Search Results - "Syed, Muzeeb"

Mitochondrial toxicity of diclofenac and its metabolites via inhibition of oxidative phosphorylation (ATP synthesis) in rat liver mitochondria: Possible role in drug induced liver injury (DILI) by Syed, Muzeeb, Skonberg, Christian, Hansen, Steen Honoré

“…Diclofenac is a widely prescribed NSAID, which by itself and its reactive metabolites (Phase-I and Phase-II) may be involved in serious idiosyncratic…”
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A comprehensive review of the published assays for the quantitation of the immunosuppressant drug mycophenolic acid and its glucuronidated metabolites in biological fluids by Syed, Muzeeb, Srinivas, Nuggehally R.

“…Therapeutic use of mycophenolic acid (MPA) is steadily on the rise in combination with other immunosuppressant drugs in transplantation patients. The…”
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Mitochondrial toxicity of selective COX-2 inhibitors via inhibition of oxidative phosphorylation (ATP synthesis) in rat liver mitochondria by Syed, Muzeeb, Skonberg, Christian, Hansen, Steen Honoré

“…Cyclooxygenase-2 (COX-2) inhibitors (coxibs) are non-steroidal anti-inflammatory drugs (NSAIDs) designed to selectively inhibit COX-2. However, drugs of this…”
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Review of the bioanalytical methods for the determination of methotrexate and its metabolites in in vitro, preclinical and clinical studies: Case studies and perspectives by Patel, Harilal, Giri, Poonam, Ghoghari, Ashok, Delvadia, Prashant, Syed, Muzeeb, Srinivas, Nuggehally R.

“…Methotrexate is an old drug that has found use in several therapeutic areas, such as cancer to treat various malignancies, rheumatoid arthtritis and…”
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Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists by Sasmal, Sanjita, Balaji, Gade, Kanna Reddy, Hariprasada R., Balasubrahmanyam, D., Srinivas, Gujjary, Kyasa, Shiva K., Sasmal, Pradip K., Khanna, Ish, Talwar, Rashmi, Suresh, J., Jadhav, Vikram P., Muzeeb, Syed, Shashikumar, Dhanya, Harinder Reddy, K., Sebastian, V.J., Frimurer, Thomas M., Rist, Øystein, Elster, Lisbeth, Högberg, Thomas

“…The receptor model-supported design, synthesis and multi-parameter optimization of novel quinazoline derivatives as MCHR1 antagonists are described. The in…”
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Analysis of five HMG-CoA reductase inhibitors- atorvastatin, lovastatin, pravastatin, rosuvastatin and simvastatin: pharmacological, pharmacokinetic and analytical overview and development of a new method for use in pharmaceutical formulations analysis and in vitro metabolism studies by Pasha, Md. Khalid, Muzeeb, Syed, Basha, Shaik Jafar Sadik, Shashikumar, Dhanya, Mullangi, Ramesh, Srinivas, Nuggehally R.

“…A specific, accurate, precise and reproducible high‐performance liquid chromatographic (HPLC) method was developed and validated for the simultaneous…”
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Concurrent determination of ezetimibe and its phase-I and II metabolites by HPLC with UV detection: Quantitative application to various in vitro metabolic stability studies and for qualitative estimation in bile by Basha, Shaik Jafar Sadik, Naveed, Shaik Abdul, Tiwari, Nirbhay Kumar, Shashikumar, Dhanya, Muzeeb, Syed, Kumar, Thammera Ranjith, Kumar, Nyavanandi Vijay, Rao, Nadipalli Prabhakar, Srinivas, Nanduri, Mullangi, Ramesh, Srinivas, Nuggehally R.

“…Simultaneous separation and quantification of ezetimibe (EZM) and its phase-I metabolite i.e., ezetimibe ketone (EZM-K) and phase-II metabolite i.e., ezetimibe…”
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Applicability of a Single Time Point Strategy for the Prediction of Area Under the Concentration Curve of Linezolid in Patients: Superiority of C trough- over C max-Derived Linear Regression Models by Srinivas, Nuggehally R., Syed, Muzeeb

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Area under the curve predictions of dalbavancin, a new lipoglycopeptide agent, using the end of intravenous infusion concentration data point by regression analyses such as linear, log-linear and power models by Bhamidipati, Ravi Kanth, Syed, Muzeeb, Mullangi, Ramesh, Srinivas, Nuggehally

“…1. Dalbavancin, a lipoglycopeptide, is approved for treating gram-positive bacterial infections. Area under plasma concentration versus time curve (AUC inf )…”
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Inhibition of ATP synthesis by fenbufen and its conjugated metabolites in rat liver mitochondria by Syed, Muzeeb, Skonberg, Christian, Hansen, Steen Honoré

“…Fenbufen is an arylpropionic acid derivative belonging to the group of non-steroidal anti-inflammatory drugs (NSAIDs). Even though fenbufen is considered a…”
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Effect of some organic solvents on oxidative phosphorylation in rat liver mitochondria: Choice of organic solvents by Syed, Muzeeb, Skonberg, Christian, Hansen, Steen Honoré

“…•Commonly used organic solvents inhibited oxidative phosphorylation (ATP synthesis) in rat liver mitochondria.•Acetonitrile and acetone were strong inhibitors…”
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Applicability of a Single Time Point Strategy for the Prediction of Area Under the Concentration Curve of Linezolid in Patients: Superiority of C ^sub trough^- over C ^sub max^-Derived Linear Regression Models by Srinivas, Nuggehally R, Syed, Muzeeb

“…Background and Objectives Linezolid, a oxazolidinone, was the first in class to be approved for the treatment of bacterial infections arising from both…”
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Applicability of a Single Time Point Strategy for the Prediction of Area Under the Concentration Curve of Linezolid in Patients: Superiority of Ctrough- over Cmax-Derived Linear Regression Models by Srinivas, Nuggehally R., Syed, Muzeeb

“…Background and Objectives Linezolid, a oxazolidinone, was the first in class to be approved for the treatment of bacterial infections arising from both…”
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Clinical Drug–Drug Pharmacokinetic Interaction Potential of Sucralfate with Other Drugs: Review and Perspectives by Sulochana, Suresh P., Syed, Muzeeb, Chandrasekar, Devaraj V., Mullangi, Ramesh, Srinivas, Nuggehally R.

“…Sucralfate, a complex of aluminium hydroxide with sulfated sucrose, forms a strong gastrointestinal tract (GIT) mucosal barrier with excellent anti-ulcer…”
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Intranasal Pharmacokinetic Data for Triptans Such as Sumatriptan and Zolmitriptan Can Render Area Under the Curve (AUC) Predictions for the Oral Route: Strategy Development and Application by Srinivas, Nuggehally R., Syed, Muzeeb

“…Limited pharmacokinetic sampling strategy may be useful for predicting the area under the curve (AUC) for triptans and may have clinical utility as a…”
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Discovery of novel, orally available benzimidazoles as melanin concentrating hormone receptor 1 (MCHR1) antagonists by Sasmal, Pradip K., Sasmal, Sanjita, Rao, P. Tirumala, Venkatesham, B., Roshaiah, M., Abbineni, Chandrasekhar, Khanna, Ish, Jadhav, Vikram P., Suresh, J., Talwar, Rashmi, Muzeeb, Syed, Receveur, Jean-Marie, Frimurer, Thomas M., Rist, Øystein, Elster, Lisbeth, Högberg, Thomas

“…The synthesis and biological evaluation of novel benzimidazole derivatives as MCHR1 antagonists are described. The in vivo proof of principle for weight loss…”
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Glucuronidation of DRF-6574, hydroxy metabolite of DRF-4367 (a novel COX-2 inhibitor) by pooled human liver, intestinal microsomes and recombinant human UDP-glucuronosyltransferases (UGT) : Role of UGT1A1,1A3 and 1A8 by MUZEEB, Syed, SHAIK JAFAR SADIK BASHA, SHASHIKUMAR, Dhanya, MULLANGI, Ramesh, SRINIVAS, Nuggehally R

“…DRF-4367 is a novel COX-2 inhibitor, which showed good efficacy in several animal models of inflammation. In a comparative in vitro metabolism in various liver…”
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Effect of ultraviolet B (302 nm) irradiation on viability, metabolic and detoxification functions of goat hepatocytes--in vitro study by Shakeel, Naseem Begum, Venkateshan, Vijayalakshmi, Parveen, Capoor, Adarsh K, Habeeb, Mohammed Aejaz, Khan, Ansar Ali, Muzeeb, Syed, Mamidi, N V S Rao, Khan, Aleem Ahmed, Habibullah, Chittoor Mohammed

“…The object of the present study was to investigate the effect(s) of UV-B irradiation on the functional integrity, metabolic and detoxifying capacity of the…”
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Species difference in the in vitro and in vivo metabolism of amtolmetin guacil by Hotha, Kishore Kumar, Dasari, Vijaya Bharathi, Shaik, Abdul Naveed, Syed, Muzeeb, Shivva, Vittal, Lakshmanarao, Ravindranath Krishnarao, Korlakunta, Jayaveera Narasimhulu, Mullangi, Ramesh

“…Abstract Tolmetin (TMT, CAS 26171-23-3) is a non-steroidal anti-inflammatory drug (NSAID) indicated for the relief of signs and symptoms of osteoarthritis,…”
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