Search Results - "Synold, T."

Phase I study of the halichondrin B analogue eribulin mesylate in combination with cisplatin in advanced solid tumors by Koczywas, M, Frankel, P H, Synold, T W, Lenz, H-J, Mortimer, J E, El-Khoueiry, A B, Gandara, D R, Cristea, M C, Chung, V M, Lim, D, Reckamp, K L, Lau, D H, Doyle, L A, Ruel, C, Carroll, M I, Newman, E M

“…Background: Eribulin mesylate is a synthetic macrocyclic ketone analogue of Halichondrin B that has demonstrated high antitumor activity in preclinical and…”
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Pharmacogenetic analysis of paclitaxel transport and metabolism genes in breast cancer by Marsh, S, Somlo, G, Li, X, Frankel, P, King, C R, Shannon, W D, McLeod, H L, Synold, T W

“…Paclitaxel is commonly used in the treatment of breast cancer. Variability in paclitaxel clearance may contribute to the unpredictability of clinical outcomes…”
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Neural stem cell-mediated CE/CPT-11 enzyme/prodrug therapy in transgenic mouse model of intracerebellar medulloblastoma by Gutova, M, Shackleford, G M, Khankaldyyan, V, Herrmann, K A, Shi, X-H, Mittelholtz, K, Abramyants, Y, Blanchard, M S, Kim, S U, Annala, A J, Najbauer, J, Synold, T W, D'Apuzzo, M, Barish, M E, Moats, R A, Aboody, K S

“…Medulloblastoma is a heterogeneous diffuse neoplasm that can be highly disseminated, and is the most common malignant childhood brain tumor. Although…”
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Phase I trial of continuous infusion 5-aza-2'-deoxycytidine by APARICIO, A, EADS, C. A, LEONG, L. A, LAIRD, P. W, NEWMAN, E. M, SYNOLD, T. W, BAKER, S. D, ZHAO, M, WEBER, J. S

“…To identify a dose of the demethylating agent 5-aza-2'-deoxycytidine (DAC) with acceptable side effects, and to study its effect on the methylation patterns of…”
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A phase I study of bortezomib and temozolomide in patients with advanced solid tumors by Portnow, J., Frankel, P., Koehler, S., Twardowski, P., Shibata, S., Martel, C., Morgan, R., Cristea, M., Chow, W., Lim, D., Chung, V., Reckamp, K., Leong, L., Synold, T. W.

“…Purpose The primary objective was to determine the maximum tolerated doses (MTDs) of the combination of bortezomib and temozolomide in patients with solid…”
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A phase 1 trial dose-escalation study of tipifarnib on a week-on, week-off schedule in relapsed, refractory or high-risk myeloid leukemia by Kirschbaum, M H, Synold, T, Stein, A S, Tuscano, J, Zain, J M, Popplewell, L, Karanes, C, O'Donnell, M R, Pulone, B, Rincon, A, Wright, J, Frankel, P, Forman, S J, Newman, E M

“…Inhibition of farnesyltransferase (FT) activity has been associated with in vitro and in vivo anti-leukemia activity. We report the results of a phase 1…”
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The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux by Forman, Barry Marc, Synold, Timothy W, Dussault, Isabelle

“…Cytochrome P450 3A4 is an important mediator of drug catabolism that can be regulated by the steroid and xenobiotic receptor (SXR). We show here that SXR also…”
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Phase-2 trial of an intensified conditioning regimen for allogeneic hematopoietic cell transplant for poor-risk leukemia by Stein, A S, O'Donnell, M R, Synold, T W, Dagis, A C, Tsirunyan, A, Nademanee, A P, Parker, P M, Pullarkat, V A, Snyder, D S, Spielberger, R T, Wong, J Y C, Alvarnas, J C, Thomas, S H, Forman, S J

“…Patients with poor-risk leukemia have a high relapse rate despite allogeneic transplant. We report on the phase-2 trial of an intensified allogeneic transplant…”
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Peptide Mimetic HIV Protease Inhibitors Are Ligands for the Orphan Receptor SXR by Dussault, Isabelle, Lin, Min, Hollister, Kevin, Wang, Eric H., Synold, Timothy W., Forman, Barry Marc

“…The orphan nuclear receptor SXR coordinately regulates drug clearance in response to a wide variety of xenobiotic compounds. This signaling system protects the…”
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G-to-T Transversions and Small Tandem Base Deletions Are the Hallmark of Mutations Induced by Ultraviolet A Radiation in Mammalian Cells by Besaratinia, Ahmad, Synold, Timothy W, Xi, Bixin, Pfeifer, Gerd P

“…Ultraviolet A (UVA) radiation received from the sun and from the widespread use of tanning beds by populations residing in areas of northern latitude…”
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Accumulation of methotrexate polyglutamates in lymphoblasts is a determinant of antileukemic effects in vivo. A rationale for high-dose methotrexate by Masson, E, Relling, M V, Synold, T W, Liu, Q, Schuetz, J D, Sandlund, J T, Pui, C H, Evans, W E

“…Methotrexate (MTX) is one of the most widely used drugs for the treatment of childhood acute lymphoblastic leukemia (ALL) and is commonly given in high doses…”
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423 Phase 1 dose escalation, safety and pharmacokinetic study of IT-101 (CRLX101), a novel nanopharmaceutical containing camptothecin, in advanced solid tumor cancer patients by Yen, Y, Synold, T, Weiss, G.J, Schluep, T, Ryan, J

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661 A pharmacokinetic, pharmacodynamic and electrocardiographic study of L-MTP-PE in healthy volunteers by Venkatakrishnan, K, Kramer, W.G, Synold, T, Goodman, D.B, Oliva, C

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Similar Mutagenicity of Photoactivated Porphyrins and Ultraviolet A Radiation in Mouse Embryonic Fibroblasts:  Involvement of Oxidative DNA Lesions in Mutagenesis by Besaratinia, Ahmad, Bates, Steven E, Synold, Timothy W, Pfeifer, Gerd P

“…Ultraviolet A (UVA) radiation is implicated in the etiology of human skin cancer. However, the underlying mechanism of carcinogenicity for UVA is not fully…”
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Baicalin increases VEGF expression and angiogenesis by activating the ERR{alpha}/PGC-1{alpha} pathway by Zhang, Keqiang, Lu, Jianming, Mori, Taisuke, Smith-Powell, Leslie, Synold, Timothy W, Chen, Shiuan, Wen, Wei

“…Baicalin is the major component found in Scutellaria baicalensis root, a widely used herb in traditional Chinese medicine. Although it has been used for…”
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Pharmacokinetic and Pharmacodynamic Evaluation of the Glycinamide Ribonucleotide Formyltransferase Inhibitor AG2034 by MCLEOD, H. L, CASSIDY, J, COLLIER, M. A, PARADISO, L. J, ROBERTS, J. D, POWRIE, R. H, PRIEST, D. G, ZORBAS, M. A, SYNOLD, T. W, SHIBATA, S, SPICER, D, BISSETT, D, PITHAVALA, Y. K

“…Glycinamide ribonucleotide formyltransferase (GARFT) is a component of the de novo purine synthesis pathway. AG2034 is a specific inhibitor of GARFT that was…”
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Evaluation of 9-dimethylaminomethyl-10-hydroxycamptothecin against xenografts derived from adult and childhood solid tumors by HOUGHTON, P. J, CHESHIRE, P. J, MYERS, L, STEWART, C. F, SYNOLD, T. W, HOUGHTON, J. A

“…The topoisomerase I inhibitor 9-dimethylaminomethyl-10-hydroxycamptothecin (topotecan) was evaluated against a panel of xenografts comprising four lines of…”
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Phase II trial of carboplatin and infusional cyclosporine with alpha-interferon in recurrent ovarian cancer: a California Cancer Consortium Trial by Morgan, Jr, R J, Synold, T W, Gandara, D, Muggia, F, Scudder, S, Reed, E, Margolin, K, Raschko, J, Leong, L, Shibata, S, Tetef, M, Vasilev, S, McGonigle, K, Longmate, J, Yen, Y, Chow, W, Somlo, G, Carroll, M, Doroshow, J H

“…The purpose of this study was to estimate the response rate of 26-h continuous infusion cyclosporine A (CSA) combined with carboplatin (CBDCA) and subcutaneous…”
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Trial in Progress: CTEP 10492, A Phase 1/1b Study of the AKT Inhibitor Ipatasertib with Chemoradiation for Locally Advanced Head and Neck Squamous Cell Carcinoma by Mattes, M.D., Willers, H., Lin, Y., Gharzai, L.A., Alesi, E., Lominska, C.E., Kim, S., Haigentz, M., Kaur, V., Arnold, S., Synold, T., Gutkind, J.S., Wirth, L., Hanker, A., Said, R., Siu, L.L., Jabbour, S.K.

“…Locally advanced head and neck squamous cell carcinoma (HNSCC) is commonly treated with definitive chemoradiation therapy (CRT). However, locoregional…”
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High-dose paclitaxel in combination with doxorubicin, cyclophosphamide and peripheral blood progenitor cell rescue in patients with high-risk primary and responding metastatic breast carcinoma: toxicity profile, relationship to paclitaxel pharmacokinetics and short-term outcome by SOMLO, G, DOROSHOW, J. H, RASCHKO, J. W, SHIBATA, S. I, TETEF, M. L, YEN, Y, KOGUT, N, SCHRIBER, J, ALVARNAS, J, SYNOLD, T, LONGMATE, J, REARDON, D, CHOW, W, FORMAN, S. J, LEONG, L. A, MARGOLIN, K. A, MORGAN, R. J

“…We assessed the feasibility and pharmacokinetics of high-dose infusional paclitaxel in combination with doxorubicin, cyclophosphamide, and peripheral blood…”
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