Search Results - "Sylvester, Paul W."

GLUT2 regulation of p38 MAPK isoform protein expression and p38 phosphorylation in male versus female rat hypothalamic primary astrocyte Cultures by Pasula, Madhu Babu, Sylvester, Paul W., Briski, Karen P.

“…Recent studies documented regulation of hypothalamic astrocyte mitogen-activated protein kinase (MAPK) pathways, including p38, by the plasma membrane glucose…”
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Optimization of the tetrazolium dye (MTT) colorimetric assay for cellular growth and viability by Sylvester, Paul W

“…The MTT colorimetric assay is an established method of determining viable cell number in proliferation and cytotoxicity studies. This assay is based on the…”
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Singular versus combinatory glucose-sensitive signal control of metabolic sensor protein profiles in hypothalamic astrocyte cultures from each sex by Alhamyani, Abdulrahman, Napit, Prabhat R., Bheemanapally, Khaggeswar, Sylvester, Paul W., Briski, Karen P.

“…Brain metabolic-sensory targets for modulatory glucose-sensitive endocrine and neurochemical signals remain unidentified. A hypothalamic astrocyte primary…”
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Tocotrienols target PI3K/Akt signaling in anti-breast cancer therapy by Sylvester, Paul W, Ayoub, Nehad M

“…The PI3K/Akt signaling pathway mediates mitogen-dependent growth and survival in various types of cancer cells, and inhibition of this pathway results in tumor…”
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Targeting met mediated epithelial-mesenchymal transition in the treatment of breast cancer by Sylvester, Paul W

“…Mesenchymal epithelial transition factor receptor (Met) is a receptor tyrosine kinase that plays a critical role in promoting cancer cell malignant…”
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Glucose Transporter-2 Regulation of Male versus Female Hypothalamic Astrocyte MAPK Expression and Activation: Impact of Glucose by Pasula, MadhuBabu, Roy, Sagor C, Bheemanapally, Khaggeswar, Sylvester, Paul W, Briski, Karen P

“…The plasma membrane glucose transporter (GLUT)-2 is unique among GLUT family proteins in that it also functions as a glucose sensor. GLUT2 imposes…”
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Enhanced antiproliferative and apoptotic response to combined treatment of gamma-tocotrienol with erlotinib or gefitinib in mammary tumor cells by Bachawal, Sunitha V, Wali, Vikram B, Sylvester, Paul W

“…Aberrant ErbB receptor signaling is associated with various types of malignancies. gamma-Tocotrienol is a member of the vitamin E family of compounds that…”
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Synergistic Antiproliferative Effects of Combined γ-Tocotrienol and PPARγAntagonist Treatment Are Mediated through PPARγ-Independent Mechanisms in Breast Cancer Cells by Malaviya, Abhita, Sylvester, Paul W.

“…Previous findings showed that the anticancer effects of combined γ-tocotrienol and peroxisome proliferator activated receptor γ (PPARγ) antagonist treatment…”
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Norepinephrine Regulation of Adrenergic Receptor Expression, 5’ AMP-Activated Protein Kinase Activity, and Glycogen Metabolism and Mass in Male Versus Female Hypothalamic Primary Astrocyte Cultures by Ibrahim, Mostafa M. H., Bheemanapally, Khaggeswar, Sylvester, Paul W., Briski, Karen P.

“…Norepinephrine (NE) control of hypothalamic gluco-regulation involves astrocyte-derived energy fuel supply. In male rats, exogenous NE regulates astrocyte…”
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Potential role of tocotrienols in the treatment and prevention of breast cancer by Sylvester, Paul W., Akl, Mohamed R., Malaviya, Abhita, Parajuli, Parash, Ananthula, Suryatheja, Tiwari, Roshan V., Ayoub, Nehad M.

“…Vitamin E is a generic term that refers to a family of compounds that is further divided into two subgroups called tocopherols and tocotrienols. Although all…”
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Tocotrienol-induced caspase-8 activation is unrelated to death receptor apoptotic signaling in neoplastic mammary epithelial cells by Shah, Sumit, Sylvester, Paul W

“…Tocotrienols, a subclass in the vitamin E family of compounds, have been shown to induce apoptosis by activating caspase-8 and caspase-3 in neoplastic mammary…”
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A new mixed-backbone oligonucleotide against glucosylceramide synthase sensitizes multidrug-resistant tumors to apoptosis by Patwardhan, Gauri A, Zhang, Qian-Jin, Yin, Dongmei, Gupta, Vineet, Bao, Jianxiong, Senkal, Can E, Ogretmen, Besim, Cabot, Myles C, Shah, Girish V, Sylvester, Paul W, Jazwinski, S Michal, Liu, Yong-Yu

“…Enhanced ceramide glycosylation catalyzed by glucosylceramide synthase (GCS) limits therapeutic efficiencies of antineoplastic agents including doxorubicin in…”
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Tocotrienol combination therapy results in synergistic anticancer response by Sylvester, Paul W, Wali, Vikram B, Bachawal, Sunitha V, Shirode, Amit B, Ayoub, Nehad M, Akl, Mohamed R

“…Vitamin E represents a family of compounds that is divided into two subgroups called tocopherols and tocotrienols, which act as important antioxidants that…”
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Role of Caspase-8 Activation in Mediating Vitamin E-Induced Apoptosis in Murine Mammary Cancer Cells by Shah, Sumit, Gapor, Abdul, Sylvester, Paul W

“…The vitamin E family of compounds is divided into two subgroups, tocopherols and tocotrienols. However, tocotrienols display more potent apoptotic activity in…”
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Sex-dimorphic effects of glucose transporter-2 gene knockdown on hypothalamic primary astrocyte phosphoinositide-3-kinase (PI3K)/protein kinase B (PKB/Akt)/mammalian target of rapamycin (mTOR) cascade protein expression and phosphorylation by Pasula, Madhu Babu, Sapkota, Subash, Sylvester, Paul W., Briski, Karen P.

“…Glucose transporter-2 (GLUT2), a unique high capacity/low affinity, highly efficient membrane transporter and sensor, regulates hypothalamic astrocyte glucose…”
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Mechanisms Mediating the Effects of γ-Tocotrienol When Used in Combination with PPARγ Agonists or Antagonists on MCF-7 and MDA-MB-231 Breast Cancer Cells by Malaviya, Abhita, Sylvester, Paul W.

“…γ-Tocotrienol is a natural vitamin E that displays potent anticancer activity, and previous studies suggest that these effects involve alterations in PPARγ…”
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Design and pharmacophore modeling of biaryl methyl eugenol analogs as breast cancer invasion inhibitors by Abdel Bar, Fatma M., Khanfar, Mohammad A., Elnagar, Ahmed Y., Badria, Farid A., Zaghloul, Ahmed M., Ahmad, Kadria F., Sylvester, Paul W., El Sayed, Khalid A.

“…Cell invasion and migration are required for the parent solid tumor cells to metastasize to distant organs. Microtubules form a polarized network, enabling…”
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Sex-specific estrogen regulation of hypothalamic astrocyte estrogen receptor expression and glycogen metabolism in rats by Ibrahim, Mostafa M.H., Bheemanapally, Khaggeswar, Sylvester, Paul W., Briski, Karen P.

“…Brain astrocytes are implicated in estrogenic neuroprotection against bio-energetic insults, which may involve their glycogen energy reserve. Forebrain…”
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γ-Tocotrienol-induced autophagy in malignant mammary cancer cells by Tiwari, Roshan V, Parajuli, Parash, Sylvester, Paul W

“…γ-Tocotrienol, a member of the vitamin E family of compounds, displays potent antiproliferative and cytotoxic effects in a variety of cancer cell types at…”
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Synergistic anticancer effects of combined γ-tocotrienol and oridonin treatment is associated with the induction of autophagy by Tiwari, Roshan V., Parajuli, Parash, Sylvester, Paul W.

“…γ-Tocotrienol and oridonin are natural phytochemicals that display potent anticancer activity. Studies showed that combined treatment with subeffective doses…”
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