Search Results - "Sylvestre, P"
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An expanded palette of fluorogenic HaloTag probes with enhanced contrast for targeted cellular imaging
Published in Organic & biomolecular chemistry (04-05-2022)“…We report the development of HaloTag fluorogens based on dipolar flexible molecular rotor structures. By modulating the electron donating and withdrawing…”
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Fluorogenic Protein Probes with Red and Near‐Infrared Emission for Genetically Targeted Imaging
Published in Chemistry : a European journal (11-11-2020)“…Fluorogenic probes are important tools to image proteins with high contrast and no wash protocols. In this work, we rationally designed and synthesized a small…”
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Design of Bright Chemogenetic Reporters Based on the Combined Engineering of Fluorogenic Molecular Rotors and of the HaloTag Protein
Published in Chemistry : a European journal (06-06-2024)“…The combination of fluorogenic probes (fluorogens) and self‐labeling protein tags represent a promising tool for imaging biological processes with high…”
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A Dynamic Thermodynamic Resolution Strategy for the Stereocontrolled Synthesis of Streptonigrin
Published in Angewandte Chemie International Edition (26-01-2023)“…We report that axially chiral biaryl boronic esters can be generated with control of atroposelectivity by a Binol‐mediated dynamic thermodynamic resolution…”
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Diagnostic validity and triage concordance of a physiotherapist compared to physicians' diagnoses for common knee disorders
Published in BMC musculoskeletal disorders (14-11-2017)“…Emergence of more autonomous roles for physiotherapists warrants more evidence regarding their diagnostic capabilities. Therefore, we aimed to evaluate…”
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Nicotine dependence and sleep quality in young adults
Published in Addictive behaviors (01-02-2017)“…Abstract Introduction More cigarette smokers report poor sleep quality than non-smokers, but the association between nicotine dependence (ND) and sleep quality…”
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7
Development of a Mild and Versatile Directed Cycloaddition Approach to Pyridines
Published in Chemistry : a European journal (26-09-2014)“…The aza‐Diels–Alder cycloaddition of 1,2,4‐triazines with alkynes offers a rapid and convenient method for the synthesis of highly substituted pyridines, but…”
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Synthetic Sphingolipids with 1,2-Pyridazine Appendages Improve Antiproliferative Activity in Human Cancer Cell Lines
Published in ACS medicinal chemistry letters (14-05-2020)“…A synthetic sphingolipid related to a ring-constrained hydroxymethyl pyrrolidine analog of FTY720 that was known to starve cancer cells to death was chemically…”
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10
Extraction and quantification of amino acids in human stratum corneum in vivo
Published in British journal of dermatology (1951) (01-09-2010)“…Summary Background Amino acid (AA) levels in stratum corneum (SC) are potential biomarkers of skin health while their systemic levels may be used to diagnose…”
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A Modular Class of Fluorescent Difluoroboranes: Synthesis, Structure, Optical Properties, Theoretical Calculations and Applications for Biological Imaging
Published in Chemistry : a European journal (22-08-2016)“…Ten borylated bipyridines (BOBIPYs) have been synthesized and selected structural modifications have been made that allow useful structure–optical property…”
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Anatomic and Angiographic Analyses of Ophthalmic Artery Collaterals in Moyamoya Disease
Published in American journal of neuroradiology : AJNR (01-06-2018)“…Moyamoya disease is a progressive neurovascular pathology defined by steno-occlusive disease of the distal internal carotid artery and associated with the…”
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A proposed grading system to evaluate the endovascular curability of deep-seated arteriovenous malformations
Published in Journal of the neurological sciences (15-06-2017)“…Abstract Background Aggressive treatment of deep-seated AVMs is paramount because of their high tendency to bleed (or to re-bleed). In the literature…”
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Synthesis, characterisation and reactions of phosphine-substituted alkynylboronates and alkynyltrifluoroborate salts
Published in Molecules (Basel, Switzerland) (18-12-2014)“…The synthesis and structural characterisation of phosphine-substituted alkynylboronates is reported. A P(III)-centred alkynylboronate (2) was prepared that…”
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A Dynamic Thermodynamic Resolution Strategy for the Stereocontrolled Synthesis of Streptonigrin
Published in Angewandte Chemie (26-01-2023)“…We report that axially chiral biaryl boronic esters can be generated with control of atroposelectivity by a Binol‐mediated dynamic thermodynamic resolution…”
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Patterns of Injury in Mycophenolate Mofetil–Related Colitis
Published in Transplantation proceedings (01-11-2010)“…Abstract Mycophenolate mofetil (MMF) was introduced as a new immune-suppression drug in the mid-1990s. It is widely utilized in solid-organ transplantation…”
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Recurrence of primary biliary cirrhosis after liver transplantation: Histologic estimate of incidence and natural history
Published in Liver transplantation (01-10-2003)“…The goals of this study were to determine the rate of recurrent primary biliary cirrhosis (PBC) after orthotopic liver transplantation (OLT) based on strict…”
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Immediate and past cumulative effects of oral glucocorticoids on the risk of acute myocardial infarction in rheumatoid arthritis: a population-based study
Published in Rheumatology (Oxford, England) (01-01-2013)“…To determine the effect of glucocorticoids (GCs) on acute myocardial infarction (MI) risk in patients with RA. Using administrative health data, we conducted a…”
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Interferon gamma-1b for the treatment of fibrosis in chronic hepatitis C infection
Published in Journal of viral hepatitis (01-05-2006)“…Given that the complications of hepatitis C are due to fibrosis, we hypothesized that the antifibrotic effects of interferon gamma on stellate cells would lead…”
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Iontophoresis of dexamethasone phosphate: Competition with chloride ions
Published in Journal of controlled release (06-10-2008)“…The objective was to study the competition of chloride released from a Ag/AgCl cathode on the iontophoretic delivery of dexamethasone phosphate (Dex-Phos)…”
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