Search Results - "Swertfeger, Debi K"

A novel assay to measure low-density lipoproteins binding to proteoglycans by Geh, Esmond N, Swertfeger, Debi K, Sexmith, Hannah, Heink, Anna, Tarapore, Pheruza, Melchior, John T, Davidson, W Sean, Shah, Amy Sanghavi

“…The binding of low-density lipoprotein (LDL) to proteoglycans (PGs) in the extracellular matrix (ECM) of the arterial intima is a key initial step in the…”
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Apolipoprotein A-II alters the proteome of human lipoproteins and enhances cholesterol efflux from ABCA1 by Melchior, John T., Street, Scott E., Andraski, Allison B., Furtado, Jeremy D., Sacks, Frank M., Shute, Rebecca L., Greve, Emily I., Swertfeger, Debi K., Li, Hailong, Shah, Amy S., Lu, L. Jason, Davidson, W. Sean

“…HDLs are a family of heterogeneous particles that vary in size, composition, and function. The structure of most HDLs is maintained by two scaffold proteins,…”
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Pregnancy is accompanied by larger high density lipoprotein particles and compositionally distinct subspecies by Melchior, John T., Swertfeger, Debi K., Morris, Jamie, Street, Scott E., Warshak, Carri R., Welge, Jeffrey A., Remaley, Alan T., Catov, Janet M., Davidson, W. Sean, Woollett, Laura A.

“…Pregnancy is accompanied by significant physiological changes, which can impact the health and development of the fetus and mother. Pregnancy-induced changes…”
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Mapping Atheroprotective Functions and Related Proteins/Lipoproteins in Size Fractionated Human Plasma by Swertfeger, Debi K., Li, Hailong, Rebholz, Sandra, Zhu, Xiaoting, Shah, Amy S., Davidson, W. Sean, Lu, Long J.

“…HDL has been shown to possess a variety of cardio-protective functions, including removal of excess cholesterol from the periphery, and inhibition of…”
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Lipoprotein subfraction patterns throughout gestation in The Gambia: changes in subfraction composition and their relationships with infant birth weights by Woo, Jessica G, Melchior, John T, Swertfeger, Debi K, Remaley, Alan T, Sise, Ebrima A, Sosseh, Fatou, Welge, Jeffrey A, Prentice, Andrew M, Davidson, W Sean, Moore, Sophie E, Woollett, Laura A

“…Lipoprotein subfraction concentrations have been shown to change as gestation progresses in resource-rich settings. The objective of the current study was to…”
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High-Density Lipoproteins-Associated Proteins and Subspecies Related to Arterial Stiffness in Young Adults with Type 2 Diabetes Mellitus by Lu, L. Jason, Davidson, W. Sean, Melchior, John T., Ren, Sheng, Li, Hailong, Swertfeger, Debi K., Shah, Amy S., Zhu, Xiaoting, Gordon, Scott M.

“…Lower plasma levels of high-density lipoproteins (HDL) in adolescents with type 2 diabetes (T2D) have been associated with a higher pulse wave velocity (PWV),…”
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The Difference Between High Density Lipoprotein Subfractions and Subspecies: an Evolving Model in Cardiovascular Disease and Diabetes by Davidson, W. Sean, Cooke, Allison L., Swertfeger, Debi K., Shah, Amy S.

“…Purpose of Review The term high density lipoproteins (HDL) refers to an eclectic collection of subparticles that play diverse roles in physiology. Here, we…”
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Low Density Lipoprotein Receptor-related Protein Mediates Apolipoprotein E Inhibition of Smooth Muscle Cell Migration by Swertfeger, Debi K., Bu, Guojun, Hui, David Y.

“…This research was undertaken to identify the cell surface receptor responsible for mediating apolipoprotein E (apoE) inhibition of platelet-derived growth…”
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Feasibility of a plasma bioassay to assess oxidative protection of low-density lipoproteins by high-density lipoproteins by Swertfeger, Debi K., Rebholz, Sandra, Li, Hailong, Shah, Amy S., Davidson, William Sean, Lu, Long J.

“…Traditionally, the impact of lipoproteins on vascular disease has been evaluated in light of their quantity, that is, cholesterol content, in plasma. However,…”
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A Comparison of Methods To Enhance Protein Detection of Lipoproteins by Mass Spectrometry by Heink, Anna, Davidson, W. Sean, Swertfeger, Debi K, Lu, L. Jason, Shah, Amy S

“…We sought to develop a new method to more efficiently analyze lipid-bound proteins by mass spectrometry using a combination of a lipid removal agent (LRA) that…”
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Network-Based Analysis on Orthogonal Separation of Human Plasma Uncovers Distinct High Density Lipoprotein Complexes by Li, Hailong, Gordon, Scott M, Zhu, Xiaoting, Deng, Jingyuan, Swertfeger, Debi K, Davidson, W. Sean, Lu, L. Jason

“…High density lipoprotein (HDL) particles are blood-borne complexes whose plasma levels have been associated with protection from cardiovascular disease (CVD)…”
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Apolipoprotein E Inhibits Platelet-derived Growth Factor-induced Vascular Smooth Muscle Cell Migration and Proliferation by Suppressing Signal Transduction and Preventing Cell Entry to G1 Phase by Ishigami, Masato, Swertfeger, Debi K., Granholm, Norman A., Hui, David Y.

“…The anti-atherogenic effects of apolipoprotein (apo) E have been attributed to its ability to reduce plasma cholesterol level and to limit foam cell formation…”
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Apolipoprotein AIV: a potent endogenous inhibitor of lipid oxidation by Qin, X, Swertfeger, D K, Zheng, S, Hui, D Y, Tso, P

“…Overexpression of apolipoprotein (apo) AIV in transgenic mice confers significant protection against atherosclerosis in apoE knockout animals even in the…”
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Apolipoprotein E Inhibition of Vascular Smooth Muscle Cell Proliferation but Not the Inhibition of Migration Is Mediated Through Activation of Inducible Nitric Oxide Synthase by Ishigami, Masato, Swertfeger, Debi K, Hui, Michele S, Granholm, Norman A, Hui, David Y

“…ABSTRACTInitial experiments revealed that low concentrations of apolipoprotein (apo) E (0.1 to 5 μg/mL) were effective in inhibiting platelet-derived growth…”
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Distinct Apolipoprotein E Isoform Preference for Inhibition of Smooth Muscle Cell Migration and Proliferation by Zeleny, Michelle, Swertfeger, Debi K, Weisgraber, Karl H, Hui, David Y

“…The current study compared the effectiveness of the various human apolipoprotein E (apoE) isoforms in inhibiting platelet-derived growth factor- (PDGF-)…”
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Abstract 1026: Apolipoprotein A1 On High-density Lipoprotein Interferes With Low-density Lipoprotein Binding To Proteoglycans by Geh, Esmond, Roscoe, Isabella, Swertfeger, Debi K, Bursey, Alexiana, Tarapore, Pheruza, Sexmith, Hannah, Davidson, William, Shah, Amy S

“…Abstract only Background: The entrapment of apolipoprotein (APO) B-100 containing low density lipoproteins (LDL) by proteoglycans (PGs) in the extracellular…”
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Apolipoprotein E Receptor Binding VersusHeparan Sulfate Proteoglycan Binding in Its Regulation of Smooth Muscle Cell Migration and Proliferation by Swertfeger, Debi K., Hui, David Y.

“…This study showed that synthetic peptides containing either a single copy or tandem repeat of the receptor binding domain sequence of apolipoprotein (apo) E,…”
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Apolipoprotein J/clusterin induction in myocarditis: A localized response gene to myocardial injury by Swertfeger, DK, Witte, DP, Stuart, WD, Rockman, HA, Harmony, JA

“…The function of apolipoprotein J (apoJ) is unknown, but it has been hypothesized to be cytoprotective. In the normal heart, abundant apoJ mRNA and protein are…”
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Apolipoprotein E receptor binding versus heparan sulfate proteoglycan binding in its regulation of smooth muscle cell migration and proliferation by Swertfeger, D K, Hui, D Y

“…This study showed that synthetic peptides containing either a single copy or tandem repeat of the receptor binding domain sequence of apolipoprotein (apo) E,…”
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Apolipoprotein J/Clusterin Expression Defines Distinct Stages of Blastocyst Implantation in the Mouse Uterus1 by Brown, Thomas L., Moulton, Bruce C., Witte, David P., Swertfeger, Debi K., Harmony, A. K.

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