Search Results - "Swigart, Philip M."

An Alpha-1A Adrenergic Receptor Agonist Prevents Acute Doxorubicin Cardiomyopathy in Male Mice by Montgomery, Megan D, Chan, Trevor, Swigart, Philip M, Myagmar, Bat-Erdene, Dash, Rajesh, Simpson, Paul C

“…Alpha-1 adrenergic receptors mediate adaptive effects in the heart and cardiac myocytes, and a myocyte survival pathway involving the alpha-1A receptor subtype…”
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The α1A-adrenergic receptor subtype mediates increased contraction of failing right ventricular myocardium by Cowley, Patrick M, Wang, Guanying, Chang, Audrey N, Makwana, Om, Swigart, Philip M, Lovett, David H, Stull, James T, Simpson, Paul C, Baker, Anthony J

“…Dysfunction of the right ventricle (RV) is closely related to prognosis for patients with RV failure. Therefore, strategies to improve failing RV function are…”
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The Alpha-1A Adrenergic Receptor in the Rabbit Heart by Thomas, Jr, R Croft, Cowley, Patrick M, Singh, Abhishek, Myagmar, Bat-Erdene, Swigart, Philip M, Baker, Anthony J, Simpson, Paul C

“…The alpha-1A-adrenergic receptor (AR) subtype is associated with cardioprotective signaling in the mouse and human heart. The rabbit is useful for cardiac…”
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The Alpha-1D Is the Predominant Alpha-1-Adrenergic Receptor Subtype in Human Epicardial Coronary Arteries by Jensen, Brian C., MD, Swigart, Philip M., MS, Laden, Marie-Eve, MD, DeMarco, Teresa, MD, Hoopes, Charles, MD, Simpson, Paul C., MD

“…Objectives The goal was to identify alpha-1-adrenergic receptor (AR) subtypes in human coronary arteries. Background The α1-ARs regulate human coronary blood…”
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Distinctive ERK and p38 signaling in remote and infarcted myocardium during post-MI remodeling in the mouse by Yeh, Che-Chung, Li, Hongzhe, Malhotra, Deepak, Turcato, Sally, Nicholas, Susan, Tu, Richard, Zhu, Bo-Qing, Cha, John, Swigart, Philip M, Myagmar, Bat-Erdene, Baker, Anthony J., Simpson, Paul C., Mann, Michael J.

“…Global activation of MAP kinases has been reported in both human and experimental heart failure. Chronic remodeling of the surviving ventricular wall after…”
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A Myocardial Slice Culture Model Reveals Alpha-1A-Adrenergic Receptor Signaling in the Human Heart by Thomas, R. Croft, MD, Singh, Abhishek, MD, PhD, Cowley, Patrick M., PhD, Myagmar, Bat-Erdene, MD, PhD, Montgomery, Megan D., PhD, Swigart, Philip M., BS, De Marco, Teresa, MD, Baker, Anthony J., PhD, Simpson, Paul C., MD

“…Summary The authors used 52 nonfailing and failing human hearts to develop a simple, high throughput left ventricular myocardial slice model that is stable by…”
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Adrenergic Receptors in Individual Ventricular Myocytes: The Beta-1 and Alpha-1B Are in All Cells, the Alpha-1A Is in a Subpopulation, and the Beta-2 and Beta-3 Are Mostly Absent by Myagmar, Bat-Erdene, Flynn, James M, Cowley, Patrick M, Swigart, Philip M, Montgomery, Megan D, Thai, Kevin, Nair, Divya, Gupta, Rumita, Deng, David X, Hosoda, Chihiro, Melov, Simon, Baker, Anthony J, Simpson, Paul C

“…RATIONALE:It is unknown whether every ventricular myocyte expresses all 5 of the cardiac adrenergic receptors (ARs), β1, β2, β3, α1A, and α1B. The β1 and β2…”
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Ten commercial antibodies for alpha-1-adrenergic receptor subtypes are nonspecific by Jensen, Brian C., Swigart, Philip M., Simpson, Paul C.

“…Commercial antibodies are used widely to quantify and localize the α1-adrenergic receptor (AR) subtypes, α1A, α1B, and α1D. We tested ten antibodies, from…”
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Reversal of right ventricular failure by chronic α 1A -subtype adrenergic agonist therapy by Cowley, Patrick M, Wang, Guanying, Swigart, Philip M, Raghunathan, Anaha, Reddy, Nikitha, Dulam, Pranavi, Lovett, David H, Simpson, Paul C, Baker, Anthony J

“…Right ventricular (RV) failure (RVF) is a serious disease with no effective treatment available. We recently reported a disease prevention study showing that…”
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Coupling to Gq Signaling Is Required for Cardioprotection by an Alpha-1A-Adrenergic Receptor Agonist by Myagmar, Bat-Erdene, Ismaili, Taylor, Swigart, Philip M, Raghunathan, Anaha, Baker, Anthony J, Sahdeo, Sunil, Blevitt, Jonathan M, Milla, Marcos E, Simpson, Paul C

“…RATIONALE:Gq signaling in cardiac myocytes is classically considered toxic. Targeting Gq directly to test this is problematic, because cardiac myocytes have…”
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Response by Simpson et al to Letter Regarding Article, “Adrenergic Receptors in Individual Ventricular Myocytes: the Beta-1 and Alpha-1B Are in All Cells, the Alpha-1A Is in a Subpopulation, and the Beta-2 and Beta-3 Are Mostly Absent” by Simpson, Paul C, Myagmar, Bat-Erdene, Swigart, Philip M, Melov, Simon, Baker, Anthony J

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β-Myosin Heavy Chain Is Induced by Pressure Overload in a Minor Subpopulation of Smaller Mouse Cardiac Myocytes by López, Javier E, Myagmar, Bat-Erdene, Swigart, Philip M, Montgomery, Megan D, Haynam, Stephen, Bigos, Marty, Rodrigo, Manoj C, Simpson, Paul C

“…RATIONALE:Induction of the fetal hypertrophic marker gene β-myosin heavy chain (β-MyHC) is a signature feature of pressure overload hypertrophy in rodents…”
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Novel large-particle FACS purification of adult ventricular myocytes reveals accumulation of myosin and actin disproportionate to cell size and proteome in normal post-weaning development by López, Javier E., Sharma, Janhavi, Avila, Jorge, Wood, Taylor S., VanDyke, Jonathan E., McLaughlin, Bridget, Abbey, Craig K., Wong, Andrew, Myagmar, Bat-Erdene, Swigart, Philip M., Simpson, Paul C., Chiamvimonvat, Nipavan

“…Quantifying cellular proteins in ventricular myocytes (MCs) is challenging due to tissue heterogeneity and the variety of cell sizes in the heart. In…”
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α1-Adrenergic Receptor Subtypes in Nonfailing and Failing Human Myocardium by Jensen, Brian C., Swigart, Philip M., De Marco, Teresa, Hoopes, Charles, Simpson, Paul C.

“…Background— α1-adrenergic receptors (α1-ARs) play adaptive roles in the heart and protect against the development of heart failure. The 3 α1-AR subtypes, α1A,…”
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Cardiomyocyte Alpha-1A Adrenergic Receptors Mitigate Postinfarct Remodeling and Mortality by Constraining Necroptosis by Zhang, Jiandong, Sandroni, Peyton B, Huang, Wei, Gao, Xiaohua, Oswalt, Leah, Schroder, Melissa A, Lee, SungHo, Shih, Yen-Yu I, Huang, Hsiao-Ying S, Swigart, Philip M, Myagmar, Bat E, Simpson, Paul C, Rossi, Joseph S, Schisler, Jonathan C, Jensen, Brian C

“…Clinical studies have shown that α1-adrenergic receptor antagonists (α-blockers) are associated with increased heart failure risk. The mechanism underlying…”
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The α1A/C- and α1B-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse by O’Connell, Timothy D., Ishizaka, Shinji, Nakamura, Akihiro, Swigart, Philip M., Rodrigo, M.C., Simpson, Gregory L., Cotecchia, Susanna, Rokosh, D. Gregg, Grossman, William, Foster, Elyse, Simpson, Paul C.

“…Catecholamines and α 1 -adrenergic receptors (α 1 -ARs) cause cardiac hypertrophy in cultured myocytes and transgenic mice, but heart size is normal in single…”
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Functional alpha-1B adrenergic receptors on human epicardial coronary artery endothelial cells by Jensen, Brian C., Swigart, Philip M., Montgomery, Megan D., Simpson, Paul C.

“…Alpha-1-adrenergic receptors (α1-ARs) regulate coronary arterial blood flow by binding catecholamines, norepinephrine (NE), and epinephrine (EPI), causing…”
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Cardiac transgenic matrix metalloproteinase-2 expression directly induces impaired contractility by WANG, Guan-Ying, BERGMAN, Marina R, NGUYEN, Anita P, TURCATO, Sally, SWIGART, Philip M, RODRIGO, Manoj C, SIMPSON, Paul C, KARLINER, Joel S, LOVER, David H, BAKER, Anthony J

“…Matrix metalloproteinase-2 (MMP-2) plays a major role in dysfunctional ventricular remodeling following myocardial injury induced by ischemia/reperfusion and…”
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Structure-Function Analysis of Phosphatidylinositol Transfer Protein Alpha Bound to Human Phosphatidylinositol by Tilley, Sarah J., Skippen, Alison, Murray-Rust, Judith, Swigart, Philip M., Stewart, Albert, Morgan, Clive P., Cockcroft, Shamshad, McDonald, Neil Q.

“…Phosphatidylinositol transfer protein α (PITPα) selectively transports and promotes exchange of phosphatidylinositol (PI) and phosphatidylcholine (PC) between…”
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Cardiac transgenesis with the tetracycline transactivator changes myocardial function and gene expression by McCloskey, Diana T, Turnbull, Lynne, Swigart, Philip M, Zambon, Alexander C, Turcato, Sally, Joho, Shuji, Grossman, William, Conklin, Bruce R, Simpson, Paul C, Baker, Anthony J

“…1 Department of Radiology, University of California, San Francisco 2 Department of Medicine, University of California, San Francisco 3 Department of…”
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