Search Results - "Syal, Charvi"

Promising use of metformin in treating neurological disorders: biomarker-guided therapies by Loan, Allison, Syal, Charvi, Lui, Margarita, He, Ling, Wang, Jing

“…Neurological disorders are a diverse group of conditions that affect the nervous system and include neurodegenerative diseases (Alzheimer's disease, multiple…”
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Biomarker-guided drug therapy: personalized medicine for treating Alzheimer's disease by Syal, Charvi, Wang, Jing

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Dysregulated expression of monoacylglycerol lipase is a marker for anti-diabetic drug metformin-targeted therapy to correct impaired neurogenesis and spatial memory in Alzheimer's disease by Syal, Charvi, Kosaraju, Jayasankar, Hamilton, Laura, Aumont, Anne, Chu, Alphonse, Sarma, Sailendra Nath, Thomas, Jacob, Seegobin, Matthew, Dilworth, F Jeffrey, He, Ling, Wondisford, Fredric E, Zimmermann, Robert, Parent, Martin, Fernandes, Karl, Wang, Jing

“…Monoacylglycerol lipase (Mgll), a hydrolase that breaks down the endocannabinoid 2-arachidonoyl glycerol (2-AG) to produce arachidonic acid (ARA), is a…”
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Migrating Interneurons Secrete Fractalkine to Promote Oligodendrocyte Formation in the Developing Mammalian Brain by Voronova, Anastassia, Yuzwa, Scott A., Wang, Beatrix S., Zahr, Siraj, Syal, Charvi, Wang, Jing, Kaplan, David R., Miller, Freda D.

“…During development, newborn interneurons migrate throughout the embryonic brain. Here, we provide evidence that these interneurons act in a paracrine fashion…”
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Metformin promotes CNS remyelination and improves social interaction following focal demyelination through CBP Ser436 phosphorylation by Kosaraju, Jayasankar, Seegobin, Matthew, Gouveia, Ayden, Syal, Charvi, Sarma, Sailendra Nath, Lu, Kevin Jiaqi, Ilin, Julius, He, Ling, Wondisford, Fredric E., Lagace, Diane, De Repentigny, Yves, Kothary, Rashmi, Wang, Jing

“…Individuals with demyelinating diseases often experience difficulties during social interactions that are not well studied in preclinical models. Here, we…”
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Single-cell profiling of brain pericyte heterogeneity following ischemic stroke unveils distinct pericyte subtype-targeted neural reprogramming potential and its underlying mechanisms by Loan, Allison, Awaja, Nidaa, Lui, Margarita, Syal, Charvi, Sun, Yiren, Sarma, Sailendra N, Chona, Ragav, Johnston, William B, Cordova, Alex, Saraf, Devansh, Nakhlé, Anabella, O'Connor, Kaela, Thomas, Jacob, Leung, Joseph, Seegobin, Matthew, He, Ling, Wondisford, Fredric E, Picketts, David J, Tsai, Eve C, Chan, Hing Man, Wang, Jing

“…Brain pericytes can acquire multipotency to produce multi-lineage cells following injury. However, pericytes are a heterogenous population and it remains…”
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Ectopic expression of aPKC-mediated phosphorylation in p300 modulates hippocampal neurogenesis, CREB binding and fear memory differently with age by Syal, Charvi, Seegobin, Matthew, Sarma, Sailendra Nath, Gouveia, Ayden, Hsu, Karolynn, Niibori, Yosuke, He, Ling, Wondisford, Fredric E., Frankland, Paul W., Wang, Jing

“…Epigenetic modifications have become an emerging interface that links extrinsic signals to alterations of gene expression that determine cell identity and…”
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