Search Results - "Sytkowski, Arthur J."

Erythropoietin and cancer: the unintended consequences of anemia correction by Debeljak, Nataša, Solár, Peter, Sytkowski, Arthur J

“…Until 1990, erythropoietin (EPO) was considered to have a single biological purpose and action, the stimulation of red blood cell growth and differentiation…”
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The erythropoietin receptor in normal and cancer tissues by Jelkmann, Wolfgang, Bohlius, Julia, Hallek, Michael, Sytkowski, Arthur J

“…Abstract The hormone erythropoietin (EPO) is essential for the survival, proliferation and differentiation of the erythrocytic progenitors. The EPO receptor…”
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Human selenium binding protein-1 (hSP56) is a negative regulator of HIF-1α and suppresses the malignant characteristics of prostate cancer cells by Jeong, Jee-Yeong, Zhou, Jin-Rong, Gao, Chong, Feldman, Laurie, Sytkowski, Arthur J

“…In the present study, we demonstrate that ectopic expression of 56-kDa human selenium binding protein-1 (hSP56) in PC-3 cells that do not normally express…”
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An Erythropoietin Autocrine/Paracrine Axis Modulates the Growth and Survival of Human Prostate Cancer Cells by Jeong, Jee-Yeong, Hoxhaj, Gerta, Socha, Amanda L, Sytkowski, Arthur J, Feldman, Laurie

“…Erythropoietin receptors have been identified on a variety of cancer-derived cell lines and primary cancer cells, including those of prostate cancer. The…”
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Variability in the immunodetection of His-tagged recombinant proteins by Debeljak, Nataša, Feldman, Laurie, Davis, Kerry L., Komel, Radovan, Sytkowski, Arthur J.

“…Labeling of recombinant proteins with polypeptide fusion partners, or affinity tagging, is a useful method to facilitate subsequent protein purification and…”
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Differentially expressed genes associated with cisplatin resistance in human ovarian adenocarcinoma cell line A2780 by Solár, Peter, Sytkowski, Arthur J

“…Abstract Ovarian cancer cells are usually initially sensitive to platinum-based chemotherapy, such as cisplatin (CDDP), but typically become resistant over…”
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Erythropoietin inhibits apoptosis induced by photodynamic therapy in ovarian cancer cells by Solár, Peter, Koval, Ján, Mikes, Jaromír, Kleban, Ján, Solárová, Zuzana, Lazúr, Ján, Hodorová, Ingrid, Fedorocko, Peter, Sytkowski, Arthur J

“…Recombinant human erythropoietin is widely used to treat anemia associated with cancer and with the myelosuppressive effects of chemotherapy, particularly…”
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Human selenium binding protein-1 (hSP56) interacts with VDU1 in a selenium-dependent manner by Jeong, Jee-Yeong, Wang, Yuxun, Sytkowski, Arthur J.

“…Reduced expression of the 56-kDa human selenium binding protein-1 (hSP56) has been reported in many types of human malignancies, including prostate, lung,…”
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Erythropoietin regulation of Raf-1 and MEK: evidence for a Ras-independent mechanism by Chen, Changmin, Sytkowski, Arthur J.

“…Stimulation of the erythropoietin (EPO) receptor triggers a cascade of signaling events. We reported that EPO upregulates c-myc expression through 2 pathways…”
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Human selenium binding protein-1 (hSP56) is a negative regulator of HIF-1α and suppresses the malignant characteristics of prostate cancer cells by Jeong, Jee-Yeong, Zhou, Jin-Rong, Gao, Chong, Feldman, Laurie, Sytkowski, Arthur J

“…In the present study, we demonstrate that ectopic expression of 56-kDa human selenium binding protein-1 (hSP56) in PC-3 cells that do not normally express…”
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The Neurobiology of Erythropoietin by Sytkowski, Arthur J.

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Characterization of erythropoietin receptor and erythropoietin expression and function in human ovarian cancer cells by Jeong, Jee‐Yeong, Feldman, Laurie, Solar, Peter, Szenajch, Jolanta, Sytkowski, Arthur J.

“…The identification of erythropoietin receptors (EpoR) on cancer cells has caused concern, since it implies the possibility that treatment of cancer patients…”
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Erythropoietin and erythropoiesis stimulating agents by Debeljak, Nataša, Sytkowski, Arthur J.

“…Erythropoietin (EPO) is the main hormonal regulator of red blood cell production. Recombinant EPO has become the leading drug for treatment of anaemia from a…”
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Human Erythropoietin Dimers with Markedly Enhanced in vivo Activity by Sytkowski, Arthur J., Lunn, Elizabeth Dotimas, Davis, Kerry Lynn, Feldman, Laurie, Siekman, Suvia

“…Human erythropoietin, a widely used and important therapeutic glycoprotein, has a relatively short plasma half-life due to clearance by glomerular filtration…”
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Erythropoietin stimulates growth and STAT5 phosphorylation in human prostate epithelial and prostate cancer cells by Feldman, Laurie, Wang, Yuxun, Rhim, Johng S., Bhattacharya, Nandita, Loda, Massimo, Sytkowski, Arthur J.

“…BACKGROUND Erythropoietin (Epo), the principal regulator of erythroid progenitor survival, growth, and differentiation, initiates its action by binding to its…”
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Erythropoietin treatment of human ovarian cancer cells results in enhanced signaling and a paclitaxel‐resistant phenotype by Solar, Peter, Feldman, Laurie, Jeong, Jee‐Yeong, Busingye, Jacqueline R., Sytkowski, Arthur J.

“…Erythropoietin (Epo), a glycoprotein hormone that is the principal regulator of erythropoiesis, is known to act also on nonhematopoietic cell types. Epo…”
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Human erythropoietin increases the pro-angiogenic potential of A2780 ovarian adenocarcinoma cells under hypoxic conditions by KRIŠKA, JÁN, SOLÁR, PETER, VARINSKÁ, LENKA, SOLÁROVÁ, ZUZANA, KIMÁKOVÁ, PATRÍCIA, MOJŽIŠ, JÁN, FEDOROČKO, PETER, SYTKOWSKI, ARTHUR J

“…Erythropoietin (Epo) is a key regulator of erythroid cell proliferation, differentiation and apoptosis. In the form of the recombinant protein, it is widely…”
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Pleiotrophic Actions of Erythropoietin by FELDMAN, Laurie, SYTKOWSKI, Arthur J

“…Abstract Erythropoietin is the prime regulator of red blood cell production. However, recent evidence suggests that the hormone has multiple effects outside…”
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Location and the functionality of erythropoietin receptor(s) in A2780 cells by SOLAR, Peter, HRCKOVA, Gabriela, VARINSKA, Lenka, SOLAROVA, Zuzana, KRISKA, Ján, UHRINOVA, Ivana, KELLO, Martin, MOJZIS, Ján, FEDOROCKO, Peter, SYTKOWSKI, Arthur J

“…Erythropoietin (Epo) is a critical regulator of erythroid cell proliferation, differentiation and apoptosis. In the form of a recombinant protein, it is widely…”
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Apoptosis-linked gene-2 connects the Raf-1 and ASK1 signalings by Chen, Changmin, Sytkowski, Arthur J.

“…Raf-1 plays important roles in cell proliferation, differentiation, and survival. However, the unique and essential function of Raf-1 is anti-apoptotic. The…”
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