Search Results - "Sydow, Saskia"

Identification of Targetable Lesions in Anaplastic Thyroid Cancer by Genome Profiling by Ravi, Naveen, Yang, Minjun, Gretarsson, Sigurdur, Jansson, Caroline, Mylona, Nektaria, Sydow, Saskia R, Woodward, Eleanor L, Ekblad, Lars, Wennerberg, Johan, Paulsson, Kajsa

“…Anaplastic thyroid cancer (ATC) is a rare and extremely malignant tumor with no available cure. The genetic landscape of this malignancy has not yet been fully…”
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MDM2 amplification in rod-shaped chromosomes provides clues to early stages of circularized gene amplification in liposarcoma by Sydow, Saskia, Piccinelli, Paul, Mitra, Shamik, Tsagkozis, Panagiotis, Hesla, Asle, B. R. De Mattos, Camila, Köster, Jan, Magnusson, Linda, Nilsson, Jenny, Ameur, Adam, Wardenaar, René, Foijer, Floris, Spierings, Diana, Mertens, Fredrik

“…Well-differentiated liposarcoma (WDLS) displays amplification of genes on chromosome 12 (Chr12) in supernumerary ring or giant marker chromosomes. These…”
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Structural Variants in the SMC1A Gene Associated With Near‐Haploidy in Undifferentiated Pleomorphic Sarcomas by Ibstedt, Sebastian, Piccinelli, Paul, Sydow, Saskia, Köster, Jan, Mertens, Fredrik

“…ABSTRACT Near‐haploidization, that is, loss of one copy of most chromosomes, is a relatively rare phenomenon in most tumors, but is enriched among certain soft…”
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Insertion of the CXXC domain of KMT2A into YAP1: An unusual mechanism behind the formation of a chimeric oncogenic protein by Teku, Gabriel, Nilsson, Jenny, Magnusson, Linda, Sydow, Saskia, Flucke, Uta, Puls, Florian, Mitra, Shamik, Mertens, Fredrik

“…Most neoplasia-associated gene fusions are formed through the fusion of the 5'-part of one gene with the 3'-part of another. We here describe a unique…”
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Recurrent Fusions Between YAP1 and KMT2A in Morphologically Distinct Neoplasms Within the Spectrum of Low-grade Fibromyxoid Sarcoma and Sclerosing Epithelioid Fibrosarcoma by Puls, Florian, Agaimy, Abbas, Flucke, Uta, Mentzel, Thomas, Sumathi, Vaiyapuri P., Ploegmakers, Marieke, Stoehr, Robert, Kindblom, Lars-Gunnar, Hansson, Magnus, Sydow, Saskia, Arbajian, Elsa, Mertens, Fredrik

“…Sclerosing epithelioid fibrosarcoma (SEF) is an aggressive soft tissue sarcoma. In the majority of cases, there is overexpression of MUC4, and most cases show…”
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Transcriptomic profiles of myxofibrosarcoma and undifferentiated pleomorphic sarcoma correlate with clinical and genomic features by Mitra, Shamik, Farswan, Akanksha, Piccinelli, Paul, Sydow, Saskia, Hesla, Asle, Tsagkozis, Panagiotis, Vult von Steyern, Fredrik, Almqvist, Martin, Eriksson, Mikael, Magnusson, Linda, Nilsson, Jenny, Pillay, Nischalan, Mertens, Fredrik

“…Myxofibrosarcoma (MFS) and undifferentiated pleomorphic sarcoma (UPS) are two common and aggressive subtypes of soft tissue sarcoma. The aim of this study was…”
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Amplification of ERBB2 (HER2) in embryonal rhabdomyosarcoma: A potential treatment target in rare cases? by Mitra, Shamik, Sydow, Saskia, Magnusson, Linda, Piccinelli, Paul, Törnudd, Lisa, Øra, Ingrid, Ljungman, Gustaf, Sandgren, Johanna, Gisselsson, David, Mertens, Fredrik

“…The ERBB2 gene encodes a receptor tyrosine kinase also known as HER2. The gene is amplified and overexpressed in one‐fifth of breast carcinomas; patients with…”
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Genomic and transcriptomic characterization of desmoplastic small round cell tumors by Sydow, Saskia, Versleijen‐Jonkers, Yvonne M. H., Hansson, Magnus, Erp, Anke E. M., Hillebrandt‐Roeffen, Melissa H. S., Graaf, Winette T. A., Piccinelli, Paul, Rissler, Pehr, Flucke, Uta E., Mertens, Fredrik

“…Desmoplastic small round cell tumor (DSRCT) is a highly aggressive soft tissue tumor primarily affecting children and young adults. Most cases display a…”
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Bortezomib sensitivity is tissue dependent and high expression of the 20S proteasome precludes good response in malignant pleural mesothelioma by Walter, Robert Fred Henry, Sydow, Saskia Roxanne, Berg, Erika, Kollmeier, Jens, Christoph, Daniel Christian, Christoph, Sandra, Eberhardt, Wilfried Ernst Erich, Mairinger, Thomas, Wohlschlaeger, Jeremias, Schmid, Kurt Werner, Mairinger, Fabian Dominik

“…Bortezomib is an approved proteasome inhibitor for the treatment of certain lymphoma subtypes. Two clinical trials investigated bortezomib in patients with…”
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