Search Results - "Syam Krishnan, K."

Peptidomimetic Small Molecules Disrupt Type IV Secretion System Activity in Diverse Bacterial Pathogens by Shaffer, Carrie L, Good, James A D, Kumar, Santosh, Krishnan, K Syam, Gaddy, Jennifer A, Loh, John T, Chappell, Joseph, Almqvist, Fredrik, Cover, Timothy L, Hadjifrangiskou, Maria

“…Bacteria utilize complex type IV secretion systems (T4SSs) to translocate diverse effector proteins or DNA into target cells. Despite the importance of T4SSs…”
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Attenuating Listeria monocytogenes Virulence by Targeting the Regulatory Protein PrfA by Good, James A D, Andersson, Christopher, Hansen, Sabine, Wall, Jessica, Krishnan, K Syam, Begum, Afshan, Grundström, Christin, Niemiec, Moritz S, Vaitkevicius, Karolis, Chorell, Erik, Wittung-Stafshede, Pernilla, Sauer, Uwe H, Sauer-Eriksson, A Elisabeth, Almqvist, Fredrik, Johansson, Jörgen

“…The transcriptional activator PrfA, a member of the Crp/Fnr family, controls the expression of some key virulence factors necessary for infection by the human…”
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Directed diversity-oriented synthesis. Ring-fused 5- to 10-membered rings from a common peptidomimetic 2-pyridone precursor by Sellstedt, Magnus, Krishna Prasad, G., Syam Krishnan, K., Almqvist, Fredrik

“…A variety of ring-fused 2-pyridone-based central fragments were prepared using a strategy inspired by diversity-oriented synthesis. The produced compounds are…”
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Expansion of the Chlamydia trachomatis inclusion does not require bacterial replication by Engström, Patrik, Bergström, Malin, Alfaro, Astrid C, Syam Krishnan, K, Bahnan, Wael, Almqvist, Fredrik, Bergström, Sven

“…Abstract Chlamydia trachomatis replication takes place inside of a host cell, exclusively within a vacuole known as the inclusion. During an infection, the…”
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Synthetic Studies towards Pectenotoxin-2: Synthesis of the Nonanomeric 10-epi-ABCDE Ring Segment by Kinetic Spiroketalization by Aho, Jatta E., Piisola, Antti, Syam Krishnan, K., Pihko, Petri M.

“…The synthesis of the nonanomeric 10‐epi‐ABCDE ring system of pectenotoxin‐2 has been achieved by using a kinetic spiroketalization reaction. The synthesis of…”
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A 2-pyridone-amide inhibitor targets the glucose metabolism pathway of Chlamydia trachomatis by Engström, Patrik, Krishnan, K Syam, Ngyuen, Bidong D, Chorell, Erik, Normark, Johan, Silver, Jim, Bastidas, Robert J, Welch, Matthew D, Hultgren, Scott J, Wolf-Watz, Hans, Valdivia, Raphael H, Almqvist, Fredrik, Bergström, Sven

“…In a screen for compounds that inhibit infectivity of the obligate intracellular pathogen Chlamydia trachomatis, we identified the 2-pyridone amide KSK120. A…”
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Recent Advances in the Chemistry of Pentafulvenes by Preethalayam, Preethanuj, Krishnan, K. Syam, Thulasi, Sreeja, Chand, S. Sarath, Joseph, Jomy, Nair, Vijay, Jaroschik, Florian, Radhakrishnan, K. V

“…Pentafulvenes are a unique class of compounds that originally attracted attention due to their propensity to display nonbenzenoid aromaticity. Subsequently,…”
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Chemical disarming of isoniazid resistance in Mycobacterium tuberculosis by Flentie, Kelly, Harrison, Gregory A., Tükenmez, Hasan, Livny, Jonathan, Good, James A. D., Sarkar, Souvik, Zhu, Dennis X., Kinsella, Rachel L., Weiss, Leslie A., Solomon, Samantha D., Schene, Miranda E., Hansen, Mette R., Cairns, Andrew G., Kulén, Martina, Wixe, Torbjörn, Lindgren, Anders E. G., Chorell, Erik, Bengtsson, Christoffer, Krishnan, K. Syam, Hultgren, Scott J., Larsson, Christer, Almqvist, Fredrik, Stallings, Christina L.

“…Mycobacterium tuberculosis (Mtb) killed more people in 2017 than any other single infectious agent. This dangerous pathogen is able to withstand stresses…”
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Thiazolino 2‑Pyridone Amide Inhibitors of Chlamydia trachomatis Infectivity by Good, James A. D, Silver, Jim, Núñez-Otero, Carlos, Bahnan, Wael, Krishnan, K. Syam, Salin, Olli, Engström, Patrik, Svensson, Richard, Artursson, Per, Gylfe, Åsa, Bergström, Sven, Almqvist, Fredrik

“…The bacterial pathogen Chlamydia trachomatis is a global health burden currently treated with broad-spectrum antibiotics which disrupt commensal bacteria. We…”
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Thiazolino 2‑Pyridone Amide Isosteres As Inhibitors of Chlamydia trachomatis Infectivity by Good, James A. D, Kulén, Martina, Silver, Jim, Krishnan, K. Syam, Bahnan, Wael, Núñez-Otero, Carlos, Nilsson, Ingela, Wede, Emma, de Groot, Esmee, Gylfe, Åsa, Bergström, Sven, Almqvist, Fredrik

“…Chlamydia trachomatis is a global health burden due to its prevalence as a sexually transmitted disease and as the causative agent of the eye infection…”
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Synthesis of Multiring Fused 2‑Pyridones via a Nitrene Insertion Reaction: Fluorescent Modulators of α‑Synuclein Amyloid Formation by Singh, Pardeep, Chorell, Erik, Krishnan, K. Syam, Kindahl, Tomas, Åden, Jörgen, Wittung-Stafshede, Pernilla, Almqvist, Fredrik

“…An efficient, straightforward method for the synthesis of thiazolo-2-pyridone embedded peptidomimetic polyheterocycles via a catalyst-free, microwave-assisted,…”
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Access to Enantiomerically Enriched cis-2,3-Disubstituted Azetidines via Diastereoselective Hydrozirconation by Pradhan, Tarun K, Krishnan, K. Syam, Vasse, Jean-Luc, Szymoniak, Jan

“…An asymmetric variant of the hydrozirconation reaction has been established starting from Boc-protected chiral allylic amines. The resulting…”
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Synthesis of Fluorescent Ring-Fused 2‑Pyridone Peptidomimetics by Krishnan, K. Syam, Bengtsson, Christoffer, Good, James A. D, Mirkhanov, Shamil, Chorell, Erik, Johansson, Lennart B.-Å, Almqvist, Fredrik

“…Thiazolino fused 2-pyridone peptidomimetics are of significant biological importance due to their ability to interfere with adhesive fiber formation in…”
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Expeditious synthesis of N-bridged heterocycles via dipolar cycloaddition of pentafulvenes with 3-oxidopyridinium betaines by Kuthanapillil, Jinesh M., Thulasi, Sreeja, Rajan, Rani, Krishnan, K. Syam, Suresh, E., Radhakrishnan, K.V.

“…A new and highly versatile approach towards the synthesis of bicyclo[6.3.0]undecanes and bicyclo[5.3.0]decanes was accomplished. The methodology adopted…”
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[6+3] Cycloaddition of fulvenes with 3-oxidopyrylium betaine: a novel methodology for the synthesis of fused cyclooctanoid natural products by Radhakrishnan, K.V., Syam Krishnan, K., Bhadbhade, Mohan M., Bhosekar, Gaurav V.

“…Fulvenes undergo an easy [6+3] cycloaddition with 3-oxidopyrylium betaines leading to 5–8 fused oxabridged cyclooctanoids. Fulvenes undergo an easy [6+3]…”
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Studies on the synthetic utility of [6+3] cycloaddition of pentafulvenes with 3-oxidopyrylium betaines: efficient synthesis of fused ring cyclooctanoids by Krishnan, K. Syam, Smitha, Mohanlal, Suresh, E., Radhakrishnan, K.V.

“…A study on the synthetic utility of [6+3] cycloaddition of pentafulvenes with 3-oxidopyrylium betaines is described. 5–8 Fused oxa-bridged cyclooctanoids, the…”
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A Simple and Efficient Strategy Towards Eleven-Membered Carbocycles via Novel Synthetic Transformations of Pentafulvenes by Krishnan, K. Syam, Kuthanapillil, Jinesh M., Rajan, Rani, Suresh, E., Radhakrishnan, K. V.

“…A novel and versatile method towards the synthesis of eleven‐membered carbocycles through a three step reaction sequence from pentafulvenes is described. The…”
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[6+3] Cycloaddition of pentafulvenes with 3-oxidopyrylium betaine: a novel methodology toward the synthesis of 5–8 fused oxabridged cyclooctanoids by Krishnan, K. Syam, Sajisha, V.S., Anas, S., Suresh, C.H., Bhadbhade, Mohan M., Bhosekar, Gaurav V., Radhakrishnan, K.V.

“…Pentafulvenes undergo a facile [6+3] cycloaddition with 3-oxidopyrylium betaine, generated from the corresponding pyranulose acetate, leading to the formation…”
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VLSI Implementation of Reed Solomon Codes by Krishnan T., Syam, Chalil, Anu, Sreehari, K.N.

“…Reed Solomon(RS) codes are error correction codes that are widely used in communication systems. RS codes exhibits high error correction capability as compared…”
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