Search Results - "Swindell, A. C."

Guidance in the setting of drug particle size specifications to minimize variability in absorption by JOHNSON, K. C, SWINDELL, A. C

“…To provide guidance in setting particle size specifications for poorly soluble drugs to minimize variability in absorption. A previously reported computer…”
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An analysis of 14 molecular markers for monitoring osteoarthritis: segregation of the markers into clusters and distinguishing osteoarthritis at baseline by Otterness, I.G, Swindell, A.C, Zimmerer, R.O, Poole, A.R, Ionescu, M, Weiner, E

“…Objective To investigate the relationships between serum and urinary molecular markers (MM) used to monitor osteoarthritis. Design Forty osteoarthritis…”
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An analysis of 14 molecular markers for monitoring osteoarthritis. Relationship of the markers to clinical end-points by Otterness, I.G., Weiner, E., Swindell, A.C., Zimmerer, R.O., Ionescu, M., Poole, A.R.

“…Objective To investigate whether any of 14 serum and urine molecular markers (MMs) used to monitor osteoarthritis (OA) would be associated with particular…”
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Criteria for selection and application of molecular markers for clinical studies of osteoarthritis by Otterness, I.G., Swindell, A.C.

“…Objective: To develop criteria for the selection and application of molecular markers for the study of osteoarthritis (OA). Methods: Statistical criteria for…”
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Analysis of changes in acute-phase plasma proteins in an acute inflammatory response and in rheumatoid arthritis using two-dimensional gel electrophoresis by Doherty, N S, Littman, B H, Reilly, K, Swindell, A C, Buss, J M, Anderson, N L

“…Two-dimensional (2-D) gel analysis was used to examine differences in the levels of 19 plasma proteins: before and after an acute inflammatory reaction…”
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Influence of immunosuppression on the pharmacokinetics and pharmacodynamics of azithromycin in infected mouse tissues by Girard, D., Regan, P. A., Milisen, W. B., Retsema, J. A., Swindell, A. C.

“…Azithromycin has been shown to preferentially distribute to infection loci. Due to the potential contribution of phagocytes as transporters of drug to these…”
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Leukotriene D4 receptor antagonism reduces airway hyperresponsiveness in monkeys by Turner, C R, Smith, W B, Andresen, C J, Swindell, A C, Watson, J W

“…Airway hyperresponsiveness (AHR) and pulmonary inflammation are observations that are consistently associated with asthma and also occur in a…”
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Spiro hydantoin aldose reductase inhibitors derived from 8-aza-4-chromanones by Sarges, Reinhard, Goldstein, Steven W, Welch, Willard M, Swindell, Archie C, Siegel, Todd W, Beyer, Thomas A

“…A series of spiro hydantoins derived from 8-azachromanones (2,3-dihydro-4H-pyrano[2,3-b]pyridin-4-ones) has been prepared and tested for aldose reductase…”
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Effects of doxazosin on atherosclerosis in cholesterol-fed rabbits by Swindell, A C, Krupp, M N, Twomey, T M, Reynolds, J A, Chichester, C O

“…Doxazosin was administered to rabbits fed diets enriched in cholesterol and peanut oil for 7.5 or 12 weeks, in 2 separate experiments. Doxazosin suppressed the…”
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Purification and Properties of a Palmityl Thioesterase II from Escherichia coli by Barnes, Jr, E M, Wakil, S J, Swindell, A C

“…A palmityl thioesterase II which is insensitive to inhibition by diisopropyl fluorophosphate has been purified 20-fold from extracts of Escherichia coli . This…”
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Investigation of the Component Reactions of Oxidative Sterol Demethylation by Swindell, A C, Gaylor, J L

“…The participation of 3-ketosteroids in the biosynthesis of cholesterol was investigated with preparations of rat liver microsomes. Without exogenous NADPH,…”
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Intermediate- and long-chain beta-hydroxyacyl-ACP dehydrases from E. coli fatty acid synthetase by Mizugaki, M, Swindell, A C, Wakil, S J

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The disposition of doxycycline by the rat by Schach VON WITTENAU, M, Schachaavonwittenau, M, Twomey, T M, Swindell, A C

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Synergistic effect on reduction in blood pressure with coadministration of the renin inhibitor, CP-80,794, and the angiotensin converting enzyme inhibitor, captopril by Fossa, A A, Weinberg, L J, Barber, R L, Rauch, A L, Nocerini, M R, Murphy, W R, Swindell, A C

“…The effects of coadministration of a renin inhibitor, CP-80,794, and an angiotensin converting enzyme inhibitor, captopril, on blood pressure of…”
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Effects of alpha 1-inhibition on lipid metabolism in the rat by Woodside, W F, Swindell, A C

“…Prazosin or doxazosin, selective alpha 1-adrenergic receptor inhibitors used in the treatment of hypertension, are known from clinical studies to lower plasma…”
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Effects of doxazosin on diet-induced hypercholesterolemia in C57BR/cdJ mice by Swindell, Archie C., Valentine, James J.

“…Plasma cholesterol levels are markedly reduced when doxazosin, a selective α 1-adrenoceptor inhibitor, is administered for several days to C57BR/cdJ mice that…”
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Investigation of the component reactions of oxidative sterol demethylation. Formation and metabolism of 3-ketosteroid intermediates by Swindell, A C, Gaylor, J L

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Interactions of doxazosin with insulin or glucagon in the ob/ob mouse by Swindell, A C, Valentine, J J

“…Doxazosin, a selective inhibitor of alpha 1-adrenergic receptors, when administered alone or in combination with insulin or glucagon to mature ob/ob mice,…”
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Influence of immunosuppression on the pharmacokinetics and pharmacodynamics of azithromycin in infected mouse tissues: Azithromycin: further clinical experience by GIRARD, D, REGAN, P. A, MILISEN, W. B, RETSEMA, J. A, SWINDELL, A. C

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Influence of immunosuppression on the pharmacokinetics and pharmacodynamics of azithromycin in infected mouse tissues by Girard, D, Regan, P A, Milisen, W B, Retsema, JA, Swindell, A C

“…Azithromycin has been shown to preferentially distribute to infection loci. Due to the potential contribution of phagocytes as transporters of drug to these…”
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