Search Results - "Swietlicki, Elzbieta A."

Epimorphin deletion protects mice from inflammation-induced colon carcinogenesis and alters stem cell niche myofibroblast secretion by Shaker, Anisa, Swietlicki, Elzbieta A, Wang, Lihua, Jiang, Shujun, Onal, Birce, Bala, Shashi, DeSchryver, Katherine, Newberry, Rodney, Levin, Marc S, Rubin, Deborah C

“…Epithelial-mesenchymal interactions regulate normal gut epithelial homeostasis and have a putative role in inflammatory bowel disease and colon cancer…”
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Stem cell and niche regulation in human short bowel syndrome by Gazit, Vered A, Swietlicki, Elzbieta A, Liang, Miranda U, Surti, Adam, McDaniel, Raechel, Geisman, Mackenzie, Alvarado, David M, Ciorba, Matthew A, Bochicchio, Grant, Ilahi, Obeid, Kirby, John, Symons, William J, Davidson, Nicholas O, Levin, Marc S, Rubin, Deborah C

“…Loss of functional small bowel surface area following surgical resection for disorders such as Crohn's disease, intestinal ischemic injury, radiation…”
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Proline Absorption and SGK1 Expression are Inhibited in Intestinal Tis7 Transgenic Mice by Lu, Jianyun, Garcia, Amy M., Geisman, Taylor, Wakeman, Derek, Warner, Brad W., Swietlicki, Elzbieta A., Levin, Marc S., Rubin, Deborah C.

“…Background/Aims: Expression of the transcriptional co-regulator tis7 is markedly increased in the adaptive small intestine in a mouse model of short bowel…”
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Epimorphin expression in intestinal myofibroblasts induces epithelial morphogenesis by Fritsch, Christine, Swietlicki, Elzbieta A, Lefebvre, Olivier, Kedinger, Michele, Iordanov, Hristo, Levin, Marc S, Rubin, Deborah C

“…The formation of the crypt-villus axis during gut ontogeny requires continued reciprocal interactions between the endoderm and mesenchyme. Epimorphin/syntaxin…”
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Patient-derived small intestinal myofibroblasts direct perfused, physiologically responsive capillary development in a microfluidic Gut-on-a-Chip Model by Seiler, Kristen M., Bajinting, Adam, Alvarado, David M., Traore, Mahama A., Binkley, Michael M., Goo, William H., Lanik, Wyatt E., Ou, Jocelyn, Ismail, Usama, Iticovici, Micah, King, Cristi R., VanDussen, Kelli L., Swietlicki, Elzbieta A., Gazit, Vered, Guo, Jun, Luke, Cliff J., Stappenbeck, Thaddeus, Ciorba, Matthew A., George, Steven C., Meacham, J. Mark, Rubin, Deborah C., Good, Misty, Warner, Brad W.

“…The development and physiologic role of small intestine (SI) vasculature is poorly studied. This is partly due to a lack of targetable, organ-specific markers…”
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Epimorphin regulates the intestinal stem cell niche via effects on the stromal microenvironment by Vishy, Courtney E, Swietlicki, Elzbieta A, Gazit, Vered, Amara, Suneetha, Heslop, Gabriela, Lu, Jianyun, Levin, Marc S, Rubin, Deborah C

“…Stem cell therapy is a potential therapeutic approach for disorders characterized by intestinal injury or loss of functional surface area. Stem cell function…”
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Targeted Intestinal Overexpression of the Immediate Early Gene tis7 in Transgenic Mice Increases Triglyceride Absorption and Adiposity by Wang, Yuan, Iordanov, Hristo, Swietlicki, Elzbieta A., Wang, Lihua, Fritsch, Christine, Coleman, Trey, Semenkovich, Clay F., Levin, Marc S., Rubin, Deborah C.

“…Following loss of functional small bowel surface area due to surgical resection, the remnant gut undergoes an adaptive response characterized by increased…”
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377 Tis7 Deletion Inhibits Establishment and Growth of Crypt-Derived Intestinal Enteroids and Reduces Stem Cell Marker LGR5 Expression by Lu, Jianyun, Swietlicki, Elzbieta A, Vishy, Courtney, Geisman, Mackenzie, Levin, Marc S, Rubin, Deborah C

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Mo1859 Epimorphin Deletion in Intestinal Myofibroblasts Enhances Growth and Budding of Crypt Stem Cell Co-Cultures by Amara, Suneetha, Swietlicki, Elzbieta A, Lu, Jianyun, Vishy, Courtney, Levin, Marc S, Rubin, Deborah C

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Tis7 deletion reduces survival and induces intestinal anastomotic inflammation and obstruction in high-fat diet-fed mice with short bowel syndrome by Garcia, Amy M, Wakeman, Derek, Lu, Jianyun, Rowley, Christopher, Geisman, Taylor, Butler, Catherine, Bala, Shashi, Swietlicki, Elzbieta A, Warner, Brad W, Levin, Marc S, Rubin, Deborah C

“…Effective therapies are limited for patients with parenteral nutrition-dependent short bowel syndrome. We previously showed that intestinal expression of the…”
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Epimorphin deletion inhibits polyposis in the Apcmin/+ mouse model of colon carcinogenesis via decreased myofibroblast HGF secretion by Swietlicki, Elzbieta A, Bala, Shashi, Lu, Jianyun, Shaker, Anisa, Kularatna, Gowri, Levin, Marc S, Rubin, Deborah C

“…Interactions between the epithelium and surrounding mesenchyme/stroma play an important role in normal gut morphogenesis, the epithelial response to injury,…”
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Tu1224 Reduced Proline Absorption in Intestinal TIS7 Transgenic Mice Is Associated With Decreased Apical Cell Surface Expression of the Amino Acid Transporter SLC6A20, Mediated by Serum and Glucocorticoid-Induced Kinase 1 by Lu, Jianyun, Garcia, Amy M, Geisman, Taylor, Wakeman, Derek, Warner, Brad, Swietlicki, Elzbieta A, Levin, Marc S, Rubin, Deborah C

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Su1748 Esophageal Myofibroblasts in Neonatal and Adult Murine Esophagus Respond to Acidic Injury With an Increase in BMP4 and IL-6 Secretion by Binkley, Jana, Darwech, Isra, Swietlicki, Elzbieta A, Levin, Marc S, Rubin, Deborah C, Shaker, Anisa

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Epimorphin(-/-) mice have increased intestinal growth, decreased susceptibility to dextran sodium sulfate colitis, and impaired spermatogenesis by Wang, Yuan, Wang, Lihua, Iordanov, Hristo, Swietlicki, Elzbieta A, Zheng, Qun, Jiang, Shujun, Tang, Yuzhu, Levin, Marc S, Rubin, Deborah C

“…Dynamic and reciprocal epithelial-mesenchymal interactions are critical for the normal morphogenesis and maintenance of epithelia. Epimorphin has been…”
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Deletion of Tis7 protects mice from high-fat diet-induced weight gain and blunts the intestinal adaptive response postresection by Yu, Cong, Jiang, Shujun, Lu, Jianyun, Coughlin, Carrie C, Wang, Yuan, Swietlicki, Elzbieta A, Wang, Lihua, Vietor, Ilja, Huber, Lukas A, Cikes, Domagoj, Coleman, Trey, Xie, Yan, Semenkovich, Clay F, Davidson, Nicholas O, Levin, Marc S, Rubin, Deborah C

“…After loss of intestinal surface area, the remaining bowel undergoes a morphometric and functional adaptive response. Enterocytic expression of the…”
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S1687 Deletion of Epimorphin From Colonic Myofibroblasts Results in Aberrant Protein Secretion, Increased Endoplasmic Reticulum Stress and Altered Epithelial-Mesenchymal Interactions by Shaker, Anisa, Swietlicki, Elzbieta A, Deschryver, Katherine, Wang, Lihua, Levin, Marc S, Rubin, Deborah C

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Bax is required for resection-induced changes in apoptosis, proliferation, and members of the extrinsic cell death pathways by Tang, Yuzhu, Swartz-Basile, Deborah A, Swietlicki, Elzbieta A, Yi, Lu, Rubin, Deborah C, Levin, Marc S

“…To define better the homeostatic mechanisms contributing to small intestinal adaptation following partial resection, the relative contributions of apoptosis,…”
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W1564 Epimorphin Deletion Markedly Reduces Dysplasia in the Murine Azoxymethane/Dextran Sodium Sulfate Colitis-Associated Carcinogenesis Model by Shaker, Anisa, Onal, Birce, Swietlicki, Elzbieta A, Jiang, Shujun, Wang, Lihua, Rubin, Deborah C, Levin, Marc S

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Increased apoptosis and accelerated epithelial migration following inhibition of hedgehog signaling in adaptive small bowel postresection by Tang, Yuzhu, Swietlicki, Elzbieta A, Jiang, Shujun, Buhman, Kim K, Davidson, Nicholas O, Burkly, Linda C, Levin, Marc S, Rubin, Deborah C

“…The intestinal epithelium undergoes a marked adaptive response following loss of functional small bowel surface area characterized by increased crypt cell…”
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T1822 Deletion of Epimorphin Alters Colonic Myofibroblast Function and Affects Colonic Epithelial Proliferation by Shaker, Anisa, Swietlicki, Elzbieta A, Wang, Lihua, Jiang, Shujun, Wang, Qiuling, Rowley, Christopher, Coughlin, Carrie C, Levin, Marc S, Rubin, Deborah C

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