallasi, Z.

Get full text

Another surprising role for exosomes? Improving next-generation sequencing-based cancer diagnostics in liquid biopsies by Szallasi, Z.

Get full text

Sequenza: allele-specific copy number and mutation profiles from tumor sequencing data by Favero, F., Joshi, T., Marquard, A.M., Birkbak, N.J., Krzystanek, M., Li, Q., Szallasi, Z., Eklund, A.C.

“…Exome or whole-genome deep sequencing of tumor DNA along with paired normal DNA can potentially provide a detailed picture of the somatic mutations that…”
Get full text

Loss of BRCA1 or BRCA2 markedly increases the rate of base substitution mutagenesis and has distinct effects on genomic deletions by Zámborszky, J, Szikriszt, B, Gervai, J Z, Pipek, O, Póti, Á, Krzystanek, M, Ribli, D, Szalai-Gindl, J M, Csabai, I, Szallasi, Z, Swanton, C, Richardson, A L, Szüts, D

“…Loss-of-function mutations in the BRCA1 and BRCA2 genes increase the risk of cancer. Owing to their function in homologous recombination repair, much research…”
Get full text

Overexpression of BLM promotes DNA damage and increased sensitivity to platinum salts in triple-negative breast and serous ovarian cancers by Birkbak, N.J., Li, Y., Pathania, S., Greene-Colozzi, A., Dreze, M., Bowman-Colin, C., Sztupinszki, Z., Krzystanek, M., Diossy, M., Tung, N., Ryan, P.D., Garber, J.E., Silver, D.P., Iglehart, J.D., Wang, Z.C., Szuts, D., Szallasi, Z., Richardson, A.L.

“…Platinum-based therapy is an effective treatment for a subset of triple-negative breast cancer and ovarian cancer patients. In order to increase response rate…”
Get full text

Computational prediction of neoantigens: do we need more data or new approaches? by Eklund, A.C., Szallasi, Z.

Get full text

Reliability and reproducibility issues in DNA microarray measurements by Draghici, Sorin, Khatri, Purvesh, Eklund, Aron C., Szallasi, Zoltan

“…DNA microarrays enable researchers to monitor the expression of thousands of genes simultaneously. However, the current technology has several limitations…”
Get full text

Breast cancer brain metastases show increased levels of genomic aberration-based homologous recombination deficiency scores relative to their corresponding primary tumors by Diossy, M., Reiniger, L., Sztupinszki, Z., Krzystanek, M., Timms, K.M., Neff, C., Solimeno, C., Pruss, D., Eklund, A.C., Tóth, E., Kiss, O., Rusz, O., Cserni, G., Zombori, T., Székely, B., Kulka, J., Tímár, J., Csabai, I., Szallasi, Z.

“…Based on its mechanism of action, PARP inhibitor therapy is expected to benefit mainly tumor cases with homologous recombination deficiency (HRD). Therefore,…”
Get full text

SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair by Kanu, N, Grönroos, E, Martinez, P, Burrell, R A, Yi Goh, X, Bartkova, J, Maya-Mendoza, A, Mistrík, M, Rowan, A J, Patel, H, Rabinowitz, A, East, P, Wilson, G, Santos, C R, McGranahan, N, Gulati, S, Gerlinger, M, Birkbak, N J, Joshi, T, Alexandrov, L B, Stratton, M R, Powles, T, Matthews, N, Bates, P A, Stewart, A, Szallasi, Z, Larkin, J, Bartek, J, Swanton, C

“…Defining mechanisms that generate intratumour heterogeneity and branched evolution may inspire novel therapeutic approaches to limit tumour diversity and…”
Get full text

Deletion of the sep1+ Forkhead Transcription Factor Homologue Is Not Lethal but Causes Hyphal Growth in Schizosaccharomyces pombe by Ribár, B., Grallert, A., Oláh, É., Szállási, Z.

“…sep1+, the Schizosaccharomyces pombe homologue of the forkhead/HNF-3 transcription factors, plays a role in the cell separation at the end of mitosis. Its…”
Get full text

Comparison of the roles of the C1a and C1b domains of protein kinase C alpha in ligand induced translocation in NIH 3T3 cells by Bögi, K., Lorenzo, P.S., Ács, P., Szállási, Z., Wagner, G.S., Blumberg, P.M.

“…To explore the relative roles of the two C1 domains of protein kinase C alpha (PKCα) in the response to phorbol esters and related analogs, we mutated the…”
Get full text

Loss of BRCA1 or BRCA2 markedly increases the rate of base substitution mutagenesis and has distinct effects on genomic deletions by Zámborszky, J, Szikriszt, B, Gervai, J Z, Pipek, O, Póti, Á, Krzystanek, M, Ribli, D, Szalai-Gindl, J M, Csabai, I, Szallasi, Z, Swanton, C, Richardson, A L, Szüts, D

“…This corrects the article DOI: 10.1038/onc.2016.243…”
Get full text

Intratumoural evolutionary landscape of high-risk prostate cancer: the PROGENY study of genomic and immune parameters by Linch, M., Goh, G., Hiley, C., Shanmugabavan, Y., McGranahan, N., Rowan, A., Wong, Y.N.S., King, H., Furness, A., Freeman, A., Linares, J., Akarca, A., Herrero, J., Rosenthal, R., Harder, N., Schmidt, G., Wilson, G.A., Birkbak, N.J., Mitter, R., Dentro, S., Cathcart, P., Arya, M., Johnston, E., Scott, R., Hung, M., Emberton, M., Attard, G., Szallasi, Z., Punwani, S., Quezada, S.A., Marafioti, T., Gerlinger, M., Ahmed, H.U., Swanton, C.

“…Intratumoural heterogeneity (ITH) is well recognised in prostate cancer (PC), but its role in high-risk disease is uncertain. A prospective, single-arm,…”
Get full text

Fast and accurate mutation detection in whole genome sequences of multiple isogenic samples with IsoMut by Pipek, O, Ribli, D, Molnár, J, Póti, Á, Krzystanek, M, Bodor, A, Tusnády, G E, Szallasi, Z, Csabai, I, Szüts, D

“…Detection of somatic mutations is one of the main goals of next generation DNA sequencing. A wide range of experimental systems are available for the study of…”
Get full text

Proteomic analysis of brain metastatic lung adenocarcinoma reveals intertumoral heterogeneity and specific alterations associated with the timing of brain metastases by Woldmar, N., Schwendenwein, A., Kuras, M., Szeitz, B., Boettiger, K., Tisza, A., László, V., Reiniger, L., Bagó, A.G., Szállási, Z., Moldvay, J., Szász, A.M., Malm, J., Horvatovich, P., Pizzatti, L., Domont, G.B., Rényi-Vámos, F., Hoetzenecker, K., Hoda, M.A., Marko-Varga, G., Schelch, K., Megyesfalvi, Z., Rezeli, M., Döme, B.

“…Brain metastases are associated with considerable negative effects on patients’ outcome in lung adenocarcinoma (LADC). Here, we investigated the proteomic…”
Get full text

Glioblastoma adaptation traced through decline of an IDH1 clonal driver and macro-evolution of a double-minute chromosome by Favero, F., McGranahan, N., Salm, M., Birkbak, N.J., Sanborn, J.Z., Benz, S.C., Becq, J., Peden, J.F., Kingsbury, Z., Grocok, R.J., Humphray, S., Bentley, D., Spencer-Dene, B., Gutteridge, A., Brada, M., Roger, S., Dietrich, P.-Y., Forshew, T., Gerlinger, M., Rowan, A., Stamp, G., Eklund, A.C., Szallasi, Z., Swanton, C.

“…In a glioblastoma tumour with multi-region sequencing before and after recurrence, we find an IDH1 mutation that is clonal in the primary but lost at…”
Get full text

Corrigendum to: Breast cancer brain metastases show increased levels of genomic aberration-based homologous recombination deficiency scores relative to their corresponding primary tumors by Diossy, M., Reiniger, L., Sztupinszki, Z., Krzystanek, M., Timms, K.M., Neff, C., Solimeno, C., Pruss, D., Eklund, A.C., Tóth, E., Kiss, O., Rusz, O., Cserni, G., Zombori, T., Székely, B., Kulka, J., Tímár, J., Csabai, I., Szallasi, Z.

Get full text

Both the Catalytic and Regulatory Domains of Protein Kinase C Chimeras Modulate the Proliferative Properties of NIH 3T3 Cells by Ács, Péter, Wang, Qiming J., Bögi, Krisztina, Marquez, Adriana M., Lorenzo, Patricia S., Bı́ró, Tamás, Szállási, Zoltán, Mushinski, J. Frederic, Blumberg, Peter M.

“…Protein kinase C (PKC) isozymes exhibit important differences in terms of their regulation and biological functions. Not only may some PKC isoforms be active…”
Get full text

The Catalytic Domain of Protein Kinase C Chimeras Modulates the Affinity and Targeting of Phorbol Ester-induced Translocation by Ács, Péter, Bögi, Krisztina, Lorenzo, Patricia S., Marquez, Adriana M., Bı́ró, Tamás, Szállási, Zoltán, Blumberg, Peter M.

“…Emerging evidence suggests important differences among protein kinase C (PKC) isozymes in terms of their regulation and biological functions. PKC is regulated…”
Get full text