Search Results - "Sykes, A"

Investigating the Impact of Nanoparticle Size on Active and Passive Tumor Targeting Efficiency by Sykes, Edward A, Chen, Juan, Zheng, Gang, Chan, Warren C.W

“…Understanding the principles governing the design of nanoparticles for tumor targeting is essential for the effective diagnosis and treatment of solid tumors…”
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Mechanism of hard-nanomaterial clearance by the liver by Tsoi, Kim M., MacParland, Sonya A., Ma, Xue-Zhong, Spetzler, Vinzent N., Echeverri, Juan, Ouyang, Ben, Fadel, Saleh M., Sykes, Edward A., Goldaracena, Nicolas, Kaths, Johann M., Conneely, John B., Alman, Benjamin A., Selzner, Markus, Ostrowski, Mario A., Adeyi, Oyedele A., Zilman, Anton, McGilvray, Ian D., Chan, Warren C. W.

“…The liver and spleen are major biological barriers to translating nanomedicines because they sequester the majority of administered nanomaterials and prevent…”
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Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D2 receptors by Sykes, David A., Moore, Holly, Stott, Lisa, Holliday, Nicholas, Javitch, Jonathan A., Lane, J. Robert, Charlton, Steven J.

“…Atypical antipsychotic drugs (APDs) have been hypothesized to show reduced extrapyramidal side effects (EPS) due to their rapid dissociation from the dopamine…”
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The Effects of Youth Mentoring Programs: A Meta-analysis of Outcome Studies by Raposa, Elizabeth B., Rhodes, Jean, Stams, Geert Jan J. M., Card, Noel, Burton, Samantha, Schwartz, Sarah, Sykes, Laura A. Yoviene, Kanchewa, Stella, Kupersmidt, Janis, Hussain, Saida

“…Mentoring programs, which pair youth with caring, non-parental adults with the goal of promoting positive youth development, are an increasingly popular…”
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The role of kinetic context in apparent biased agonism at GPCRs by Klein Herenbrink, Carmen, Sykes, David A., Donthamsetti, Prashant, Canals, Meritxell, Coudrat, Thomas, Shonberg, Jeremy, Scammells, Peter J., Capuano, Ben, Sexton, Patrick M., Charlton, Steven J., Javitch, Jonathan A., Christopoulos, Arthur, Lane, J. Robert

“…Biased agonism describes the ability of ligands to stabilize different conformations of a GPCR linked to distinct functional outcomes and offers the prospect…”
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Tailoring nanoparticle designs to target cancer based on tumor pathophysiology by Sykes, Edward A., Dai, Qin, Sarsons, Christopher D., Chen, Juan, Rocheleau, Jonathan V., Hwang, David M., Zheng, Gang, Cramb, David T., Rinker, Kristina D., Chan, Warren C. W.

“…Nanoparticles can provide significant improvements in the diagnosis and treatment of cancer. How nanoparticle size, shape, and surface chemistry can affect…”
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Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction by Dunham-Snary, Kimberly J, Wu, Danchen, Potus, François, Sykes, Edward A, Mewburn, Jeffrey D, Charles, Rebecca L, Eaton, Philip, Sultanian, Richard A, Archer, Stephen L

“…RATIONALE:Hypoxic pulmonary vasoconstriction (HPV) optimizes systemic oxygen delivery by matching ventilation to perfusion. HPV is intrinsic to pulmonary…”
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The impact of obstructive sleep apnea on exercise capacity in a cardiac rehabilitation program by Sonners, C., Schmickl, C. N., Raphelson, J., Sykes, A. V., Roberts, E. G., Swiatkiewicz, I., Malhotra, A., Taub, P. R.

“…Purpose Cardiac rehabilitation (CR) improves clinical outcomes in patients with cardiovascular disease (CDV). Patients with CVD often have multiple…”
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Anisotropic Expansion of a Thermal Dipolar Bose Gas by Tang, Y, Sykes, A G, Burdick, N Q, DiSciacca, J M, Petrov, D S, Lev, B L

“…We report on the anisotropic expansion of ultracold bosonic dysprosium gases at temperatures above quantum degeneracy and develop a quantitative theory to…”
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Electrochemotherapy in the treatment of metastatic malignant melanoma: a prospective cohort study by InspECT by Kunte, C., Letulé, V., Gehl, J., Dahlstroem, K., Curatolo, P., Rotunno, R., Muir, T., Occhini, A., Bertino, G., Powell, B., Saxinger, W., Lechner, G., Liew, S.‐H., Pritchard‐Jones, R., Rutkowski, P., Zdzienicki, M., Mowatt, D., Sykes, A.J., Orlando, A., Mitsala, G., Rossi, C.R., Campana, L., Brizio, M., de Terlizzi, F., Quaglino, P., Odili, J.

“…Summary Background (ECT) is an effective local treatment for cutaneous metastasis. Treatment involves the administration of chemotherapeutic drugs followed by…”
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Impaired innate interferon induction in severe therapy resistant atopic asthmatic children by Edwards, M R, Regamey, N, Vareille, M, Kieninger, E, Gupta, A, Shoemark, A, Saglani, S, Sykes, A, Macintyre, J, Davies, J, Bossley, C, Bush, A, Johnston, S L

“…Deficient type I interferon-β and type III interferon-λ induction by rhinoviruses has previously been reported in mild/moderate atopic asthmatic adults. No…”
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Reducing Delay From Referral to Admission at a U.S. First-Episode Psychosis Service: A Quality Improvement Initiative by Ferrara, Maria, Gallagher, Keith, Yoviene Sykes, Laura A., Markovich, Philip, Li, Fangyong, Pollard, Jessica M., Imetovski, Shannon, Cahill, John, Guloksuz, Sinan, Srihari, Vinod H.

“…Duration of untreated psychosis (DUP), the period between psychosis onset and entry into care, is a time of great vulnerability. Longer DUP predicts poorer…”
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Electrochemotherapy and Ablative Therapies in Non-melanoma Skin Cancer by O'Donoghue, N., Mowatt, D., Sykes, A.J.

“…Although surgery and radiotherapy remain the most commonly used treatments for non-melanoma skin cancer, there are a variety of alternatives. Here we discuss…”
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The Influence of receptor kinetics on the onset and duration of action and the therapeutic index of NVA237 and tiotropium by Sykes, David A, Dowling, Mark R, Leighton-Davies, Juliet, Kent, Toby C, Fawcett, Lindsay, Renard, Emilie, Trifilieff, Alexandre, Charlton, Steven J

“…Studies under nonphysiological conditions suggest that long receptor residency time is responsible for the 24-h duration of action of the long-acting…”
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How can Never Event data be used to reflect or improve hospital safety performance? by Olivarius‐McAllister, J., Pandit, M., Sykes, A., Pandit, J. J.

“…Summary The absolute number of Never Events is used by UK regulators to help assess hospital safety performance, without account of hospital workload. We…”
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Observed drug-receptor association rates are governed by membrane affinity: the importance of establishing "micro-pharmacokinetic/pharmacodynamic relationships" at the β2-adrenoceptor by Sykes, David A, Parry, Cheryl, Reilly, John, Wright, Penny, Fairhurst, Robin A, Charlton, Steven J

“…Current pharmacological models for determining affinity and kinetics of drugs for membrane receptors assume the interacting molecules are homogeneously…”
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Exploring the mechanism of agonist efficacy: a relationship between efficacy and agonist dissociation rate at the muscarinic M3 receptor by Sykes, David A, Dowling, Mark R, Charlton, Steven J

“…Although there are several empirical approaches that enable the comparison of relative agonist efficacy, the molecular basis that underlies differences in the…”
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A phase I dose escalation and expansion trial of the next-generation oral SERD camizestrant in women with ER-positive, HER2-negative advanced breast cancer: SERENA-1 monotherapy results by Hamilton, E, Oliveira, M, Turner, N, García-Corbacho, J, Hernando, C, Ciruelos, E M, Kabos, P, Ruiz-Borrego, M, Armstrong, A, Patel, M R, Vaklavas, C, Twelves, C, Boni, V, Incorvati, J, Brier, T, Gibbons, L, Klinowska, T, Lindemann, J P O, Morrow, C J, Sykes, A, Baird, R D

“…SERENA-1 (NCT03616587) is a phase I, multi-part, open-label study of camizestrant in pre- and post-menopausal women with estrogen receptor-positive (ER+),…”
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Ablation of Proliferating Osteoblast Lineage Cells After Fracture Leads to Atrophic Nonunion in a Mouse Model by Hixon, Katherine R., McKenzie, Jennifer A., Sykes, David A.W., Yoneda, Susumu, Hensley, Austin, Buettmann, Evan G., Zheng, Hongjun, Skouteris, Dimitrios, McAlinden, Audrey, Miller, Anna N., Silva, Matthew J.

“…ABSTRACT Nonunion is defined as the permanent failure of a fractured bone to heal, often necessitating surgical intervention. Atrophic nonunions are a subtype…”
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Yellow oleander (Thevetia peruviana) toxicosis in 4 goats by Sykes, Chelsea A., Filigenzi, Michael, Uzal, Francisco A., Poppenga, Robert H.

“…Four alpine goats developed diarrhea soon after the owner placed plant clippings believed to be yellow oleander (Thevetia peruviana) into their pen on a…”
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