Search Results - "Symes, James F"

Direct intramuscular gene transfer of naked DNA encoding vascular endothelial growth factor augments collateral development and tissue perfusion by TSURUMI, Y, TAKESHITA, S, CHEN, D, KEARNEY, M, ROSSOW, S. T, PASSERI, J, HOROWITZ, J. R, SYMES, J. F, ISNER, J. M

“…Striated muscle has been shown to be capable of taking up and expressing foreign genes transferred in the form of naked plasmid DNA, although typically with a…”
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Local delivery of vascular endothelial growth factor accelerates reendothelialization and attenuates intimal hyperplasia in balloon-injured rat carotid artery by ASAHARA, T, BAUTERS, C, PASTORE, C, KEARNEY, M, ROSSOW, S, BUNTING, S, FERRARA, N, SYMES, J. F, ISNER, J. M

“…Most strategies designed to reduce restenosis by the use of pharmacological or biological reagents involve direct inhibition of vascular smooth muscle cell…”
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Vascular Endothelial Growth Factor Attenuates Myocardial Ischemia-Reperfusion Injury by Luo, Zhengyu, Diaco, Maurizio, Murohara, Toyoaki, Ferrara, Napoleone, Isner, Jeffrey M, Symes, James F

“…Background. Hypoxic endothelial cell activation plays a key role in the myocardial dysfunction resulting from ischemia-reperfusion injury. Recent evidence…”
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Recovery of disturbed endothelium-dependent flow in the collateral-perfused rabbit ischemic hindlimb after administration of vascular endothelial growth factor by BAUTERS, C, ASAHARA, T, ZHENG, L. P, TAKESHITA, S, BUNTING, S, FERRARA, N, SYMES, J. F, ISNER, J. M

“…Disturbed endothelium-dependent blood flow has been shown to be a feature of native collateral vessels. Recent studies have shown that recombinant angiogenic…”
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In vivo magnetic resonance imaging and surgical histopathology of intracardiac masses: distinct features of subacute thrombi by Paydarfar, D, Krieger, D, Dib, N, Blair, R H, Pastore, J O, Stetz, Jr, J J, Symes, J F

“…We evaluated intracardiac masses in vivo, in situ and histologically to determine tissue properties revealed by magnetic resonance (MR) imaging. In 15…”
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Gene therapy for myocardial angiogenesis: Initial clinical results with direct myocardial injection of phVEGF165 as sole therapy for myocardial ischemia by LOSORDO, D. W, VALE, P. R, SYMES, J. F, DUNNINGTON, C. H, ESAKOF, D. D, MAYSKY, M, ASHARE, A. B, LATHI, K, ISNER, J. M

“…We initiated a phase 1 clinical study to determine the safety and bioactivity of direct myocardial gene transfer of vascular endothelial growth factor (VEGF)…”
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Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb by Isner, J M, Pieczek, A, Schainfeld, R, Blair, R, Haley, L, Asahara, T, Rosenfield, K, Razvi, S, Walsh, K, Symes, J F

“…Preclinical findings suggest that intra-arterial gene transfer of a plasmid which encodes for vascular endothelial growth factor (VEGF) can improve blood…”
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VEGF gene transfer mobilizes endothelial progenitor cells in patients with inoperable coronary disease by Kalka, Christoph, Tehrani, Hassan, Laudenberg, Bernd, Vale, Peter R, Isner, Jeffrey M, Asahara, Takayuki, Symes, James F

“…Background. Direct transfection of ischemic myocardium with naked plasmid DNA encoding for vascular endothelial growth factor-165 (VEGF 165) has been shown to…”
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Randomized, single-blind, placebo-controlled pilot study of catheter-based myocardial gene transfer for therapeutic angiogenesis using left ventricular electromechanical mapping in patients with chronic myocardial ischemia by VALE, Peter R, LOSORDO, Douglas W, MILLIKEN, Charles E, MCDONALD, Maria C, GRAVELIN, Laura M, CURRY, Cynthia M, ESAKOF, Darryl D, MAYSKY, Michael, SYMES, James F, ISNER, Jeffrey M

“…Catheter-based myocardial gene transfer (GTx) has not been previously tested in human subjects. Accordingly, we performed a pilot study to investigate the…”
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Gene therapy with vascular endothelial growth factor for inoperable coronary artery disease by Symes, James F, Losordo, Douglas W, Vale, Peter R, Lathi, Kishor G, Esakof, Darryl D, Mayskiy, Michael, Isner, Jeffrey M

“…Background. Patients presenting with medically intractable angina who have undergone previous coronary bypass (CABG) and/or percutaneous revascularization…”
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Treatment of thromboangiitis obliterans (Buerger's disease) by intramuscular gene transfer of vascular endothelial growth factor: Preliminary clinical results by Isner, Jeffrey M., Baumgartner, Iris, Rauh, Guenter, Schainfeld, Robert, Blair, Richard, Manor, Orit, Razvi, Syed, Symes, James F.

“…Purpose: Thromboangiitis obliterans (TAO), or Buerger's disease, a distinct form of vascular occlusive disease that afflicts the peripheral arteries of young…”
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Surgical Treatment of an Amniotic Fluid Embolism With Cardiopulmonary Collapse by Lee, Peter H.U., Shulman, Mark S., Vellayappan, Usha, Symes, James F., Olenchock, Stephen A.

“…Amniotic fluid embolism is a rare but devastating condition associated with a very high rate of morbidity and mortality. The treatment has traditionally been…”
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Assessment of Risks Associated With Cardiovascular Gene Therapy in Human Subjects by Isner, Jeffrey M, Vale, Peter R, Symes, James F, Losordo, Douglas W

“…Clinical trials of cardiovascular gene therapy, whether using viral (53%) or nonviral (47%) vectors, have thus far disclosed no evidence indicative of…”
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Synergistic effect of vascular endothelial growth factor and basic fibroblast growth factor on angiogenesis in vivo by Asahara, T, Bauters, C, Zheng, L P, Takeshita, S, Bunting, S, Ferrara, N, Symes, J F, Isner, J M

“…Recent studies have suggested that vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) may have synergistic effects on the…”
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Retraction notice to “Surgical Treatment of an Amniotic Fluid Embolism With Cardiopulmonary Collapse” [Ann Thorac Surg 90 (2010) 1694–1696] by Lee, Peter H.U., MD, MPH, Shulman, Mark S., MD, Vellayappan, Usha, MD, Symes, James F., MD, Olenchock, Stephen A., DO

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Accelerated restitution of endothelial integrity and endothelium-dependent function after phVEGF165 gene transfer by ASAHARA, T, CHEN, D, TSURUMI, Y, KEARNEY, M, ROSSOW, S, PASSERI, J, SYMES, J. F, ISNER, J. M

“…Delinquent reendothelialization (rET) has been shown to have a permissive, if not facilitatory, impact on smooth muscle cell proliferation. This inverse…”
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Vascular Endothelial Growth Factor/Vascular Permeability Factor Produces Nitric Oxide-Dependent Hypotension: Evidence for a Maintenance Role in Quiescent Adult Endothelium by Horowitz, Jeffrey R, Rivard, Alain, van der Zee, Rien, Hariawala, Mukesh, Sheriff, Don D, Esakof, Darryl D, Chaudhry, G. Muqtada, Symes, James F, Isner, Jeffrey M

“…In vitro studies suggest that vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) may stimulate release of nitric oxide (NO) from…”
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Cardiac computed tomography in the evaluation of an intra-pericardial mediastinal mass by Tanawuttiwat, Tanyanan, Brice, Tania, Symes, James F, Khramov, Iliya, Schob, Alan H

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RETRACTED: Surgical Treatment of an Amniotic Fluid Embolism With Cardiopulmonary Collapse by Lee, Peter H.U., MD, MPH, Shulman, Mark S., MD, Vellayappan, Usha, MD, Symes, James F., MD, Olenchock, Stephen A., DO

“…This article has been retracted: please see Elsevier Policy on Article Withdrawal ( http://www.elsevier.com/locate/withdrawalpolicy ). This article has been…”
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Hypercholesterolemia attenuates angiogenesis but does not preclude augmentation by angiogenic cytokines by VAN BELLE, E, RIVARD, A, CHEN, D, SILVER, M, BUNTING, S, FERRARA, N, SYMES, J. F, BAUTERS, C, ISNER, J. M

“…The impact of hyperlipidemia on collateral vessel development in vivo remains enigmatic. We sought to determine the anatomic extent and functional capacity of…”
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