Search Results - "Swinney, Katie"

ABHD6 Blockade Exerts Antiepileptic Activity in PTZ-Induced Seizures and in Spontaneous Seizures in R6/2 Mice by Naydenov, Alipi V., Horne, Eric A., Cheah, Christine S., Swinney, Katie, Hsu, Ku-Lung, Cao, Jessica K., Marrs, William R., Blankman, Jacqueline L., Tu, Sarah, Cherry, Allison E., Fung, Susan, Wen, Andy, Li, Weiwei, Saporito, Michael S., Selley, Dana E., Cravatt, Benjamin F., Oakley, John C., Stella, Nephi

“…The serine hydrolase α/β-hydrolase domain 6 (ABHD6) hydrolyzes the most abundant endocannabinoid (eCB) in the brain, 2-arachidonoylglycerol (2-AG), and…”
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Genetic rescue of CB1 receptors on medium spiny neurons prevents loss of excitatory striatal synapses but not motor impairment in HD mice by Naydenov, Alipi V, Sepers, Marja D, Swinney, Katie, Raymond, Lynn A, Palmiter, Richard D, Stella, Nephi

“…Abstract Huntington's disease (HD) is caused by an expanded polyglutamine repeat in huntingtin protein that disrupts synaptic function in specific neuronal…”
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Gravin Is a Transitory Effector of Polo-like Kinase 1 during Cell Division by Canton, David A., Keene, C. Dirk, Swinney, Katie, Langeberg, Lorene K., Nguyen, Vivian, Pelletier, Laurence, Pawson, Tony, Wordeman, Linda, Stella, Nephi, Scott, John D.

“…The mitogenic and second-messenger signals that promote cell proliferation often proceed through multienzyme complexes. The kinase-anchoring protein Gravin…”
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ST-11: A New Brain-Penetrant Microtubule-Destabilizing Agent with Therapeutic Potential for Glioblastoma Multiforme by Cherry, Allison E, Haas, Brian R, Naydenov, Alipi V, Fung, Susan, Xu, Cong, Swinney, Katie, Wagenbach, Michael, Freeling, Jennifer, Canton, David A, Coy, Jonathan, Horne, Eric A, Rickman, Barry, Vicente, Juan Jesus, Scott, John D, Ho, Rodney J Y, Liggitt, Denny, Wordeman, Linda, Stella, Nephi

“…Glioblastoma multiforme is a devastating and intractable type of cancer. Current antineoplastic drugs do not improve the median survival of patients diagnosed…”
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Downregulation of cannabinoid receptor 1 from neuropeptide Y interneurons in the basal ganglia of patients with Huntington's disease and mouse models by Horne, Eric A., Coy, Jonathan, Swinney, Katie, Fung, Susan, Cherry, Allison E. T., Marrs, William R., Naydenov, Alipi V., Lin, Yi Hsing, Sun, Xiaocui, Dirk Keene, C., Grouzmann, Eric, Muchowski, Paul, Bates, Gillian P., Mackie, Ken, Stella, Nephi

“…Cannabinoid receptor 1 (CB1 receptor) controls several neuronal functions, including neurotransmitter release, synaptic plasticity, gene expression and…”
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ATPS-06BRAIN-PENETRANT ALKYLINDOLE COMPOUNDS PROMOTE APOPTOSIS IN GLIOMA CELLS THROUGH MICROTUBULE DESTABILIZATION by Cherry, Allison, Haas, Brian, Naydenov, Alipi, Fung, Susan, Xu, Cong, Swinney, Katie, Wagenbach, Michael, Freeling, Jennifer, Canton, David, Coy, Jonathan, Horne, Eric, Rickman, Barry, Scott, John, Ho, Rodney, Liggitt, Denny, Wordeman, Linda, Stella, Nephi

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