Search Results - "Syedain, Zeeshan H"

Cyclic distension of fibrin-based tissue constructs: Evidence of adaptation during growth of engineered connective tissue by Syedain, Zeeshan H, Weinberg, Justin S, Tranquillo, Robert T

“…Tissue engineering provides a means to create functional living tissue replacements. Here, we examine the effects of 3 weeks of cyclic distension (CD) on…”
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Controlled cyclic stretch bioreactor for tissue-engineered heart valves by Syedain, Zeeshan H, Tranquillo, Robert T

“…Abstract A tissue-engineered heart valve (TEHV) represents the ultimate valve replacement, especially for juvenile patients given its growth potential. To…”
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Evaluation of an engineered vascular graft exhibiting somatic growth in lambs to model repair of absent pulmonary artery branch by Syedain, Zeeshan H., Lahti, Matthew, Hiremath, Gurumurthy, Berry, James, Carney, John P., Schappa Faustich, Jill, Shannon, Tate, Rivera, Andrea, Wiputra, Hadi, Shi, Zhitian, Bianco, Richard, MacIver, Robroy, Mayer, John E., Tranquillo, Robert T.

“…Background Growth is the holy grail of tissue implants in pediatrics. No vascular graft currently in use for surgical repairs of congenital heart defects has…”
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Implantable arterial grafts from human fibroblasts and fibrin using a multi-graft pulsed flow-stretch bioreactor with noninvasive strength monitoring by Syedain, Zeeshan H, Meier, Lee A, Bjork, Jason W, Lee, Ann, Tranquillo, Robert T

“…Abstract Tissue-engineered arteries based on entrapment of human dermal fibroblasts in fibrin gel yield completely biological vascular grafts that possess…”
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A completely biological "off-the-shelf" arteriovenous graft that recellularizes in baboons by Syedain, Zeeshan H, Graham, Melanie L, Dunn, Ty B, O'Brien, Timothy, Johnson, Sandra L, Schumacher, Robert J, Tranquillo, Robert T

“…Prosthetic arteriovenous grafts (AVGs) conventionally used for hemodialysis are associated with inferior primary patency rates and increased risk of infection…”
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Pediatric tri-tube valved conduits made from fibroblast-produced extracellular matrix evaluated over 52 weeks in growing lambs by Syedain, Zeeshan H, Haynie, Bee, Johnson, Sandra L, Lahti, Matthew, Berry, James, Carney, John P, Li, Jirong, Hill, Ryan C, Hansen, Kirk C, Thrivikraman, Greeshma, Bianco, Richard, Tranquillo, Robert T

“…There is a need for replacement heart valves that can grow with children. We fabricated tubes of fibroblast-derived collagenous matrix that have been shown to…”
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Evaluation of the probe burst test as a measure of strength for a biologically-engineered vascular graft by Syedain, Zeeshan H., Prunty, Abrielle, Li, Jirong, Tranquillo, Robert T.

“…Biologically-engineered vascular grafts have the potential to provide a viable alternative to donor vessels and synthetic grafts. In congenital heart defect…”
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Implantation of completely biological engineered grafts following decellularization into the sheep femoral artery by Syedain, Zeeshan H, Meier, Lee A, Lahti, Mathew T, Johnson, Sandra L, Tranquillo, Robert T

“…The performance of completely biological, decellularized engineered allografts in a sheep model was evaluated to establish clinical potential of these unique…”
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Decellularized tissue-engineered heart valve leaflets with recellularization potential by Syedain, Zeeshan H, Bradee, Allison R, Kren, Stefan, Taylor, Doris A, Tranquillo, Robert T

“…Tissue-engineered heart valves (TEHV) have been proposed as a promising solution for the clinical needs of pediatric patients. In vivo studies have shown TEHV…”
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Vascular grafts and valves that animate, made from decellularized biologically-engineered tissue tubes by Syedain, Zeeshan H, Maciver, Robroy, Tranquillo, Robert T

“…Biologically-engineered matrix - a tissue that is grown in vitro from donor cells, decellularized, and stored prior to use as off-the-shelf allografts - offers…”
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Tissue-engineered transcatheter vein valve by Syedain, Zeeshan H., Jenson, Anders C., Patel, Puja S., Feagler, Cole, Bahmer, Logan, Faizer, Rumi, Tranquillo, Robert T.

“…Chronic venous insufficiency affects over 2 million patients in the US alone, with severe cases involving thousands of patients with chronic leg ulcers and…”
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Pediatric tubular pulmonary heart valve from decellularized engineered tissue tubes by Reimer, Jay M, Syedain, Zeeshan H, Haynie, Bee H.T, Tranquillo, Robert T

“…Abstract Pediatric patients account for a small portion of the heart valve replacements performed, but a pediatric pulmonary valve replacement with growth…”
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Biologically-engineered mechanical model of a calcified artery by Thrivikraman, Greeshma, Johnson, Sandra L., Syedain, Zeeshan H., Hill, Ryan C., Hansen, Kirk C., Lee, Han Seung, Tranquillo, Robert T.

“…Vascular calcification is a commonly occurring pathological process and is recognized as an independent prognostic marker for cardiovascular morbidity and…”
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Tubular Heart Valves from Decellularized Engineered Tissue by Syedain, Zeeshan H., Meier, Lee A., Reimer, Jay M., Tranquillo, Robert T.

“…A novel tissue-engineered heart valve (TEHV) was fabricated from a decellularized tissue tube mounted on a frame with three struts, which upon back-pressure…”
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TGF-β1 diminishes collagen production during long-term cyclic stretching of engineered connective tissue: Implication of decreased ERK signaling by Syedain, Zeeshan H, Tranquillo, Robert T

“…Abstract Cyclic stretching and growth factors like TGF-β have been used to enhance extracellular matrix (ECM) production by cells in engineered tissue to…”
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In Vitro Evaluation of a Device for Intra-Pulmonary Aerosol Generation and Delivery by Syedain, Zeeshan H., Naqwi, Amir A., Dolovich, Myrna, Somani, Arif

“…For infants born with respiratory distress syndrome (RDS), liquid bolus delivery of surfactant administered through an endotracheal tube is common practice…”
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Controlled compaction with ruthenium-catalyzed photochemical cross-linking of fibrin-based engineered connective tissue by Syedain, Zeeshan H, Bjork, Jason, Sando, Lillian, Tranquillo, Robert T

“…Abstract Tissue engineering utilizing fibrin gel as a scaffold has the advantage of creating a completely biological replacement. Cells seeded in a fibrin gel…”
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Blood Outgrowth Endothelial Cells Alter Remodeling of Completely Biological Engineered Grafts Implanted into the Sheep Femoral Artery by Meier, Lee A., Syedain, Zeeshan H., Lahti, Matthew T., Johnson, Sandra S., Chen, Minna H., Hebbel, Robert P., Tranquillo, Robert T.

“…Hemocompatibility of tissue-engineered vascular grafts remains a major hurdle to clinical utility for small-diameter grafts. Here we assessed the feasibility…”
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Hypoxic culture and insulin yield improvements to fibrin-based engineered tissue by Bjork, Jason W, Meier, Lee A, Johnson, Sandra L, Syedain, Zeeshan H, Tranquillo, Robert T

“…We examined the effect of insulin supplementation and hypoxic culture (2% vs. 20% oxygen tension) on collagen deposition and mechanical properties of…”
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Protein Fouling of Virus Filtration Membranes: Effects of Membrane Orientation and Operating Conditions by Syedain, Zeeshan H., Bohonak, David M., Zydney, Andrew L.

“…The capacity of virus filters used in the purification of therapeutic proteins is determined by the rate and extent of membrane fouling. Current virus…”
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