Search Results - "Syvaenen, A. C."

Quantification of polymerase chain reaction products by affinity-based hybrid collection by SYVANEN, A.-C, BENGTSTROM, M, TENHUNEN, J, SODERLUND, H

“…We have used oligonucleotides modified with biotin in the 5'-end as primers in the polymerase chain reaction (PCR)-amplification. This results in the synthesis…”
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Common and Low-Frequency Genetic Variants in the PCSK9 Locus Influence Circulating PCSK9 Levels by Chernogubova, Ekaterina, Strawbridge, Rona, Mahdessian, Hovsep, Mälarstig, Anders, Krapivner, Sergey, Gigante, Bruna, Hellénius, Mai-Lis, de Faire, Ulf, Franco-Cereceda, Anders, Syvänen, Ann-Christine, Troutt, Jason S, Konrad, Robert J, Eriksson, Per, Hamsten, Anders, van ’t Hooft, Ferdinand M

“…OBJECTIVE —Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a circulating protein that influences plasma low-density lipoprotein concentration and…”
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Interferon regulatory factor 5 (IRF5) gene variants are associated with multiple sclerosis in three distinct populations by Kristjansdottir, G, Sandling, J K, Bonetti, A, Roos, I M, Milani, L, Wang, C, Gustafsdottir, S M, Sigurdsson, S, Lundmark, A, Tienari, P J, Koivisto, K, Elovaara, I, Pirttilä, T, Reunanen, M, Peltonen, L, Saarela, J, Hillert, J, Olsson, T, Landegren, U, Alcina, A, Fernández, O, Leyva, L, Guerrero, M, Lucas, M, Izquierdo, G, Matesanz, F, Syvänen, A-C

“…IRF5 is a transcription factor involved both in the type I interferon and the toll-like receptor signalling pathways. Previously, IRF5 has been found to be…”
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Quantitative evaluation by minisequencing and microarrays reveals accurate multiplexed SNP genotyping of whole genome amplified DNA by Lovmar, Lovisa, Fredriksson, Mona, Liljedahl, Ulrika, Sigurdsson, Snaevar, Syvänen, Ann‐Christine

“…Whole genome amplification (WGA) procedures such as primer extension preamplification (PEP) or multiple displacement amplification (MDA) have the potential to…”
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Genetic analysis of Alzheimer's disease in the Uppsala Longitudinal Study of Adult Men by Giedraitis, Vilmantas, Kilander, Lena, Degerman-Gunnarsson, Malin, Sundelöf, Johan, Axelsson, Tomas, Syvänen, Ann-Christine, Lannfelt, Lars, Glaser, Anna

“…Genetic factors influencing common complex conditions have proven difficult to identify, and data from numerous investigations have provided incomplete…”
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Sex chromosome evolution and speciation in Ficedula flycatchers by Sætre, Glenn-Peter, Borge, Thomas, Lindroos, Katarina, Haavie, Jon, Sheldon, Ben C., Primmer, Craig, Syvänen, Ann-Christine

“…Speciation is the combination of evolutionary processes that leads to the reproductive isolation of different populations. We investigate the significance of…”
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From gels to chips: "Minisequencing" primer extension for analysis of point mutations and single nucleotide polymorphisms by Syv nen, Ann-Christine

“…In the minisequencing primer extension reaction, a DNA polymerase is used specifically to extend a primer that anneals immediately adjacent to the nucleotide…”
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Contribution of IKBKE and IFIH1 gene variants to SLE susceptibility by Wang, C, Ahlford, A, Laxman, N, Nordmark, G, Eloranta, M-L, Gunnarsson, I, Svenungsson, E, Padyukov, L, Sturfelt, G, Jönsen, A, Bengtsson, A A, Truedsson, L, Rantapää-Dahlqvist, S, Sjöwall, C, Sandling, J K, Rönnblom, L, Syvänen, A-C

“…The type I interferon system genes IKBKE and IFIH1 are associated with the risk of systemic lupus erythematosus (SLE). To identify the sequence variants that…”
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Digital gene expression profiling of primary acute lymphoblastic leukemia cells by Nordlund, J, Kiialainen, A, Karlberg, O, Berglund, E C, Göransson-Kultima, H, Sønderkær, M, Nielsen, K L, Gustafsson, M G, Behrendtz, M, Forestier, E, Perkkiö, M, Söderhäll, S, Lönnerholm, G, Syvänen, A-C

“…We determined the genome-wide digital gene expression (DGE) profiles of primary acute lymphoblastic leukemia (ALL) cells from 21 patients taking advantage of…”
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Variation in genes in the endothelin pathway and endothelium-dependent and endothelium-independent vasodilation in an elderly population by Lind, L., Syvänen, A.-C., Axelsson, T., Lundmark, P., Hägg, S., Larsson, A.

“…Aim Indirect evidences by blockade of the endothelin receptors have suggested a role of endothelin in endothelium‐dependent vasodilation. This study aimed to…”
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Time-resolved fluorometry: a sensitive method to quantify DNA-hybrids by Syvänen, Ann-Christine, Tchen, Paul, Ranki, Marjut, Söderlund, Hans

“…Europium and other lanthanides can be excitated with UV-radiation, whereafter the energy is released as fluorescence, delayed in time up to 1 ms after the…”
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Minisequencing on oligonucleotide microarrays: comparison of immobilisation chemistries by Lindroos, K, Liljedahl, U, Raitio, M, Syvänen, A C

“…In the microarray format of the minisequencing method multiple oligonucleotide primers immobilised on a glass surface are extended with fluorescent ddNTPs…”
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Variants of the TCF7L2 gene are associated with beta cell dysfunction and confer an increased risk of type 2 diabetes mellitus in the ULSAM cohort of Swedish elderly men by Dahlgren, A, Zethelius, B, Jensevik, K, Syvänen, A.-C, Berne, C

“…Aims/hypothesis In a population-based cohort of elderly men with well-defined phenotypes and biochemical markers related to type 2 diabetes mellitus, we…”
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Amount of introgression in flycatcher hybrid zones reflects regional differences in pre and post‐zygotic barriers to gene exchange by BORGE, T., LINDROOS, K., NÁDVORNÍK, P., SYVÄNEN, A. ‐C., SæTRE, G. ‐P.

“…Introgression is the incorporation of alleles from one species or semispecies into the gene pool of another through hybridization and backcrossing. The rate at…”
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Amplification of the hypervariable region close to the apolipoprotein B gene: application to forensic problems by Vuorio, A F, Sajantila, A, Hämäläinen, T, Syvänen, A C, Ehnholm, C, Peltonen, L

“…Our purpose was to identify individuals from blood stains in two murder cases. We used primers flanking the hypervariable region of the apoB gene to amplify…”
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Minisequencing: a specific tool for DNA analysis and diagnostics on oligonucleotide arrays by Pastinen, T, Kurg, A, Metspalu, A, Peltonen, L, Syvänen, A C

“…We describe a method for multiplex detection of mutations in which the solid-phase minisequencing principle is applied to an oligonucleotide array format. The…”
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Multiplex SNP genotyping in pooled DNA samples by a four‐colour microarray system by Lindroos, Katarina, Sigurdsson, Snaevar, Johansson, Karin, Rönnblom, Lars, Syvänen, Ann‐Christine

“…We selected 125 candidate single nucleotide polymorphisms (SNPs) in genes belonging to the human type 1 interferon (IFN) gene family and the genes coding for…”
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Defective endocytic trafficking of NPC1 and NPC2 underlying infantile Niemann–Pick type C disease by Blom, Titta S., Linder, Matts D., Snow, Karen, Pihko, Helena, Hess, Michael W., Jokitalo, Eija, Veckman, Ville, Syvänen, Ann-Christine, Ikonen, Elina

“…Niemann–Pick type C (NPC) disease is a fatal recessively inherited lysosomal cholesterol-sphingolipidosis. Mutations in the NPC1 gene cause ∼95% of the cases,…”
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Endothelium-dependent vasodilation in conduit and resistance vessels in relation to the endothelial nitric oxide synthase gene by Ingelsson, E, Syvänen, A-C, Lind, L

“…Single nucleotide polymorphisms (SNPs) in the endothelial nitric oxide synthase ( NOS3 ) gene have been related to endothelium-dependent vasodilation in either…”
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Linkage of familial combined hyperlipidaemia to chromosome 1q21-q23 by Pajukanta, Päivi, Nuotio, Ilpo, Terwilliger, Joseph D, Porkka, Kimmo V.K, Ylitalo, Kati, Pihlajamäki, Jussi, Suomalainen, Aki J, Syvänen, Ann-Christine, Lehtimäki, Terho, Viikari, Jorma S.A, Laakso, Markku, Taskinen, Marja-Riitta, Ehnholm, Christian, Peltonen, Leena

“…More than half of the patients with angiographically confirmed premature coronary heart disease (CHD) have a familial lipoprotein disorder. Familial combined…”
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