Search Results - "Sychev, DA"

CYP2C1917 May Increase the Risk of Death Among Patients with an Acute Coronary Syndrome and Non-Valvular Atrial Fibrillation Who Receive Clopidogrel and Rivaroxaban by Sychev, D A, Baturina, O A, Mirzaev, K B, Rytkin, E, Ivashchenko, D V, Andreev, D A, Ryzhikova, K A, Grishina, E A, Bochkov, P O, Shevchenko, R V

“…The aim of this study is to assess the influence of gene and polymorphisms on clopidogrel antiplatelet activity, rivaroxaban concentration equilibrium, and…”
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The frequency of CYP2C19 genetic polymorphisms in Russian patients with peptic ulcers treated with proton pump inhibitors by Sychev, D A, Denisenko, N P, Sizova, Z M, Grachev, A V, Velikolug, K A

“…Proton pump inhibitors, which are widely used as acid-inhibitory agents for the treatment of peptic ulcers, are mainly metabolized by 2C19 isoenzyme of…”
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The cytochrome P450 isoenzyme and some new opportunities for the prediction of negative drug interaction in vivo by Sychev, Dmitrij A, Ashraf, Ghulam Md, Svistunov, Andrey A, Maksimov, Maksim L, Tarasov, Vadim V, Chubarev, Vladimir N, Otdelenov, Vitalij A, Denisenko, Natal'ja P, Barreto, George E, Aliev, Gjumrakch

“…Cytochrome (CYP) 450 isoenzymes are the basic enzymes involved in Phase I biotransformation. The most important role in biotransformation belongs to CYP3A4,…”
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CYP3A422 and CYP3A53 impact efficacy and safety of diazepam in patients with alcohol withdrawal syndrome by Skryabin, Valentin Yurievich, Franck, Johan, Lauschke, Volker Martin, Zastrozhin, Mikhail Sergeevich, Shipitsyn, Valery Valerievich, Bryun, Evgeny Alekseevich, Sychev, Dmitry Alekseevich

“…Diazepam is one of the most commonly prescribed pharmaceuticals for the treatment of alcohol withdrawal syndrome (AWS). However, diazepam sometimes is…”
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Effects of CYP2D6 activity on the efficacy and safety of mirtazapine in patients with depressive disorders and comorbid alcohol use disorder by Zastrozhin, M S, Skryabin, V Y, Smirnov, V V, Grishina, E A, Ryzhikova, K A, Chumakov, E M, Bryun, E A, Sychev, D A

“…The objective of the study was to investigate the effects of CYP2D6 activity on the efficacy and safety of mirtazapine in patients with depressive disorders…”
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Gene Polymorphism C3435T For ABCB1 and Antihypertensive Efficacy, Safety of The Amlodipine At The Russians Hypertensive Patients by Sychev, D.A, Shih, N.V, Grishina, E.A, Ryzhikova, K.A, Morozova, T.E

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The impact of ABCB1 (rs1045642 and rs4148738) and CES1 (rs2244613) gene polymorphisms on dabigatran equilibrium peak concentration in patients after total knee arthroplasty by Sychev, Dmitriy Alekseevich, Levanov, Alexander Nikolaevich, Shelekhova, Tatiana Vladimirovna, Bochkov, Pavel Olegovich, Denisenko, Natalia Pavlovna, Ryzhikova, Kristina Anatolyevna, Mirzaev, Karin Badavievich, Grishina, Elena Anatolyevna, Gavrilov, Mikhail Alekseevich, Ramenskaya, Galina Vladislavovna, Kozlov, Aleksei Vladimirovich, Bogoslovsky, Tanya

“…Non-vitamin K oral anticoagulants (NOACs) are commonly used for prophylaxis of venous thromboembolism (VTE) in orthopedic patients. Despite known safety and…”
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Influence of ABCB1 and CYP3A5 gene polymorphisms on pharmacokinetics of apixaban in patients with atrial fibrillation and acute stroke by Kryukov, Alexander Valerevich, Sychev, Dmitry Alekseevich, Andreev, Denis Anatolevich, Ryzhikova, Kristina Anatolievna, Grishina, Elena Anatolievna, Ryabova, Anastasia Vladislavovna, Loskutnikov, Mark Alekseevich, Smirnov, Valeriy Valerevich, Konova, Olga Dmitrievna, Matsneva, Irina Andreevna, Bochkov, Pavel Olegovich

“…Difficulties in non-vitamin K anticoagulant (NOAC) administration in acute stroke can be associated with changes in pharmacokinetic parameters of NOAC such as…”
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The Association of the rs2108622 Single Nucleotide Polymorphism in the CYP4F2 Gene with Resistance to Clopidogrel by Konova, O.D, Mirzaev, K.B, Ryzhikova, K.A, Sozaeva, Zh.A, Andreev, D.A, Sychev, D.A

“…The aim of the study was to determine the impact of carriership of at least one CYP4F2*3 allele on the risk of resistance to clopidogrel in patients with acute…”
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Assessment of CYP2C19, ABCB1, CYP3A5 Genes Polymorphisms’ and CYP3A4 Isoenzyme Activity Influence on Major Adverse Cardiovascular Events Among Patients with an Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention by Rytkin, E, Mirzaev, K.B, Smirnov, V.V, Ryzhikova, K.A, Sozaeva, Zh.A, Andreev, D.A, Sychev, D.A

“…Background The aim of this study was to determine the impact of CYP2C19, ABCB1, CYP3A5 genes polymorphisms and CYP3A4 isoenzyme activity on clopidogrel…”
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Pheno- and genotyping the prescription of drugs metabolized by CYP2D6 by Ramenskaya, G V, Savchenko, A Yu, Agafonov, A A, Sychev, D A, Andreev, D A, Kukes, V G

“…Mutant alleles CYP2D63 and CYP2D64 were detected by PCR in 33 individuals. All examinees were given 50 mg methoprolol (orally). Plasma concentrations of the…”
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Effect of Pharmacogenetic-Based Dosing of Warfarin on Bleeding During Anticoagulation in Russian Patients: A Systematic Review and Meta-Analysis by Ivashchenko, D.V, Rusin, I.V, Sychev, D.A

“…To summarize the current evidence supporting the use of genetic testing before prescribing warfarin, we performed a meta-analysis of Russian prospective…”
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The Frequency of Cyp2c19 Genetic Polymorphisms In Russian Patients With Peptic Ulcer Treated With Proton Pump Inhibitors by Denisenko, N.P, Sychev, D.A, Sizova, Zh.M, Grachev, A.V, Velikolug, K.A

“…Conclusion There is a high frequency of CYP2C19 genotypes associated with modified response on proton pump inhibitors in Russian patients with peptic ulcer…”
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Possibilities of optimization of statin Therapy based on genotyping SLCO1B1 and CYP2C9 at patients with Cardiovascular disease by Sirotkina, A.M, Khokhlov, A.A, Voronina, E.A, Sychev, D.A

“…The aim was to determine the frequency of polymorphism of SLCO1B1, frequency of polymorphisms of CYP2C9*2/*3 in carriers of C allele of the gene SLCO1B1 in…”
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Impact of the CYP3A4 metabolic activity and CYP2C19 Polymorphisms on Antiplatelet effects of clopidogrel in Russian Patients with acute Coronary Syndrome undergoing coronary stent implantation by Mirzaev, K.B, Sychev, D.A, Andreev, D.A, Kazakov, R.E, Smirnov, V.V

“…Material and Methods We determined the CYP2C19 genotypes (Real-time PCR) and CYP3A4 metabolic activity (6b-hydroxycortisol/cortisol (6-OHC/FC) in urine were…”
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Pharmacogenetics of alcohol addiction: current perspectives by Zastrozhin, M S, Skryabin, V Yu, Miroshkin, S S, Bryun, E A, Sychev, D A

“…Genetics of alcohol addiction is currently a contradictive and complex field, where data in the most studies reflect methods' limitations rather than…”
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MicroRNA and vascular pathology of the eye by Moshetova, LK, Usharova, SA, Turkina, KI, Sychev, DA, Saburina, IN

“…Since the discovery of microRNAs just a few decades ago, our knowledge of these molecules and their potential as diagnostic biomarkers and therapeutic targets…”
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The influence of CYP3A5 polymorphisms on haloperidol treatment in patients with alcohol addiction by Zastrozhin, Mikhail Sergeevich, Grishina, Elena Anatolievna, Ryzhikova, Kristina Anatolievna, Smirnov, Valery Valerievich, Savchenko, Ludmila Mikhailovna, Bryun, Evgeny Alekseevich, Sychev, Dmitry Alekseevich

“…Isoenzymes CYP2D6 and CYP3A4, the activity of which varies widely, are involved in metabolism of haloperidol and may influence its profile of efficacy and…”
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Effects of CYP2D6 genetic polymorphisms on the efficacy and safety of fluvoxamine in patients with depressive disorder and comorbid alcohol use disorder by Zastrozhin, Mikhail Sergeevich, Grishina, Elena Anatolievna, Denisenko, Nataliya Petrovna, Skryabin, Valentin Yurievich, Markov, Dmitry Dmitrievich, Savchenko, Ludmila Mikhailovna, Bryun, Evgeny Alekseevich, Sychev, Dmitry Alekseevich

“…Fluvoxamine therapy is used for treatment of patients with depressive disorder, but it is often ineffective, and some patients suffer from dose-dependent…”
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The correlation between CYP2D6 isoenzyme activity and haloperidol efficacy and safety profile in patients with alcohol addiction during the exacerbation of the addiction by Sychev, Dmitry Alekseevich, Zastrozhin, Mikhail Sergeevich, Smirnov, Valery Valerieevich, Grishina, Elena Anatolievna, Savchenko, Ludmila Mikhailovna, Bryun, Evgeny Alekseevich

“…Today, it is proved that isoenzymes CYP2D6 and CYP3A4 are involved in metabolism of haloperidol. In our previous investigation, we found a medium correlation…”
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