Search Results - "Symington, Lorraine S."

Mechanism and regulation of DNA end resection in eukaryotes by Symington, Lorraine S

“…The repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) is initiated by nucleolytic degradation of the 5'-terminated strands in a…”
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Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway? by Sfeir, Agnel, Symington, Lorraine S.

“…DNA double-strand breaks (DSBs) disrupt the continuity of chromosomes and their repair by error-free mechanisms is essential to preserve genome integrity…”
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RPA Coordinates DNA End Resection and Prevents Formation of DNA Hairpins by Chen, Huan, Lisby, Michael, Symington, Lorraine S.

“…Replication protein A (RPA) is an essential eukaryotic single-stranded DNA binding protein with a central role in DNA metabolism. RPA directly participates in…”
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Double-Strand Break End Resection and Repair Pathway Choice by Symington, Lorraine S, Gautier, Jean

“…DNA double-strand breaks (DSBs) are cytotoxic lesions that can result in mutagenic events or cell death if left unrepaired or repaired inappropriately. Cells…”
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Mechanisms and regulation of mitotic recombination in Saccharomyces cerevisiae by Symington, Lorraine S, Rothstein, Rodney, Lisby, Michael

“…Homology-dependent exchange of genetic information between DNA molecules has a profound impact on the maintenance of genome integrity by facilitating…”
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Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing by Mimitou, Eleni P, Symington, Lorraine S

“…DNA ends exposed after introduction of double-strand breaks (DSBs) undergo 5′–3′ nucleolytic degradation to generate single-stranded DNA, the substrate for…”
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Break-induced replication occurs by conservative DNA synthesis by Donnianni, Roberto A., Symington, Lorraine S.

“…Break-induced replication (BIR) refers to recombination-dependent DNA synthesis initiated from one end of a DNA double-strand break and can extend for more…”
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Mechanism for inverted-repeat recombination induced by a replication fork barrier by Marie, Léa, Symington, Lorraine S.

“…Replication stress and abundant repetitive sequences have emerged as primary conditions underlying genomic instability in eukaryotes. To gain insight into the…”
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Xrs2 Dependent and Independent Functions of the Mre11-Rad50 Complex by Oh, Julyun, Al-Zain, Amr, Cannavo, Elda, Cejka, Petr, Symington, Lorraine S.

“…The Mre11-Rad50-Xrs2/Nbs1 (MRX/N) complex orchestrates the cellular response to DSBs through its structural, enzymatic, and signaling roles. Xrs2/Nbs1 is…”
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Role of the Mre11 Complex in Preserving Genome Integrity by Oh, Julyun, Symington, Lorraine S

“…DNA double-strand breaks (DSBs) are hazardous lesions that threaten genome integrity and cell survival. The DNA damage response (DDR) safeguards the genome by…”
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Mph1 and Mus81-Mms4 Prevent Aberrant Processing of Mitotic Recombination Intermediates by Mazón, Gerard, Symington, Lorraine S.

“…Homology-dependent repair of double-strand breaks (DSBs) from nonsister templates has the potential to generate loss of heterozygosity or genome…”
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RPA antagonizes microhomology-mediated repair of DNA double-strand breaks by Deng, Sarah K, Gibb, Bryan, de Almeida, Mariana Justino, Greene, Eric C, Symington, Lorraine S

“…Resection of DNA double strand–break ends generates single strands that can spontaneously anneal to undergo mutagenic microhomology-mediated end joining…”
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Role of RAD52 Epistasis Group Genes in Homologous Recombination and Double-Strand Break Repair by SYMINGTON, Lorraine S

“…Article Usage Stats Services MMBR Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Nucleases and helicases take center stage in homologous recombination by Mimitou, Eleni P., Symington, Lorraine S.

“…Homologous recombination (HR)-mediated DNA double-strand break repair maintains genome integrity. Although long-studied, an understanding of two essential…”
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Template switching during break-induced replication by SMITH, Catherine E, LLORENTE, Bertrand, SYMINGTON, Lorraine S

“…DNA double-strand breaks (DSBs) are potentially lethal lesions that arise spontaneously during normal cellular metabolism, as a consequence of environmental…”
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Double-strand breaks induce inverted duplication chromosome rearrangements by a DNA polymerase δ-dependent mechanism by Al-Zain, Amr M., Nester, Mattie R., Ahmed, Iffat, Symington, Lorraine S.

“…Inverted duplications, also known as foldback inversions, are commonly observed in cancers and are the major class of chromosome rearrangement recovered from…”
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Break-induced replication: What is it and what is it for? by Llorente, Bertrand, Smith, Catherine E., Symington, Lorraine S.

“…Homologous recombination (HR) is considered to be an error-free mechanism for the repair of DNA double-strand breaks (DSBs). Indeed, most DSB repair events…”
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Recombination proteins in yeast by Krogh, Berit Olsen, Symington, Lorraine S

“…The process of homologous recombination promotes error-free repair of double-strand breaks and is essential for meiosis. Central to the process of homologous…”
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Mus81 and Yen1 Promote Reciprocal Exchange during Mitotic Recombination to Maintain Genome Integrity in Budding Yeast by Ho, Chu Kwen, Mazón, Gerard, Lam, Alicia F., Symington, Lorraine S.

“…Holliday junction (HJ) resolution is required for segregation of chromosomes and for formation of crossovers during homologous recombination. The identity of…”
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Mre11-Sae2 and RPA Collaborate to Prevent Palindromic Gene Amplification by Deng, Sarah K., Yin, Yi, Petes, Thomas D., Symington, Lorraine S.

“…Foldback priming at DNA double-stranded breaks is one mechanism proposed to initiate palindromic gene amplification, a common feature of cancer cells. Here, we…”
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