Search Results - "Symons, Julian A"

Initiation, extension, and termination of RNA synthesis by a paramyxovirus polymerase by Jordan, Paul C, Liu, Cheng, Raynaud, Pauline, Lo, Michael K, Spiropoulou, Christina F, Symons, Julian A, Beigelman, Leo, Deval, Jerome

“…Paramyxoviruses represent a family of RNA viruses causing significant human diseases. These include measles virus, the most infectious virus ever reported, in…”
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The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir by Jochmans, Dirk, Liu, Cheng, Donckers, Kim, Stoycheva, Antitsa, Boland, Sandro, Stevens, Sarah K, De Vita, Chloe, Vanmechelen, Bert, Maes, Piet, Trüeb, Bettina, Ebert, Nadine, Thiel, Volker, De Jonghe, Steven, Vangeel, Laura, Bardiot, Dorothée, Jekle, Andreas, Blatt, Lawrence M, Beigelman, Leonid, Symons, Julian A, Raboisson, Pierre, Chaltin, Patrick, Marchand, Arnaud, Neyts, Johan, Deval, Jerome, Vandyck, Koen

“…The SARS-CoV-2 main protease (3CLpro) has an indispensable role in the viral life cycle and is a therapeutic target for the treatment of COVID-19. The…”
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Lumicitabine, an orally administered nucleoside analog, in infants hospitalized with respiratory syncytial virus (RSV) infection: Safety, efficacy, and pharmacokinetic results by Oey, Abbie, McClure, Matthew, Symons, Julian A, Chanda, Sushmita, Fry, John, Smith, Patrick F, Luciani, Kathia, Fayon, Michael, Chokephaibulkit, Kulkanya, Uppala, Rattapon, Bernatoniene, Jolanta, Furuno, Kenji, Stanley, Thorsten, Huntjens, Dymphy, Witek, James

“…Respiratory syncytial virus (RSV) infection is the leading cause of infant hospitalizations and mortality. Lumicitabine, an oral nucleoside analog was studied…”
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Evaluation of SARS-CoV-2 3C-like protease inhibitors using self-assembled monolayer desorption ionization mass spectrometry by Gurard-Levin, Zachary A., Liu, Cheng, Jekle, Andreas, Jaisinghani, Ruchika, Ren, Suping, Vandyck, Koen, Jochmans, Dirk, Leyssen, Pieter, Neyts, Johan, Blatt, Lawrence M., Beigelman, Leonid, Symons, Julian A., Raboisson, Pierre, Scholle, Michael D., Deval, Jerome

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the COVID-19 pandemic that began in 2019. The coronavirus 3-chymotrypsin-like…”
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Discovery of 4′-Chloromethyl-2′-deoxy-3′,5′-di‑O‑isobutyryl-2′-fluorocytidine (ALS-8176), A First-in-Class RSV Polymerase Inhibitor for Treatment of Human Respiratory Syncytial Virus Infection by Wang, Guangyi, Deval, Jerome, Hong, Jin, Dyatkina, Natalia, Prhavc, Marija, Taylor, Joshua, Fung, Amy, Jin, Zhinan, Stevens, Sarah K, Serebryany, Vladimir, Liu, Jyanwei, Zhang, Qingling, Tam, Yuen, Chanda, Sushmita M, Smith, David B, Symons, Julian A, Blatt, Lawrence M, Beigelman, Leo

“…Respiratory syncytial virus (RSV) is a leading pathogen of childhood and is associated with significant morbidity and mortality. To date, ribavirin is the only…”
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Regulation of gene transcription by thyroid hormone receptor β agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH) by Luong, Xuan G, Stevens, Sarah K, Jekle, Andreas, Lin, Tse-I, Gupta, Kusum, Misner, Dinah, Chanda, Sushmita, Mukherjee, Sucheta, Williams, Caroline, Stoycheva, Antitsa, Blatt, Lawrence M, Beigelman, Leonid N, Symons, Julian A, Raboisson, Pierre, McGowan, David, Vandyck, Koen, Deval, Jerome

“…Thyroid hormones are important modulators of metabolic activity in mammals and alter cholesterol and fatty acid levels through activation of the nuclear…”
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Structure-activity relationship analysis of mitochondrial toxicity caused by antiviral ribonucleoside analogs by Jin, Zhinan, Kinkade, April, Behera, Ishani, Chaudhuri, Shuvam, Tucker, Kathryn, Dyatkina, Natalia, Rajwanshi, Vivek K., Wang, Guangyi, Jekle, Andreas, Smith, David B., Beigelman, Leo, Symons, Julian A., Deval, Jerome

“…Recent cases of severe toxicity during clinical trials have been associated with antiviral ribonucleoside analogs (e.g. INX-08189 and balapiravir). Some have…”
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Tumor Regression upon Intratumoral and Subcutaneous Dosing of the STING Agonist ALG-031048 in Mouse Efficacy Models by Jekle, Andreas, Thatikonda, Santosh Kumar, Jaisinghani, Ruchika, Ren, Suping, Kinkade, April, Stevens, Sarah K, Stoycheva, Antitsa, Rajwanshi, Vivek K, Williams, Caroline, Deval, Jerome, Mukherjee, Sucheta, Zhang, Qingling, Chanda, Sushmita, Smith, David B, Blatt, Lawrence M, Symons, Julian A, Gonzalvez, Francois, Beigelman, Leonid

“…Stimulator of interferon genes (STING) agonists have shown potent anti-tumor efficacy in various mouse tumor models and have the potential to overcome…”
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Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate by Deval, Jerome, Hong, Jin, Wang, Guangyi, Taylor, Josh, Smith, Lucas K, Fung, Amy, Stevens, Sarah K, Liu, Hong, Jin, Zhinan, Dyatkina, Natalia, Prhavc, Marija, Stoycheva, Antitsa D, Serebryany, Vladimir, Liu, Jyanwei, Smith, David B, Tam, Yuen, Zhang, Qingling, Moore, Martin L, Fearns, Rachel, Chanda, Sushmita M, Blatt, Lawrence M, Symons, Julian A, Beigelman, Leo

“…Respiratory syncytial virus (RSV) causes severe lower respiratory tract infections, yet no vaccines or effective therapeutics are available. ALS-8176 is a…”
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Innovation and trends in the development and approval of antiviral medicines: 1987–2017 and beyond by Chaudhuri, Shuvam, Symons, Julian A., Deval, Jerome

“…2017 marked the 30th anniversary of the approval of zidovudine (AZT) as the first HIV/AIDS therapy. Since then, more than eighty antiviral drugs have received…”
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Antiviral Activity, Safety, and Pharmacokinetics of AL-794, a Novel Oral Influenza Endonuclease Inhibitor: Results of an Influenza Human Challenge Study by Yogaratnam, Jeysen, Rito, Jennifer, Kakuda, Thomas N, Fennema, Hein, Gupta, Kusum, Jekle, C Andreas, Mitchell, Toni, Boyce, Malcolm, Sahgal, Omair, Balaratnam, Ganesh, Chanda, Sushmita, Van Remoortere, Pieter, Symons, Julian A, Fry, John

“…A phase 2, double-blinded, randomized, viral challenge study was conducted to evaluate the antiviral activity of AL-794 in healthy volunteers. AL-794 at doses…”
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Biochemical Effect of Resistance Mutations against Synergistic Inhibitors of RSV RNA Polymerase by Deval, Jerome, Fung, Amy, Stevens, Sarah K, Jordan, Paul C, Gromova, Tatiana, Taylor, Joshua S, Hong, Jin, Meng, Jia, Wang, Guangyi, Dyatkina, Natalia, Prhavc, Marija, Symons, Julian A, Beigelman, Leo

“…ALS-8112 is the parent molecule of ALS-8176, a first-in-class nucleoside analog prodrug effective in the clinic against respiratory syncytial virus (RSV)…”
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Mechanism of action of hepatitis B virus S antigen transport-inhibiting oligonucleotide polymer, STOPS, molecules by Kao, C. Cheng, Nie, Yuchun, Ren, Suping, De Costa, N. Tilani T.S., Pandey, Rajendra K., Hong, Jin, Smith, David B., Symons, Julian A., Beigelman, Leonid, Blatt, Lawrence M.

“…A functional cure of chronic hepatitis B requires eliminating the hepatitis B virus (HBV)-encoded surface antigen (HBsAg), which can suppress immune responses…”
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A46R and A52R from Vaccinia Virus Are Antagonists of Host IL-1 and Toll-Like Receptor Signaling by Bowie, Andrew, Kiss-Toth, Endre, Symons, Julian A., Smith, Geoffrey L., Dower, Steven K., O'Neill, Luke A. J.

“…Poxviruses employ many strategies to evade and neutralize the host immune response. In this study, we have identified two vaccinia virus ORFs, termed A46R and…”
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Effects of a Polymorphism in the Human Tumor Necrosis Factor α Promoter on Transcriptional Activation by Wilson, Anthony G., Symons, Julian A., McDowell, Tarra L., McDevitt, Hugh O., Duff, Gordon W.

“…Tumor necrosis factor α (TNFα ) is a potent immunomodulator and proinflammatory cytokine that has been implicated in the pathogenesis of autoimmune and…”
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Activity of Oral ALS-008176 in a Respiratory Syncytial Virus Challenge Study by DeVincenzo, John P, McClure, Matthew W, Symons, Julian A, Fathi, Hosnieh, Westland, Christopher, Chanda, Sushmita, Lambkin-Williams, Rob, Smith, Patrick, Zhang, Qingling, Beigelman, Leo, Blatt, Lawrence M, Fry, John

“…There are limited treatment options for infection with the respiratory syncytial virus. In this human challenge model, a new oral nucleoside analogue,…”
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Inhibition of viral RNA polymerases by nucleoside and nucleotide analogs: therapeutic applications against positive-strand RNA viruses beyond hepatitis C virus by Deval, Jerome, Symons, Julian A, Beigelman, Leo

“…[Display omitted] •New therapies for infections caused by positive-strand RNA viruses are needed.•Novel nucleoside and nucleotide analogs that inhibit HCV have…”
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ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model by Vandyck, Koen, Abdelnabi, Rana, Gupta, Kusum, Jochmans, Dirk, Jekle, Andreas, Deval, Jerome, Misner, Dinah, Bardiot, Dorothée, Foo, Caroline S., Liu, Cheng, Ren, Suping, Beigelman, Leonid, Blatt, Lawrence M., Boland, Sandro, Vangeel, Laura, Dejonghe, Steven, Chaltin, Patrick, Marchand, Arnaud, Serebryany, Vladimir, Stoycheva, Antitsa, Chanda, Sushmita, Symons, Julian A., Raboisson, Pierre, Neyts, Johan

“…There is an urgent need for antivirals targeting the SARS-CoV-2 virus to fight the current COVID-19 pandemic. The SARS-CoV-2 main protease (3CLpro) represents…”
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Class A capsid assembly modulator RG7907 clears HBV-infected hepatocytes through core-dependent hepatocyte death and proliferation by Kum, Dieudonné Buh, Vanrusselt, Hannah, Acosta Sanchez, Abel, Taverniti, Valerio, Verrier, Eloi R, Baumert, Thomas F, Liu, Cheng, Deval, Jerome, Corthout, Nikky, Munck, Sebastian, Beigelman, Leonid, Blatt, Lawrence M, Symons, Julian A, Raboisson, Pierre, Jekle, Andreas, Vendeville, Sandrine, Debing, Yannick

“…Effective therapies leading to a functional cure for chronic hepatitis B are still lacking. Class A capsid assembly modulators (CAM-As) are an attractive…”
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Dual inhibition of SARS-CoV-2 and human rhinovirus with protease inhibitors in clinical development by Liu, Cheng, Boland, Sandro, Scholle, Michael D., Bardiot, Dorothee, Marchand, Arnaud, Chaltin, Patrick, Blatt, Lawrence M., Beigelman, Leonid, Symons, Julian A., Raboisson, Pierre, Gurard-Levin, Zachary A., Vandyck, Koen, Deval, Jerome

“…The 3-chymotrypsin-like cysteine protease (3CLpro) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is considered a major target for the…”
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