Search Results - "Syljuasen, R. G."

Simultaneous measurement of passage through the restriction point and MCM loading in single cells by Håland, T W, Boye, E, Stokke, T, Grallert, B, Syljuåsen, R G

“…Passage through the Retinoblastoma protein (RB1)-dependent restriction point and the loading of minichromosome maintenance proteins (MCMs) are two crucial…”
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Checkpoint adaptation in human cells by SYLJUASEN, R. G

“…Checkpoint adaptation was originally described in Saccharomyces cerevisiae as the ability to divide following a sustained checkpoint arrest in the presence of…”
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The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis by Bartek, Jiri, Falck, Jacob, Mailand, Niels, Syljuåsen, Randi G, Lukas, Jiri

“…When exposed to ionizing radiation (IR), eukaryotic cells activate checkpoint pathways to delay the progression of the cell cycle. Defects in the IR-induced…”
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Rapid Destruction of Human Cdc25A in Response to DNA Damage by Mailand, Niels, Falck, Jacob, Lukas, Claudia, Syljuåsen, Randi G., Welcker, Markus, Bartek, Jiri, Lukas, Jiri

“…To protect genome integrity and ensure survival, eukaryotic cells exposed to genotoxic stress cease proliferating to provide time for DNA repair. Human cells…”
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Radiation-Induced Apoptosis and Cell Cycle Progression in Jurkat T Cells by Syljuåsen, Randi G., McBride, William H.

“…The purpose of this study was to explore the connection between radiation-induced apoptosis and progression of cells through the phases of the cell cycle…”
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Sensitization of Renal Carcinoma to Radiation Using Alpha Interferon (IFNA) Gene Transfection by Syljuåsen, Randi G., Belldegrun, Arie, Tso, Cho-Lea, Withers, H. Rodney, McBride, William H.

“…The rationale for this study was that local delivery of interferon-alpha (IFN-α) by gene transfection may be of value during radiotherapy. To investigate the…”
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Apoptosis and Delayed Expression of c-jun and c-fos after Gamma Irradiation of Jurkat T Cells by Syljuåsen, Randi G., Ji-Hong Hong, McBride, William H.

“…The purpose of this study was to determine the role of radiation-induced expression of c-jun and c-fos in radiation-induced apoptosis of cells of the Jurkat…”
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Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication by Sorensen, C. S., Syljuasen, R. G.

“…Mechanisms that preserve genome integrity are highly important during the normal life cycle of human cells. Loss of genome protective mechanisms can lead to…”
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Distinct modes of deregulation of the proto-oncogenic Cdc25A phosphatase in human breast cancer cell lines by LÖFFLER, Harald, SYLJUASEN, Randi G, BARTKOVA, Jirina, WORM, Jesper, LUKAS, Jiri, JIRI, BARTEK

“…The rapid cell cycle arrest in response to DNA damage is mediated by degradation of the Cdc25A phosphatase, a proto-oncogene whose mRNA is frequently…”
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p53-dependent G(1) arrest in 1st or 2nd cell cycle may protect human cancer cells from cell death after treatment with ionizing radiation and Chk1 inhibitors by Petersen, L, Hasvold, G, Lukas, J, Bartek, J, Syljuåsen, R G

“…This study was performed to explore the strategy of combining Chk1 inhibitors with ionizing radiation (IR) to selectively target p53-deficient cancer cells…”
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c-Abl Is Required for Development and Optimal Cell Proliferation in the Context of p53 Deficiency by Whang, Young E., Tran, Chris, Henderson, Cailin, Syljuasen, Randi G., Rozengurt, Nora, McBride, William H., Sawyers, Charles L.

“…The c-Abl tyrosine kinase and the p53 tumor suppressor protein interact functionally and biochemically in cellular genotoxic stress response pathways and are…”
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Molecular Events in Radiation Transformation by Syljuåsen, Randi G., Krolewski, Bozena, Little, John B.

“…Syljuåsen, R. G., Krolewski, B. and Little, J. B. Molecular Events in Radiation Transformation. Studies of human tumor cell lines have revealed alterations in…”
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Effects of IL-3 gene expression on tumor response to irradiation in vitro and in vivo by CHIANG, C.-S, SYLJUÄSEN, R. G, HONG, J.-H, WALLIS, A, DOUGHERTY, G. J, MCBRIDE, W. H

“…Expression of a murine interleukin 3 gene in murine fibrosarcoma cells (FSA-JmIL-3) did not alter their survival after in vitro irradiation. However,…”
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The effects of cytokine gene transfer into tumors on host cell infiltration and regression by McBride, W H, Economou, J S, Syljuåsen, R G, Parrish, C, Hackman, D, Latham, V, Chiang, C S, Dougherty, G J

“…New strategies are becoming available that promise to revolutionize cancer immunotherapy. Although the task of generating what is in essence a pathogenic…”
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The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair by Bartek, Jiri, Helleday, Thomas, Sørensen, Claus Storgaard, Hansen, Lasse Tengbjerg, Dziegielewski, Jaroslaw, Syljuåsen, Randi G, Lundin, Cecilia

“…The essential checkpoint kinase Chk1 is required for cell-cycle delays after DNA damage or blocked DNA replication. However, it is unclear whether Chk1 is…”
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Inhibition of Human Chk1 Causes Increased Initiation of DNA Replication, Phosphorylation of ATR Targets, and DNA Breakage by Syljuåsen, Randi G., Sørensen, Claus Storgaard, Hansen, Lasse Tengbjerg, Fugger, Kasper, Lundin, Cecilia, Johansson, Fredrik, Helleday, Thomas, Sehested, Maxwell, Lukas, Jiri, Bartek, Jiri

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Loss of normal G1 checkpoint control is an early step in carcinogenesis, independent of p53 status by SYLJUASEN, R. G, KROLEWSKI, B, LITTLE, J. B

“…Recent studies have described a diminished radiation-induced G1 arrest in some wild-type (wt) p53 human tumor cell lines compared to normal human fibroblasts…”
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Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase by Bartek, Jiri, Krämer, Alwin, Mailand, Niels, Lukas, Claudia, Syljuåsen, Randi G, Wilkinson, Christopher J, Nigg, Erich A, Lukas, Jiri

“…Entry into mitosis occurs after activation of Cdk1, resulting in chromosome condensation in the nucleus and centrosome separation, as well as increased…”
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ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage by Sørensen, Claus Storgaard, Syljuåsen, Randi G, Lukas, Jiri, Bartek, Jiri

“…The ATR and Chk1 kinases are essential to maintain genomic integrity. ATR, with Claspin and the Rad9-Rad1-Hus1 complex, activates Chk1 after DNA damage…”
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Inhibition of Chk1 by CEP-3891 accelerates mitotic nuclear fragmentation in response to ionizing Radiation by Syljuåsen, Randi G, Sørensen, Claus Storgaard, Nylandsted, Jesper, Lukas, Claudia, Lukas, Jiri, Bartek, Jiri

“…The human checkpoint kinase Chk1 has been suggested as a target for cancer treatment. Here, we show that a new inhibitor of Chk1 kinase, CEP-3891, efficiently…”
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