Search Results - "Sylvestre, J"
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Notch1-induced mammary tumor development is cyclin D1-dependent and correlates with expansion of pre-malignant multipotent duct-limited progenitors
Published in Oncogene (12-08-2010)“…Members of the Notch family are involved in the development of breast cancer in animal models and in humans. In young transgenic mice, expressing intracellular…”
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An expanded palette of fluorogenic HaloTag probes with enhanced contrast for targeted cellular imaging
Published in Organic & biomolecular chemistry (04-05-2022)“…We report the development of HaloTag fluorogens based on dipolar flexible molecular rotor structures. By modulating the electron donating and withdrawing…”
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Fluorogenic Protein Probes with Red and Near‐Infrared Emission for Genetically Targeted Imaging
Published in Chemistry : a European journal (11-11-2020)“…Fluorogenic probes are important tools to image proteins with high contrast and no wash protocols. In this work, we rationally designed and synthesized a small…”
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Design of Bright Chemogenetic Reporters Based on the Combined Engineering of Fluorogenic Molecular Rotors and of the HaloTag Protein
Published in Chemistry : a European journal (06-06-2024)“…The combination of fluorogenic probes (fluorogens) and self‐labeling protein tags represent a promising tool for imaging biological processes with high…”
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Extraction and quantification of amino acids in human stratum corneum in vivo
Published in British journal of dermatology (1951) (01-09-2010)“…Summary Background Amino acid (AA) levels in stratum corneum (SC) are potential biomarkers of skin health while their systemic levels may be used to diagnose…”
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A Dynamic Thermodynamic Resolution Strategy for the Stereocontrolled Synthesis of Streptonigrin
Published in Angewandte Chemie International Edition (26-01-2023)“…We report that axially chiral biaryl boronic esters can be generated with control of atroposelectivity by a Binol‐mediated dynamic thermodynamic resolution…”
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Impaired cardiac glycolysis and glycogen depletion are linked to poor myocardial outcomes in juvenile male swine with metabolic syndrome and ischemia
Published in Physiological reports (01-08-2023)“…Obesity continues to rise in the juveniles and obese children are more likely to develop metabolic syndrome (MetS) and related cardiovascular disease…”
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Development of a Mild and Versatile Directed Cycloaddition Approach to Pyridines
Published in Chemistry : a European journal (26-09-2014)“…The aza‐Diels–Alder cycloaddition of 1,2,4‐triazines with alkynes offers a rapid and convenient method for the synthesis of highly substituted pyridines, but…”
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The role of the 3' untranslated region in mRNA sorting to the vicinity of mitochondria is conserved from yeast to human cells
Published in Molecular biology of the cell (01-09-2003)“…We recently demonstrated, using yeast DNA microarrays, that mRNAs of polysomes that coisolate with mitochondria code for a subset of mitochondrial proteins…”
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Synthetic Sphingolipids with 1,2-Pyridazine Appendages Improve Antiproliferative Activity in Human Cancer Cell Lines
Published in ACS medicinal chemistry letters (14-05-2020)“…A synthetic sphingolipid related to a ring-constrained hydroxymethyl pyrrolidine analog of FTY720 that was known to starve cancer cells to death was chemically…”
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Iontophoresis of dexamethasone phosphate: Competition with chloride ions
Published in Journal of controlled release (06-10-2008)“…The objective was to study the competition of chloride released from a Ag/AgCl cathode on the iontophoretic delivery of dexamethasone phosphate (Dex-Phos)…”
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Synthesis, characterisation and reactions of phosphine-substituted alkynylboronates and alkynyltrifluoroborate salts
Published in Molecules (Basel, Switzerland) (18-12-2014)“…The synthesis and structural characterisation of phosphine-substituted alkynylboronates is reported. A P(III)-centred alkynylboronate (2) was prepared that…”
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Effects of macronutrient content and energy density of snacks consumed in a satiety state on the onset of the next meal
Published in Appetite (01-04-2000)“…We examined the effects of nutrient composition of a 1MJ afternoon snack, consumed in a satiety state, on the spontaneous onset of the next meal in 11 young…”
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Modeling the influence of the porosity of laser-ablated silicon films on their photoluminescence properties
Published in Applied surface science (28-02-2008)“…Nanostructured porous Si-based films produced by pulsed laser ablation (PLA) from a silicon target in residual helium gas can exhibit both size-dependent…”
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A Modular Class of Fluorescent Difluoroboranes: Synthesis, Structure, Optical Properties, Theoretical Calculations and Applications for Biological Imaging
Published in Chemistry : a European journal (22-08-2016)“…Ten borylated bipyridines (BOBIPYs) have been synthesized and selected structural modifications have been made that allow useful structure–optical property…”
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An endocrine and metabolic definition of the intermeal interval in humans: Evidence for a role of leptin on the prandial pattern through fatty acid disposal
Published in The American journal of clinical nutrition (01-08-2000)“…It has been proposed that leptin provides a hormonal link between adipose stores and food intake. This study investigated the role of leptin in the prandial…”
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Outbreak of tuberculosis among substance users and homeless people in Greater Montréal, Canada, 2003-2016
Published in Canada communicable disease report (02-03-2017)“…In Canada, active tuberculosis (TB) is found mainly among migrants from endemic countries and Indigenous populations. However, cases of active tuberculosis in…”
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Preoxygenation by high-flow nasal cannula in a patient with difficult ventilation and intubation criteria
Published in Revue médicale de Liège (01-04-2021)“…The different protocols and algorithms for difficult intubation highlight the need for early detection of patients at risk of ventilation and difficult…”
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Identification of a 95-kDa WEE1-Like Tyrosine Kinase in HeLa Cells
Published in Proceedings of the National Academy of Sciences - PNAS (10-10-1995)“…Human WEE1 (WEE1Hu) was cloned on the basis of its ability to rescue wee1+mutants in fission yeast [Igarashi, M., Nagata, A., Jinno, S., Suto, K. \& Okayama,…”
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