Search Results - "Syljuåsen, Randi G."

Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication by Sorensen, C. S., Syljuasen, R. G.

“…Mechanisms that preserve genome integrity are highly important during the normal life cycle of human cells. Loss of genome protective mechanisms can lead to…”
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p21 limits S phase DNA damage caused by the Wee1 inhibitor MK1775 by Hauge, Sissel, Macurek, Libor, Syljuåsen, Randi G.

“…The Wee1 inhibitor MK1775 (AZD1775) is currently being tested in clinical trials for cancer treatment. Here, we show that the p53 target and CDK inhibitor p21…”
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Hypoxia-Induced Gene Expression in Chemoradioresistant Cervical Cancer Revealed by Dynamic Contrast-Enhanced MRI by HALLE, Cathinka, ANDERSEN, Erlend, MALINEN, Eirik, LYNG, Heidi, LANDO, Malin, AARNES, Eva-Katrine, HASVOLD, Grete, HOLDEN, Marit, SYLJUASEN, Randi G, SUNDFØR, Kolbein, KRISTENSEN, Gunnar B, HOLM, Ruth

“…Knowledge of the molecular background of functional magnetic resonance (MR) images is required to fully exploit their potential in cancer management. We…”
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A novel, rapid and sensitive flow cytometry method reveals degradation of promoter proximal paused RNAPII in the presence and absence of UV by Bay, Lilli T E, Syljuåsen, Randi G, Landsverk, Helga B

“…Abstract RNA polymerase II (RNAPII) is emerging as an important factor in DNA damage responses, but how it responds to genotoxic stress is not fully…”
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Expanding roles of cell cycle checkpoint inhibitors in radiation oncology by Hauge, Sissel, Eek Mariampillai, Adrian, Rødland, Gro Elise, Bay, Lilli T. E., Landsverk, Helga B., Syljuåsen, Randi G.

“…Radiation-induced activation of cell cycle checkpoints have been of long-standing interest. The WEE1, CHK1 and ATR kinases are key factors in cell cycle…”
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Adaptation to the ionizing radiation-induced G2 checkpoint occurs in human cells and depends on checkpoint kinase 1 and polo-like kinase 1 kinases by SYLJUASEN, Randi G, JENSEN, Sanne, BARTEK, Jiri, LUKAS, Jiri

“…Checkpoint adaptation was originally defined in yeast as the ability to divide despite the presence of damaged DNA. An important unanswered question is whether…”
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Immunogenic cell death after combined treatment with radiation and ATR inhibitors is dually regulated by apoptotic caspases by Eek Mariampillai, Adrian, Hauge, Sissel, Kongsrud, Karoline, Syljuåsen, Randi G

“…Inhibitors of the ATR kinase act as radiosensitizers through abrogating the G2 checkpoint and reducing DNA repair. Recent studies suggest that ATR inhibitors…”
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WDR82/PNUTS-PP1 Prevents Transcription-Replication Conflicts by Promoting RNA Polymerase II Degradation on Chromatin by Landsverk, Helga B., Sandquist, Lise E., Bay, Lilli T.E., Steurer, Barbara, Campsteijn, Coen, Landsverk, Ole J.B., Marteijn, Jurgen A., Petermann, Eva, Trinkle-Mulcahy, Laura, Syljuåsen, Randi G.

“…Transcription-replication (T-R) conflicts cause replication stress and loss of genome integrity. However, the transcription-related processes that restrain…”
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Combined inhibition of Wee1 and Chk1 gives synergistic DNA damage in S-phase due to distinct regulation of CDK activity and CDC45 loading by Hauge, Sissel, Naucke, Christian, Hasvold, Grete, Joel, Mrinal, Rødland, Gro Elise, Juzenas, Petras, Stokke, Trond, Syljuåsen, Randi G

“…Recent studies have shown synergistic cytotoxic effects of simultaneous Chk1- and Wee1-inhibition. However, the mechanisms behind this synergy are not known…”
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The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair by Bartek, Jiri, Helleday, Thomas, Sørensen, Claus Storgaard, Hansen, Lasse Tengbjerg, Dziegielewski, Jaroslaw, Syljuåsen, Randi G, Lundin, Cecilia

“…The essential checkpoint kinase Chk1 is required for cell-cycle delays after DNA damage or blocked DNA replication. However, it is unclear whether Chk1 is…”
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Regulation of ATR activity via the RNA polymerase II associated factors CDC73 and PNUTS-PP1 by Landsverk, Helga B, Sandquist, Lise E, Sridhara, Sreerama C, Rødland, Gro Elise, Sabino, João C, de Almeida, Sérgio F, Grallert, Beata, Trinkle-Mulcahy, Laura, Syljuåsen, Randi G

“…Abstract Ataxia telangiectasia mutated and Rad3-related (ATR) kinase is a key factor activated by DNA damage and replication stress. An alternative pathway for…”
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A novel role for ATR/Rad3 in G1 phase by Bøe, Cathrine A., Håland, Tine W., Boye, Erik, Syljuåsen, Randi G., Grallert, Beáta

“…Checkpoint kinases are important in cellular surveillance pathways that help cells to cope with DNA damage and protect their genomes. In cycling cells, DNA…”
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Caspase activation counteracts interferon signaling after G2 checkpoint abrogation by ATR inhibition in irradiated human cancer cells by Eek Mariampillai, Adrian, Hauge, Sissel, Øynebråten, Inger, Rødland, Gro Elise, Corthay, Alexandre, Syljuåsen, Randi G.

“…Recent studies suggest that inhibition of the ATR kinase can potentiate radiation-induced antitumor immune responses, but the extent and mechanisms of such…”
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Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase by Beck, Halfdan, Nähse, Viola, Larsen, Marie Sofie Yoo, Groth, Petra, Clancy, Trevor, Lees, Michael, Jørgensen, Mette, Helleday, Thomas, Syljuåsen, Randi G, Sørensen, Claus Storgaard

“…Maintenance of genome integrity is of critical importance to cells. To identify key regulators of genomic integrity, we screened a human cell line with a…”
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The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis by Bartek, Jiri, Falck, Jacob, Mailand, Niels, Syljuåsen, Randi G, Lukas, Jiri

“…When exposed to ionizing radiation (IR), eukaryotic cells activate checkpoint pathways to delay the progression of the cell cycle. Defects in the IR-induced…”
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Inhibition of Human Chk1 Causes Increased Initiation of DNA Replication, Phosphorylation of ATR Targets, and DNA Breakage by Syljuåsen, Randi G., Sørensen, Claus Storgaard, Hansen, Lasse Tengbjerg, Fugger, Kasper, Lundin, Cecilia, Johansson, Fredrik, Helleday, Thomas, Sehested, Maxwell, Lukas, Jiri, Bartek, Jiri

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Potential Benefits of Combining Proton or Carbon Ion Therapy with DNA Damage Repair Inhibitors by Rødland, Gro Elise, Temelie, Mihaela, Eek Mariampillai, Adrian, Hauge, Sissel, Gilbert, Antoine, Chevalier, François, Savu, Diana I, Syljuåsen, Randi G

“…The use of charged particle radiotherapy is currently increasing, but combination therapy with DNA repair inhibitors remains to be exploited in the clinic. The…”
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PLK1-inhibition can cause radiosensitization or radioresistance dependent on the treatment schedule by Lund-Andersen, Christin, Patzke, Sebastian, Nähse-Kumpf, Viola, Syljuåsen, Randi G

“…Abstract Background and purpose PLK1-inhibitors are emerging as new potential anticancer agents. It is therefore important to explore the combined effects of…”
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SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation by Jørgensen, Stine, Eskildsen, Morten, Fugger, Kasper, Hansen, Lisbeth, Larsen, Marie Sofie Yoo, Kousholt, Arne Nedergaard, Syljuåsen, Randi G, Trelle, Morten Beck, Jensen, Ole Nørregaard, Helin, Kristian, Sørensen, Claus Storgaard

“…The eukaryotic cell cycle is regulated by multiple ubiquitin-mediated events, such as the timely destruction of cyclins and replication licensing factors. The…”
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A genetic screen identifies BRCA2 and PALB2 as key regulators of G2 checkpoint maintenance by Menzel, Tobias, Nähse-Kumpf, Viola, Kousholt, Arne Nedergaard, Klein, Ditte Kjærsgaard, Lund-Andersen, Christin, Lees, Michael, Johansen, Jens Vilstrup, Syljuåsen, Randi G, Sørensen, Claus Storgaard

“…To identify key connections between DNA‐damage repair and checkpoint pathways, we performed RNA interference screens for regulators of the ionizing…”
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