Search Results - "Sylvester, Albert J"

Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2/3: a randomised, double-blind, placebo-controlled phase 2b trial by Trimble, Cornelia L, Prof, Morrow, Matthew P, PhD, Kraynyak, Kimberly A, PhD, Shen, Xuefei, PhD, Dallas, Michael, PhD, Yan, Jian, PhD, Edwards, Lance, MD, Parker, R Lamar, MD, Denny, Lynette, MD, Giffear, Mary, BS, Brown, Ami Shah, PhD, Marcozzi-Pierce, Kathleen, MA, Shah, Divya, MS, Slager, Anna M, MS, Sylvester, Albert J, MS, Khan, Amir, PhD, Broderick, Kate E, PhD, Juba, Robert J, MSCEP, Herring, Timothy A, MPH, Boyer, Jean, PhD, Lee, Jessica, MPH, Sardesai, Niranjan Y, PhD, Weiner, David B, Prof, Bagarazzi, Mark L, MD

“…Summary Background Despite preventive vaccines for oncogenic human papillomaviruses (HPVs), cervical intraepithelial neoplasia (CIN) is common, and current…”
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Immunotherapy Targeting HPV16/18 Generates Potent Immune Responses in HPV-Associated Head and Neck Cancer by Aggarwal, Charu, Cohen, Roger B, Morrow, Matthew P, Kraynyak, Kimberly A, Sylvester, Albert J, Knoblock, Dawson M, Bauml, Joshua M, Weinstein, Gregory S, Lin, Alexander, Boyer, Jean, Sakata, Lindsay, Tan, Sophie, Anton, Aubrey, Dickerson, Kelsie, Mangrolia, Drishty, Vang, Russell, Dallas, Michael, Oyola, Sandra, Duff, Susan, Esser, Mark, Kumar, Rakesh, Weiner, David, Csiki, Ildiko, Bagarazzi, Mark L

“…Clinical responses with programmed death (PD-1) receptor-directed antibodies occur in about 20% of patients with advanced head and neck squamous cell cancer…”
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Phase 1 study of safety, tolerability and immunogenicity of the human telomerase (hTERT)-encoded DNA plasmids INO-1400 and INO-1401 with or without IL-12 DNA plasmid INO-9012 in adult patients with solid tumors by Vonderheide, Robert H, Kraynyak, Kimberly A, Shields, Anthony F, McRee, Autumn J, Johnson, Jennifer M, Sun, Weijing, Chintakuntlawar, Ashish V, Pawlicki, Jan, Sylvester, Albert J, McMullan, Trevor, Samuels, Robert, Kim, Joseph J, Weiner, David, Boyer, Jean D, Morrow, Matthew P, Humeau, Laurent, Skolnik, Jeffrey M

“…BackgroundHuman telomerase reverse transcriptase (hTERT) is frequently classified as a ‘universal’ tumor associated antigen due to its expression in a vast…”
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Immune Therapy Targeting E6/E7 Oncogenes of Human Paillomavirus Type 6 (HPV-6) Reduces or Eliminates the Need for Surgical Intervention in the Treatment of HPV-6 Associated Recurrent Respiratory Papillomatosis by Aggarwal, Charu, Cohen, Roger B, Morrow, Matthew P, Kraynyak, Kimberly A, Sylvester, Albert J, Cheung, Jocelyn, Dickerson, Kelsie, Schulten, Veronique, Knoblock, Dawson, Gillespie, Elisabeth, Bauml, Joshua M, Yan, Jian, Diehl, Malissa, Boyer, Jean, Dallas, Michael, Kim, J Joseph, Weiner, David B, Skolnik, Jeffrey M

“…Background: Recurrent respiratory papillomatosis (RRP) is a rare disorder characterized by the generation of papillomas of the aerodigestive tract, usually…”
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Augmentation of cellular and humoral immune responses to HPV16 and HPV18 E6 and E7 antigens by VGX-3100 by Morrow, Matthew P, Kraynyak, Kimberly A, Sylvester, Albert J, Shen, Xuefei, Amante, Dinah, Sakata, Lindsay, Parker, Lamar, Yan, Jian, Boyer, Jean, Roh, Christian, Humeau, Laurent, Khan, Amir S, Broderick, Kate, Marcozzi-Pierce, Kathleen, Giffear, Mary, Lee, Jessica, Trimble, Cornelia L, Kim, J Joseph, Sardesai, Niranjan Y, Weiner, David B, Bagarazzi, Mark L

“…We have previously demonstrated the immunogenicity of VGX-3100, a multicomponent DNA immunotherapy for the treatment of Human Papillomavirus…”
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Intradermal SynCon® Ebola GP DNA Vaccine Is Temperature Stable and Safely Demonstrates Cellular and Humoral Immunogenicity Advantages in Healthy Volunteers by Tebas, Pablo, Kraynyak, Kimberly A, Patel, Ami, Maslow, Joel N, Morrow, Matthew P, Sylvester, Albert J, Knoblock, Dawson, Gillespie, Elisabeth, Amante, Dinah, Racine, Trina, McMullan, Trevor, Jeong, Moonsup, Roberts, Christine C, Park, Young K, Boyer, Jean, Broderick, Kate E, Kobinger, Gary P, Bagarazzi, Mark, Weiner, David B, Sardesai, Niranjan Y, White, Scott M

“…Nonlive vaccine approaches that are simple to deliver and stable at room temperature or 2-8°C could be advantageous in controlling future Ebola virus (EBOV)…”
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Clinical and Immunologic Biomarkers for Histologic Regression of High-Grade Cervical Dysplasia and Clearance of HPV16 and HPV18 after Immunotherapy by Morrow, Matthew P, Kraynyak, Kimberly A, Sylvester, Albert J, Dallas, Michael, Knoblock, Dawson, Boyer, Jean D, Yan, Jian, Vang, Russell, Khan, Amir S, Humeau, Laurent, Sardesai, Niranjan Y, Kim, J Joseph, Plotkin, Stanley, Weiner, David B, Trimble, Cornelia L, Bagarazzi, Mark L

“…As previously reported, treatment of high-grade cervical dysplasia with VGX-3100 resulted in complete histopathologic regression (CR) concomitant with…”
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Microarray analysis of mouse ear tissue exposed to bis-(2-chloroethyl) sulfide: gene expression profiles correlate with treatment efficacy and an established clinical endpoint by Dillman, 3rd, James F, Hege, Alison I, Phillips, Christopher S, Orzolek, Linda D, Sylvester, Albert J, Bossone, Carol, Henemyre-Harris, Claudia, Kiser, Robyn C, Choi, Young W, Schlager, John J, Sabourin, Carol L

“…Bis-(2-chloroethyl) sulfide (sulfur mustard; SM) is a potent alkylating agent. Three treatment compounds have been shown to limit SM damage in the mouse ear…”
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Phase I Trial of a Therapeutic DNA Vaccine for Preventing Hepatocellular Carcinoma from Chronic Hepatitis C Virus (HCV) Infection by Jacobson, Jeffrey M, Zahrieh, David, Strand, Carrie A, Cruz-Correa, Marcia, Pungpapong, Surakit, Roberts, Lewis R, Mandrekar, Sumithra J, Rodriguez, Luz Maria, Boyer, Jean, Marrero, Idania, Kraynyak, Kimberly A, Morrow, Matthew P, Sylvester, Albert J, Pawlicki, Jan M, Gillespie, Elisabeth, Barranco, Eduardo, Richmond, Ellen, Umar, Asad, Weiner, David B, Limburg, Paul J

“…Chronic hepatitis C can lead to cirrhosis and hepatocellular carcinoma. We studied the safety and immunogenicity of a novel therapeutic hepatitis C virus (HCV)…”
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Immune Therapy Targeting E6/E7 Oncogenes of Human Papillomavirus Type 6 (HPV-6) Reduces or Eliminates the Need for Surgical Intervention in the Treatment of HPV-6 Associated Recurrent Respiratory Papillomatosis by Aggarwal, Charu, Cohen, Roger B., Morrow, Matthew P., Kraynyak, Kimberly A., Sylvester, Albert J., Cheung, Jocelyn, Dickerson, Kelsie, Schulten, Veronique, Knoblock, Dawson, Gillespie, Elisabeth, Bauml, Joshua M., Yan, Jian, Diehl, Malissa, Boyer, Jean, Dallas, Michael, Kim, J. Joseph, Weiner, David B., Skolnik, Jeffrey M.

“…Background: Recurrent respiratory papillomatosis (RRP) is a rare disorder characterized by the generation of papillomas of the aerodigestive tract, usually…”
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Genome-Wide Profiling of Oral Squamous Cell Carcinoma by Array-Based Comparative Genomic Hybridization by Sparano, Anthony, Quesnelle, Kelly M., Kumar, Madhu S., Wang, Yan, Sylvester, Albert J., Feldman, Michael, Sewell, Duane A., Weinstein, Gregory S., Brose, Marcia S.

“…Objectives: Array‐based comparative genomic hybridization (aCGH) was used to develop a genome‐wide molecular profile of oral squamous cell carcinoma (OSCC)…”
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Genomic Analysis of Rodent Pulmonary Tissue Following Bis-(2-chloroethyl) Sulfide Exposure by Dillman, James F, Phillips, Christopher S, Dorsch, Linda M, Croxton, Matthew D, Hege, Alison I, Sylvester, Albert J, Moran, Theodore S, Sciuto, Alfred M

“…Bis-(2-chloroethyl) sulfide (sulfur mustard, SM) is a carcinogenic alkylating agent that has been utilized as a chemical warfare agent. To understand the…”
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Abstract LB-144: Immunotherapy targeting PSA and PSMA in patients with biochemically recurrent prostate cancer expands antigen-specific T cell receptor repertoire in a PhI/II trial by Kraynyak, Kimberly A., Morrow, Matthew P., Sylvester, Albert J., Wani, Snehal, Boyer, Jean, Bhatt, Kamal, McMullan, Trevor, Lee, Jessica, Sacchetta, Brian, Rosencranz, Samantha, Skolnik, Jeffrey, Shore, Neal

“…Introduction: About one-third of prostate cancer (PCa) patients will experience rising prostate specific antigen levels, a condition known as biochemical…”
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Immunotherapy targeting HPV 16/18 generates potent immune responses in HPV-Associated Head and Neck Cancer by Aggarwal, Charu, Cohen, Roger B., Morrow, Matthew P., Kraynyak, Kimberly A., Sylvester, Albert J., Knoblock, Dawson M., Bauml, Joshua M., Weinstein, Gregory S., Lin, Alexander, Boyer, Jean, Sakata, Lindsay, Tan, Sophie, Anton, Aubrey, Dickerson, Kelsie, Mangrolia, Drishty, Vang, Russell, Dallas, Michael, Oyola, Sandra, Duff, Susan, Esser, Mark, Kumar, Rakesh, Weiner, David, Csiki, Ildiko, Bagarazzi, Mark L.

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Clinical and Immunologic Biomarkers for Regression of High Grade Cervical Dysplasia and Clearance of HPV16 and HPV18 Infection after Immunotherapy with VGX-3100 in a Phase IIb Clinical Trial by Morrow, Matthew P, Kraynyak, Kimberly A, Sylvester, Albert J, Dallas, Michael, Knoblock, Dawson, Boyer, Jean D, Yan, Jian, Vang, Russell, Khan, Amir, Humeau, Laurent, Sardesai, Niranjan, Kim, J Joseph, Plotkin, Stanley, Weiner, David, Trimble, Cornelia Liu, Bagarazzi, Mark

“…We have previously demonstrated proof-of-principle of VGX-3100, an immunotherapy which targets HPV16/18 E6 and E7, in a Phase IIb study in women with…”
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VGX-3100 Drives Regression of HPV16/18 CIN2/3 and Robust Cellular Immune Responses in Blood and Cervical Tissue in a Blinded, Randomized, Placebo-controlled Phase 2b Study by Morrow, Matthew P, Trimble, Connie, Shen, Xuefei, Dallas, Michael, Weiner, David, Boyer, Jean, Yan, Jian, Kraynyak, Kimberly A, Sylvester, Albert J, Giffear, Mary, Marcozzi-Pierce, Kathleen, Shah, Divya, Broderick, Kate, Khan, Amir S, Lee, Jessica, Humeau, Laurent, Sardesai, Niranjan, Bagarazzi, Mark

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Intradermal Delivery of INO-4201 Drives Robust Ebola Glycoprotein Specific Humoral and Cellular Immune Responses in Healthy Volunteers in an Open Label Phase I Trial by Kraynyak, Kimberly Ann, Amante, Dinah, Tebas, Pablo, Knoblock, Dawson, Sylvester, Albert J, Morrow, Matthew P, Prostak, Naseem, Liu, Li, Sakata, Lindsay, Cheung, Jocelyn, Desfor, Shane, Patel, Ami, Dallas, Michael, Yan, Jian, Khan, Amir, Boyer, Jean D, White, Scott, Maslow, Joel, Humeau, Laurent, Sardesai, Niranjan, Weiner, David, Bagarazzi, Mark

“…The most recent Ebola outbreak in West Africa resulted in over 28,000 suspected cases of infection and over 11,000 deaths. As no specific immune correlate has…”
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