Search Results - "Swift, Amy"

Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells by Wu, Min, Neilson, Andy, Swift, Amy L, Moran, Rebecca, Tamagnine, James, Parslow, Diane, Armistead, Suzanne, Lemire, Kristie, Orrell, Jim, Teich, Jay, Chomicz, Steve, Ferrick, David A

“…Increased conversion of glucose to lactic acid associated with decreased mitochondrial respiration is a unique feature of tumors first described by Otto…”
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Integrative analysis of gene expression, DNA methylation, physiological traits, and genetic variation in human skeletal muscle by Taylor, D. Leland, Jackson, Anne U., Narisu, Narisu, Hemani, Gibran, Erdos, Michael R., Chines, Peter S., Swift, Amy, Idol, Jackie, Didion, John P., Welch, Ryan P., Kinnunen, Leena, Saramies, Jouko, Lakka, Timo A., Laakso, Markku, Tuomilehto, Jaakko, Parker, Stephen C. J., Koistinen, Heikki A., Smith, George Davey, Boehnke, Michael, Scott, Laura J., Birney, Ewan, Collins, Francis S.

“…We integrate comeasured gene expression and DNA methylation (DNAme) in 265 human skeletal muscle biopsies from the FUSION study with >7 million genetic…”
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Genome-Wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility Variants by Scott, Laura J, Mohlke, Karen L, Bonnycastle, Lori L, Willer, Cristen J, Li, Yun, Duren, William L, Erdos, Michael R, Stringham, Heather M, Chines, Peter S, Jackson, Anne U, Prokunina-Olsson, Ludmila, Ding, Chia-Jen, Swift, Amy J, Narisu, Narisu, Hu, Tianle, Pruim, Randall, Xiao, Rui, Li, Xiao-Yi, Conneely, Karen N, Riebow, Nancy L, Sprau, Andrew G, Tong, Maurine, White, Peggy P, Hetrick, Kurt N, Barnhart, Michael W, Bark, Craig W, Goldstein, Janet L, Watkins, Lee, Xiang, Fang, Saramies, Jouko, Buchanan, Thomas A, Watanabe, Richard M, Valle, Timo T, Kinnunen, Leena, Abecasis, Gonçalo R, Pugh, Elizabeth W, Doheny, Kimberly F, Bergman, Richard N, Tuomilehto, Jaakko, Collins, Francis S, Boehnke, Michael

“…Identifying the genetic variants that increase the risk of type 2 diabetes (T2D) in humans has been a formidable challenge. Adopting a genome-wide association…”
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Systematic comparison of three genomic enrichment methods for massively parallel DNA sequencing by Teer, Jamie K, Bonnycastle, Lori L, Chines, Peter S, Hansen, Nancy F, Aoyama, Natsuyo, Swift, Amy J, Abaan, Hatice Ozel, Albert, Thomas J, Margulies, Elliott H, Green, Eric D, Collins, Francis S, Mullikin, James C, Biesecker, Leslie G

“…Massively parallel DNA sequencing technologies have greatly increased our ability to generate large amounts of sequencing data at a rapid pace. Several methods…”
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Autosomal Dominant Diabetes Arising From a Wolfram Syndrome 1 Mutation by BONNYCASTLE, Lori L, CHINES, Peter S, NARISU, Narisu, GOLDFEDER, Rachel L, STITZEL, Michael L, SIMIN LU, BOEHNKE, Michael, URANO, Fumihiko, COLLINS, Francis S, LAAKSO, Markku, HARA, Takashi, HUYGHE, Jeroen R, SWIFT, Amy J, HEIKINHEIMO, Pirkko, MAHADEVAN, Jana, PELTONEN, Sirkku, HUOPIO, Hanna, NUUTILA, Pirjo

“…We used an unbiased genome-wide approach to identify exonic variants segregating with diabetes in a multigenerational Finnish family. At least eight members of…”
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Human pancreatic islet microRNAs implicated in diabetes and related traits by large-scale genetic analysis by Taylor, Henry J, Hung, Yu-Han, Narisu, Narisu, Erdos, Michael R, Kanke, Matthew, Yan, Tingfen, Grenko, Caleb M, Swift, Amy J, Bonnycastle, Lori L, Sethupathy, Praveen, Collins, Francis S, Taylor, D Leland

“…Genetic studies have identified ≥240 loci associated with the risk of type 2 diabetes (T2D), yet most of these loci lie in non-coding regions, masking the…”
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Functional interrogation of twenty type 2 diabetes-associated genes using isogenic human embryonic stem cell-derived β-like cells by Xue, Dongxiang, Narisu, Narisu, Taylor, D Leland, Zhang, Meili, Grenko, Caleb, Taylor, Henry J, Yan, Tingfen, Tang, Xuming, Sinha, Neelam, Zhu, Jiajun, Vandana, J Jeya, Nok Chong, Angie Chi, Lee, Angela, Mansell, Erin C, Swift, Amy J, Erdos, Michael R, Zhong, Aaron, Bonnycastle, Lori L, Zhou, Ting, Chen, Shuibing, Collins, Francis S

“…Genetic studies have identified numerous loci associated with type 2 diabetes (T2D), but the functional roles of many loci remain unexplored. Here, we…”
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Hydroa vacciniforme–like lymphoproliferative disorder: an EBV disease with a low risk of systemic illness in whites by Cohen, Jeffrey I., Manoli, Irini, Dowdell, Kennichi, Krogmann, Tammy A., Tamura, Deborah, Radecki, Pierce, Bu, Wei, Turk, Siu-Ping, Liepshutz, Kelly, Hornung, Ronald L., Fassihi, Hiva, Sarkany, Robert P., Bonnycastle, Lori L., Chines, Peter S., Swift, Amy J., Myers, Timothy G., Levoska, Melissa A., DiGiovanna, John J., Collins, Francis S., Kraemer, Kenneth H., Pittaluga, Stefania, Jaffe, Elaine S.

“…Patients with classic hydroa vacciniforme–like lymphoproliferative disorder (HVLPD) typically have high levels of Epstein-Barr virus (EBV) DNA in T cells…”
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Modeling islet enhancers using deep learning identifies candidate causal variants at loci associated with T2D and glycemic traits by Hudaiberdiev, Sanjarbek, Taylor, D Leland, Song, Wei, Narisu, Narisu, Bhuiyan, Redwan M, Taylor, Henry J, Tang, Xuming, Yan, Tingfen, Swift, Amy J, Bonnycastle, Lori L, Consortium, Diamante, Chen, Shuibing, Stitzel, Michael L, Erdos, Michael R, Ovcharenko, Ivan, Collins, Francis S

“…Genetic association studies have identified hundreds of independent signals associated with type 2 diabetes (T2D) and related traits. Despite these successes,…”
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Single-cell transcriptomic profiling of human pancreatic islets reveals genes responsive to glucose exposure over 24 h by Grenko, Caleb M., Taylor, Henry J., Bonnycastle, Lori L., Xue, Dongxiang, Lee, Brian N., Weiss, Zoe, Yan, Tingfen, Swift, Amy J., Mansell, Erin C., Lee, Angela, Robertson, Catherine C., Narisu, Narisu, Erdos, Michael R., Chen, Shuibing, Collins, Francis S., Taylor, D. Leland

“…Aims/hypothesis Disruption of pancreatic islet function and glucose homeostasis can lead to the development of sustained hyperglycaemia, beta cell…”
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Common variants at 30 loci contribute to polygenic dyslipidemia by Kooner, Jaspal S, Mohlke, Karen L, Groop, Leif, Schadt, Eric E, O'Donnell, Christopher J, Zelenika, Diana, Sanna, Serena, Bonnycastle, Lori L, Yang, Qiong, Hercberg, Serge, Schlessinger, David, Chambers, John C, Laakso, Markku, Li, Yun, Ordovas, Jose M, Ferrucci, Luigi, Orho-Melander, Marju, Surti, Aarti, de Bakker, Paul I W, Clarke, Robert, Kathiresan, Sekar, Tanaka, Toshiko, Stringham, Heather M, Salomaa, Veikko, Willer, Cristen J, Scott, Laura J, Tuomilehto, Jaakko, Swift, Amy J, Lathrop, G Mark, Melander, Olle, Collins, Rory, Dupuis, Josée, Collins, Francis S, Lunetta, Kathryn L, Jackson, Anne U, Galan, Pilar, Peltonen, Leena, Peloso, Gina M, Musunuru, Kiran, Kuusisto, Johanna, Sundvall, Jouko, Crawford, Gabriel, Guiducci, Candace, Meneton, Pierre, Lakatta, Edward G, Altshuler, David, Scheet, Paul, Burtt, Noel P, Kaplan, Lee, Abecasis, Gonçalo R, Parish, Sarah, Uda, Manuela, Kubalanza, Kari A, Scuteri, Angelo, Boehnke, Michael, Voight, Benjamin F, Cupples, L Adrienne, Demissie, Serkalem, Bennett, Derrick, Bergman, Richard N, Morken, Mario A

“…Sekar Kathiresan et al . report genome-wide association studies for polygenic dyslipidemia. From a meta-analysis of seven genome-wide association studies and…”
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Newly identified loci that influence lipid concentrations and risk of coronary artery disease by Narisu, Narisu, Lakatta, Edward, Mohlke, Karen L, Willer, Cristen J, Shuldiner, Alan R, Najjar, Samer S, Davey-Smith, George, Scuteri, Angelo, Zelenika, Diana, Li, Yun, Galan, Pilar, Shen, Haiqing, Schlessinger, David, Lawlor, Debbie A, Collins, Francis S, Strait, James, Meneton, Pierre, Duren, William L, Clarke, Robert, Watanabe, Richard M, Ebrahim, Shah, Mulas, Antonella, Uda, Manuela, Swift, Amy J, Albai, Giuseppe, Bergman, Richard N, Maschio, Andrea, Collins, Rory, Tuomilehto, Jaakko, Scott, Laura J, Bonnycastle, Lori L, Hercberg, Serge, Busonero, Fabio, Boehnke, Michael, Nagaraja, Ramaiah, Jackson, Anne U, Ben-Shlomo, Yoav, Morken, Mario A, Heath, Simon C, Stringham, Heather M, Abecasis, Gonçalo R, Cao, Antonio, Scheet, Paul A, Lathrop, G Mark, Parish, Sarah, Bennett, Derrick, Chen, Wei-Min, Sundvall, Jouko, Timpson, Nicholas J, Sanna, Serena

“…To identify genetic variants influencing plasma lipid concentrations, we first used genotype imputation and meta-analysis to combine three genome-wide scans…”
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Use of microarray hybrid capture and next-generation sequencing to identify the anatomy of a transgene by Dubose, Amanda J, Lichtenstein, Stephen T, Narisu, Narisu, Bonnycastle, Lori L, Swift, Amy J, Chines, Peter S, Collins, Francis S

“…Transgenic animals are extensively used to model human disease. Typically, the transgene copy number is estimated, but the exact integration site and…”
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Enhancing Human Health and Wellbeing through Sustainably and Equitably Unlocking a Healthy Ocean's Potential by Fleming, Lora E, Landrigan, Philip J, Ashford, Oliver S, Whitman, Ella M, Swift, Amy, Gerwick, William H, Heymans, Johanna J, Hicks, Christina C, Morrissey, Karyn, White, Mathew P, Alcantara-Creencia, Lota, Alexander, Karen A, Astell-Burt, Thomas, Berlinck, Roberto G S, Cohen, Philippa J, Hixson, Richard, Islam, Mohammad Mahmudul, Iwasaki, Arihiro, Praptiwi, Radisti A, Raps, Hervé, Remy, Jan Yves, Sowman, Georgina, Ternon, Eva, Thiele, Torsten, Thilsted, Shakuntala H, Uku, Jacqueline, Ockenden, Stephanie, Kumar, Pushpam

“…A healthy ocean is essential for human health, and yet the links between the ocean and human health are often overlooked. By providing new medicines,…”
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The Role of Race in Admission to a Dual Diagnosis Unit Versus General Inpatient Psychiatric Unit in those with Active Substance Use by Sung, Calvin, Holbreich, Rachael, Swift, Amy, Kymissis, Carissa, Cohen, Lisa

“…Psychiatric disorders are highly comorbid with substance use disorders, and the presence of co-occurring conditions increases severity of illness and…”
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KSR2 Is an Essential Regulator of AMP Kinase, Energy Expenditure, and Insulin Sensitivity by Costanzo-Garvey, Diane L., Pfluger, Paul T., Dougherty, Michele K., Stock, Jeffery L., Boehm, Matthew, Chaika, Oleg, Fernandez, Mario R., Fisher, Kurt, Kortum, Robert L., Hong, Eun-Gyoung, Jun, John Y., Ko, Hwi Jin, Schreiner, Aimee, Volle, Deanna J., Treece, Tina, Swift, Amy L., Winer, Mike, Chen, Denise, Wu, Min, Leon, Lisa R., Shaw, Andrey S., McNeish, John, Kim, Jason K., Morrison, Deborah K., Tschöp, Matthias H., Lewis, Robert E.

“…Kinase suppressors of Ras 1 and 2 (KSR1 and KSR2) function as molecular scaffolds to potently regulate the MAP kinases ERK1/2 and affect multiple cell fates…”
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Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels by Chen, Wei-Min, Erdos, Michael R, Jackson, Anne U, Saxena, Richa, Sanna, Serena, Silver, Kristi D, Timpson, Nicholas J, Hansen, Torben, Orrù, Marco, Grazia Piras, Maria, Bonnycastle, Lori L, Willer, Cristen J, Lyssenko, Valeriya, Shen, Haiqing, Kuusisto, Johanna, Ebrahim, Shah, Sestu, Natascia, Duren, William L, Spada, Maria Cristina, Stringham, Heather M, Scott, Laura J, Olla, Nazario, Swift, Amy J, Najjar, Samer, Mitchell, Braxton D, Lawlor, Debbie A, Smith, George Davey, Ben-Shlomo, Yoav, Andersen, Gitte, Borch-Johnsen, Knut, Jørgensen, Torben, Saramies, Jouko, Valle, Timo T, Buchanan, Thomas A, Shuldiner, Alan R, Lakatta, Edward, Bergman, Richard N, Uda, Manuela, Tuomilehto, Jaakko, Pedersen, Oluf, Cao, Antonio, Groop, Leif, Mohlke, Karen L, Laakso, Markku, Schlessinger, David, Collins, Francis S, Altshuler, David, Abecasis, Gonçalo R, Boehnke, Michael, Scuteri, Angelo, Watanabe, Richard M

“…Identifying the genetic variants that regulate fasting glucose concentrations may further our understanding of the pathogenesis of diabetes. We therefore…”
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Re-sequencing expands our understanding of the phenotypic impact of variants at GWAS loci by Service, Susan K, Teslovich, Tanya M, Fuchsberger, Christian, Ramensky, Vasily, Yajnik, Pranav, Koboldt, Daniel C, Larson, David E, Zhang, Qunyuan, Lin, Ling, Welch, Ryan, Ding, Li, McLellan, Michael D, O'Laughlin, Michele, Fronick, Catrina, Fulton, Lucinda L, Magrini, Vincent, Swift, Amy, Elliott, Paul, Jarvelin, Marjo-Riitta, Kaakinen, Marika, McCarthy, Mark I, Peltonen, Leena, Pouta, Anneli, Bonnycastle, Lori L, Collins, Francis S, Narisu, Narisu, Stringham, Heather M, Tuomilehto, Jaakko, Ripatti, Samuli, Fulton, Robert S, Sabatti, Chiara, Wilson, Richard K, Boehnke, Michael, Freimer, Nelson B

“…Genome-wide association studies (GWAS) have identified >500 common variants associated with quantitative metabolic traits, but in aggregate such variants…”
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Single-cell transcriptomics from human pancreatic islets: sample preparation matters by Bonnycastle, Lori L, Gildea, Derek E, Yan, Tingfen, Narisu, Narisu, Swift, Amy J, Wolfsberg, Tyra G, Erdos, Michael R, Collins, Francis S

“…Abstract Single-cell RNA sequencing (scRNA-seq) of human primary tissues is a rapidly emerging tool for investigating human health and disease at the molecular…”
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Correlation of rare coding variants in the gene encoding human glucokinase regulatory protein with phenotypic, cellular, and kinetic outcomes by Rees, Matthew G, Ng, David, Ruppert, Sarah, Turner, Clesson, Beer, Nicola L, Swift, Amy J, Morken, Mario A, Below, Jennifer E, Blech, Ilana, Mullikin, James C, McCarthy, Mark I, Biesecker, Leslie G, Gloyn, Anna L, Collins, Francis S

“…Defining the genetic contribution of rare variants to common diseases is a major basic and clinical science challenge that could offer new insights into…”
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