Search Results - "Syahirah, Ramizah"

CAR-neutrophil mediated delivery of tumor-microenvironment responsive nanodrugs for glioblastoma chemo-immunotherapy by Chang, Yun, Cai, Xuechao, Syahirah, Ramizah, Yao, Yuxing, Xu, Yang, Jin, Gyuhyung, Bhute, Vijesh J., Torregrosa-Allen, Sandra, Elzey, Bennett D., Won, You-Yeon, Deng, Qing, Lian, Xiaojun Lance, Wang, Xiaoguang, Eniola-Adefeso, Omolola, Bao, Xiaoping

“…Glioblastoma (GBM) is one of the most aggressive and lethal solid tumors in human. While efficacious therapeutics, such as emerging chimeric antigen receptor…”
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Phenotypical microRNA screen reveals a noncanonical role of CDK2 in regulating neutrophil migration by Hsu, Alan Y., Wang, Decheng, Liu, Sheng, Lu, Justice, Syahirah, Ramizah, Bennin, David A., Huttenlocher, Anna, Umulis, David M., Wan, Jun, Deng, Qing

“…Neutrophil migration is essential for inflammatory responses to kill pathogens; however, excessive neutrophilic inflammation also leads to tissue injury and…”
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Rora Regulates Neutrophil Migration and Activation in Zebrafish by Hsu, Alan Y, Wang, Tianqi, Syahirah, Ramizah, Liu, Sheng, Li, Kailing, Zhang, Weiwei, Wang, Jiao, Cao, Ziming, Tian, Simon, Matosevic, Sandro, Staiger, Christopher J, Wan, Jun, Deng, Qing

“…Neutrophil migration and activation are essential for defense against pathogens. However, this process may also lead to collateral tissue injury. We used…”
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A curious case of cyclin‐dependent kinases in neutrophils by Syahirah, Ramizah, Hsu, Alan Y., Deng, Qing

“…Neutrophils are terminally differentiated, short‐lived white blood cells critical for innate immunity. Although cyclin‐dependent kinases (CDKs) are typically…”
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Engineering chimeric antigen receptor neutrophils from human pluripotent stem cells for targeted cancer immunotherapy by Chang, Yun, Syahirah, Ramizah, Wang, Xuepeng, Jin, Gyuhyung, Torregrosa-Allen, Sandra, Elzey, Bennett D., Hummel, Sydney N., Wang, Tianqi, Li, Can, Lian, Xiaojun, Deng, Qing, Broxmeyer, Hal E., Bao, Xiaoping

“…Neutrophils, the most abundant white blood cells in circulation, are closely related to cancer development and progression. Healthy primary neutrophils present…”
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Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ by Chen, Chun-Liang, Syahirah, Ramizah, Ravala, Sandeep K., Yen, Yu-Chen, Klose, Thomas, Deng, Qing, Tesmer, John J. G.

“…The conversion of phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 3,4,5-triphosphate by phosphoinositide 3-kinase γ (PI3Kγ) is critical for…”
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Method for Visualization of Emergency Granulopoiesis in the Zebrafish Embryo by Syahirah, Ramizah, Beckman, Jennifer, Malik, Hanna, Hsu, Alan Y, Deng, Qing

“…Emergency granulopoiesis (EG) is a response to severe inflammation in which increased neutrophils are generated in the hematopoietic tissue. Photolabeling is…”
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Inducible overexpression of zebrafish microRNA-722 suppresses chemotaxis of human neutrophil like cells by Hsu, Alan Y., Liu, Sheng, Syahirah, Ramizah, Brasseale, Kent A., Wan, Jun, Deng, Qing

“…•Inducible co-expression of a protein coding gene and a microRNA in HL-60 cells.•dre-miR-722 over-expression suppresses signaling in differentiated HL-60…”
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Mitofusin 2 regulates neutrophil adhesive migration and the actin cytoskeleton by Zhou, Wenqing, Hsu, Alan Y, Wang, Yueyang, Syahirah, Ramizah, Wang, Tianqi, Jeffries, Jacob, Wang, Xu, Mohammad, Haroon, Seleem, Mohamed N, Umulis, David, Deng, Qing

“…Neutrophils rely on glycolysis for energy production. How mitochondria regulate neutrophil function is not fully understood. Here, we report that mitochondrial…”
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A robust and flexible CRISPR/Cas9-based system for neutrophil-specific gene inactivation in zebrafish by Wang, Yueyang, Hsu, Alan Y, Walton, Eric M, Park, Sung Jun, Syahirah, Ramizah, Wang, Tianqi, Zhou, Wenqing, Ding, Chang, Lemke, Abby Pei, Zhang, GuangJun, Tobin, David M, Deng, Qing

“…CRISPR/Cas9-based tissue-specific knockout techniques are essential for probing the functions of genes in embryonic development and disease using zebrafish…”
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Chemically-defined generation of human hemogenic endothelium and definitive hematopoietic progenitor cells by Chang, Yun, Syahirah, Ramizah, Oprescu, Stephanie N., Wang, Xuepeng, Jung, Juhyung, Cooper, Scott H., Torregrosa-Allen, Sandra, Elzey, Bennett D., Hsu, Alan Y., Randolph, Lauren N., Sun, Yufei, Kuang, Shihuan, Broxmeyer, Hal E., Deng, Qing, Lian, Xiaojun, Bao, Xiaoping

“…Human hematopoietic stem cells (HSCs), which arise from aorta-gonad-mesonephros (AGM), are widely used to treat blood diseases and cancers. However, a…”
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Engineered anti-prostate cancer CAR-neutrophils from human pluripotent stem cells by Harris, Jackson D., Chang, Yun, Syahirah, Ramizah, Lian, Xiaojun Lance, Deng, Qing, Bao, Xiaoping

“…Immunotherapy is a powerful technique where immune cells are modified to improve cytotoxicity against cancerous cells to treat cancers that do not respond to…”
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Mitofusin 2 regulates neutrophil adhesive migration and the actin cytoskeleton by Zhou, Wenqing, Hsu, Alan Y, Wang, Yueyang, Syahirah, Ramizah, Wang, Tianqi, Jeffries, Jacob, Wang, Xu, Mohammad, Haroon, Seleem, Mohamed N, Umulis, David, Deng, Qing

“…Neutrophils rely on glycolysis for energy production. How mitochondria regulate neutrophil function is not fully understood. Here, we report that mitochondrial…”
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