Search Results - "Symons, Jori"

Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch tolerance by Fareh, Mohamed, Zhao, Wei, Hu, Wenxin, Casan, Joshua M. L., Kumar, Amit, Symons, Jori, Zerbato, Jennifer M., Fong, Danielle, Voskoboinik, Ilia, Ekert, Paul G., Rudraraju, Rajeev, Purcell, Damian F. J., Lewin, Sharon R., Trapani, Joseph A.

“…The recent dramatic appearance of variants of concern of SARS-coronavirus-2 (SARS-CoV-2) highlights the need for innovative approaches that simultaneously…”
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HIV integration sites in latently infected cell lines: evidence of ongoing replication by Symons, Jori, Chopra, Abha, Malatinkova, Eva, De Spiegelaere, Ward, Leary, Shay, Cooper, Don, Abana, Chike O, Rhodes, Ajantha, Rezaei, Simin D, Vandekerckhove, Linos, Mallal, Simon, Lewin, Sharon R, Cameron, Paul U

“…Assessing the location and frequency of HIV integration sites in latently infected cells can potentially inform our understanding of how HIV persists during…”
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Relationship between CD4 T cell turnover, cellular differentiation and HIV persistence during ART by Bacchus-Souffan, Charline, Fitch, Mark, Symons, Jori, Abdel-Mohsen, Mohamed, Reeves, Daniel B, Hoh, Rebecca, Stone, Mars, Hiatt, Joseph, Kim, Peggy, Chopra, Abha, Ahn, Haelee, York, Vanessa A, Cameron, Daniel L, Hecht, Frederick M, Martin, Jeffrey N, Yukl, Steven A, Mallal, Simon, Cameron, Paul U, Deeks, Steven G, Schiffer, Joshua T, Lewin, Sharon R, Hellerstein, Marc K, McCune, Joseph M, Hunt, Peter W

“…The precise role of CD4 T cell turnover in maintaining HIV persistence during antiretroviral therapy (ART) has not yet been well characterized. In resting CD4…”
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Maraviroc Intensification of cART in Patients with Suboptimal Immunological Recovery: A 48-Week, Placebo-Controlled Randomized Trial by van Lelyveld, Steven F L, Drylewicz, Julia, Krikke, Maaike, Veel, Ellen M, Otto, Sigrid A, Richter, Clemens, Soetekouw, Robin, Prins, Jan M, Brinkman, Kees, Mulder, Jan Willem, Kroon, Frank, Middel, Ananja, Symons, Jori, Wensing, Annemarie M J, Nijhuis, Monique, Borghans, José A M, Tesselaar, Kiki, Hoepelman, Andy I M

“…The immunomodulatory effects of the CCR5-antagonist maraviroc might be beneficial in patients with a suboptimal immunological response, but results of…”
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HIV population genotypic tropism testing and its clinical significance by Obermeier, Martin, Symons, Jori, Wensing, Annemarie M.J

“…PURPOSE OF REVIEWHIV co-receptor tropism testing is recommended before therapy when the C-C chemokine receptor type 5 antagonist maraviroc is initiated. This…”
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Erratum to: HIV integration sites in latently infected cell lines: evidence of ongoing replication by Symons, Jori, Chopra, Abha, Malatinkova, Eva, De Spiegelaere, Ward, Leary, Shay, Cooper, Don, Abana, Chike O, Rhodes, Ajantha, Rezaei, Simin D, Vandekerckhove, Linos, Mallal, Simon, Lewin, Sharon R, Cameron, Paul U

“…In the original publication [1] the spelling of one author name was incorrect. The correct version: Eva Malatinkova…”
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HIV-1 Reverse Transcriptase Connection Domain Mutations: Dynamics of Emergence and Implications for Success of Combination Antiretroviral Therapy by von Wyl, Viktor, Ehteshami, Maryam, Demeter, Lisa M., Bürgisser, Philippe, Nijhuis, Monique, Symons, Jori, Yerly, Sabine, Böni, Jürg, Klimkait, Thomas, Schuurman, Rob, Ledergerber, Bruno, Götte, Matthias, Günthard, Huldrych F.

“…Background. Factors promoting the emergence of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) connection domain mutations and their…”
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Improved single-chain transactivators of the Tet-On gene expression system by Zhou, Xue, Symons, Jori, Hoppes, Rieuwert, Krueger, Christel, Berens, Christian, Hillen, Wolfgang, Berkhout, Ben, Das, Atze T

“…The Tet-Off (tTA) and Tet-On (rtTA) regulatory systems are widely applied to control gene expression in eukaryotes. Both systems are based on the Tet repressor…”
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In Vivo T Cell-Targeting Nanoparticle Drug Delivery Systems: Considerations for Rational Design by Cevaal, Paula M, Ali, Abdalla, Czuba-Wojnilowicz, Ewa, Symons, Jori, Lewin, Sharon R, Cortez-Jugo, Christina, Caruso, Frank

“…T cells play an important role in immunity and repair and are implicated in diseases, including blood cancers, viral infections, and inflammation, making them…”
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HIV integration sites and implications for maintenance of the reservoir by Symons, Jori, Cameron, Paul U, Lewin, Sharon R

“…PURPOSE OF REVIEWTo provide an overview of recent research of how HIV integration relates to productive and latent infection and implications for cure…”
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Shock and kill within the CNS: A promising HIV eradication approach? by Nühn, Marieke M., Gumbs, Stephanie B. H., Buchholtz, Ninée V. E. J., Jannink, Lisanne M., Gharu, Lavina, Witte, Lot D., Wensing, Annemarie M. J., Lewin, Sharon R., Nijhuis, Monique, Symons, Jori

“…The most studied HIV eradication approach is the “shock and kill” strategy, which aims to reactivate the latent reservoir by latency reversing agents (LRAs)…”
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CXCR4-Using HIV Strains Predominate in Naive and Central Memory CD4 + T Cells in People Living with HIV on Antiretroviral Therapy: Implications for How Latency Is Established and Maintained by Roche, Michael, Tumpach, Carolin, Symons, Jori, Gartner, Matthew, Anderson, Jenny L, Khoury, Gabriela, Cashin, Kieran, Cameron, Paul U, Churchill, Melissa J, Deeks, Steven G, Gorry, Paul R, Lewin, Sharon R

“…HIV can persist in people living with HIV (PLWH) on antiretroviral therapy (ART) in multiple CD4 T cell subsets, including naive cells, central memory (CM)…”
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Persistence of envelopes in different CD4 + T-cell subsets in antiretroviral therapy-suppressed people with HIV by Gartner, Matthew J., Tumpach, Carolin, Dantanarayana, Ashanti, Stern, Jared, Zerbato, Jennifer M., Chang, J. Judy, Angelovich, Thomas A., Anderson, Jenny L., Symons, Jori, Deeks, Steve G., Flynn, Jacqueline K., Lewin, Sharon R., Churchill, Melissa J., Gorry, Paul R., Roche, Michael

“…Despite suppressive antiretroviral therapy (ART), HIV can persist in a diverse range of CD4+ T-cell subsets. Through longitudinal env sampling from people with…”
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Acoustofection: High-Frequency Vibrational Membrane Permeabilization for Intracellular siRNA Delivery into Nonadherent Cells by Ramesan, Shwathy, Rezk, Amgad R, Cevaal, Paula M, Cortez-Jugo, Christina, Symons, Jori, Yeo, Leslie Y

“…The internalization of therapeutic molecules into cellsa critical step in enabling a suite of autologous ex vivo gene and cell therapiesis highly regulated…”
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Nanoscale probing and imaging of HIV-1 RNA in cells with a chimeric LNA-DNA sensor by Amodio, Alessia, Cassani, Marco, Mummolo, Liviana, Cortez-Jugo, Christina, Bhangu, Sukhvir Kaur, Symons, Jori, Ahlenstiel, Chantelle L, Forte, Giancarlo, Ricci, Francesco, Kelleher, Anthony D, Lewin, Sharon R, Cavalieri, Francesca, Caruso, Frank

“…Real-time detection and nanoscale imaging of human immunodeficiency virus type 1 ribonucleic acid (HIV-1 RNA) in latently infected cells that persist in people…”
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Neurotoxicity with high dose disulfiram and vorinostat used for HIV latency reversal by Mcmahon, James H., Evans, Vanessa A., Lau, Jillian S.Y., Symons, Jori, Zerbato, Jennifer M., Chang, Judy, Solomon, Ajantha, Tennakoon, Surekha, Dantanarayana, Ashanti, Hagenauer, Michelle, Lee, Sulggi, Palmer, Sarah, Fisher, Katie, Bumpus, Namandje, Heck, Carley J.S., Burger, David, Wu, Guoxin, Zuck, Paul, Howell, Bonnie J., Zetterberg, Henrik H., Blennow, Kaj, Gisslen, Magnus, Rasmussen, Thomas A., Lewin, Sharon R.

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Virological and immunological correlates of HIV posttreatment control after temporal antiretroviral therapy during acute HIV infection by van Paassen, Pien M, van Pul, Lisa, van der Straten, Karlijn, Buchholtz, Ninée V J E, Grobben, Marloes, van Nuenen, Ad C, van Dort, Karel A, Boeser-Nunnink, Brigitte D, van den Essenburg, Mo D, Burger, Judith A, van Luin, Matthijs, Jurriaans, Suzanne, Sanders, Rogier W, Swelsen, Wendy T, Symons, Jori, Klouwens, Michelle J, Nijhuis, Monique, van Gils, Marit J, Prins, Jan M, de Bree, Godelieve J, Kootstra, Neeltje A

“…People with HIV rarely control viral replication after cessation of antiretroviral therapy (ART). We present a person with HIV with extraordinary posttreatment…”
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Dependence on the CCR5 Coreceptor for Viral Replication Explains the Lack of Rebound of CXCR4-Predicted HIV Variants in the Berlin Patient by Symons, Jori, Vandekerckhove, Linos, Hütter, Gero, Wensing, Annemarie M. J., van Ham, Petra M., Deeks, Steven G., Nijhuis, Monique

“…The "Berlin patient" is the first patient cured of HIV-1 infection after allogeneic transplantation with nonfunctional CCR5 coreceptor stem cells. We…”
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Neurotoxicity with high-dose disulfiram and vorinostat used for HIV latency reversal by McMahon, James H., Evans, Vanessa A., Lau, Jillian S.Y., Symons, Jori, Zerbato, Jennifer M., Chang, Judy, Solomon, Ajantha, Tennakoon, Surekha, Dantanarayana, Ashanti, Hagenauer, Michelle, Lee, Sulggi, Palmer, Sarah, Fisher, Katie, Bumpus, Namandje, Heck, Carley J.S., Burger, David, Wu, Guoxin, Zuck, Paul, Howell, Bonnie J., Zetterberg, Henrik H., Blennow, Kaj, Gisslen, Magnus, Rasmussen, Thomas A., Lewin, Sharon R.

“…The aim of this study was to examine whether administering both vorinostat and disulfiram to people with HIV (PWH) on antiretroviral therapy (ART) is well…”
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De novo design of CRISPR-Cas13b enables efficient silencing of SARS-CoV-2 variants and tumour pathogenic RNAs with near single-base precision by Hu, Wenxin, Zhao, Wei, Kumar, Amit, Singh, Gurjeet Jagjeet, Qi, Shijiao, Casan, Josh, Shembery, Carolyn, Fong, Danielle, Zerbato, Jennifer M., Symons, Jori, Rudraraju, Rajeev, Purcell, Damian, Haber, Michelle, Voskoboinik, Ilia, Ekert, Paul G., Lewin, Sharon, Trapani, Joseph, Fareh, Mohamed

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