Search Results - "Sweitzer, Sarah"

Compounded Pain Formulations: What is the Evidence? by Asbill, Scott, Sweitzer, Sarah M, Spigener, Shuler, Romero-Sandoval, Alfonso

“…Pain syndromes are among the most widespread, costly, and debilitating of all neurological disorders. The number of patients living with chronic pain is…”
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Evidence for the endothelin system as an emerging therapeutic target for the treatment of chronic pain by Smith, Terika P, Haymond, Tami, Smith, Sherika N, Sweitzer, Sarah M

“…Many people worldwide suffer from pain and a portion of these sufferers are diagnosed with a chronic pain condition. The management of chronic pain continues…”
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Endothelin-1-induced priming to capsaicin in young animals by Smith, Terika, Beasley, Sarah, Smith, Sherika, Mark, Isiasha, Sweitzer, Sarah M.

“…•Capsaicin produced sex-dependent secondary mechanical hyperalgesia in neonatal rats.•Secondary mechanical hyperalgesia was prolonged in ET-1 primed…”
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Modulation of pain in pediatric sickle cell disease: Understanding the balance between endothelin mediated vasoconstriction and apelin mediated vasodilation by Smith, Terika P., Schlenz, Alyssa M., Schatz, Jeffrey C., Maitra, Rangan, Sweitzer, Sarah M.

“…Children with sickle cell disease (SCD) have painful vaso-occlusive episodes (VOEs), which often reoccur across the individual's lifespan. Vaso-constrictive…”
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Endothelin-1 induced desensitization in primary afferent neurons by Smith, Terika P., Smith, Sherika N., Sweitzer, Sarah M.

“…•ET-1 causes increase in Ca2+ transients in unprimed dorsal root ganglion neurons.•ET-1 priming has a desensitizing effect on subsequent exposures to…”
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Tolerance develops to the antiallodynic effects of the peripherally acting opioid loperamide hydrochloride in nerve-injured rats by He, Shao-Qiu, Yang, Fei, Perez, Federico M., Xu, Qian, Shechter, Ronen, Cheong, Yong-Kwan, Carteret, Alene F., Dong, Xinzhong, Sweitzer, Sarah M., Raja, Srinivasa N., Guan, Yun

“…This study suggests that animals with neuropathic pain develop acute tolerance to the antiallodynic effects of peripherally acting opioids after repetitive…”
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Injury-specific promoters enhance herpes simplex virus-mediated gene therapy for treating neuropathic pain in rodents by Smith, Sherika N, Paige, Candler, Velazquez, Kandy T, Smith, Terika P, Raja, Srinivasa N, Wilson, Steven P, Sweitzer, Sarah M

“…Chronic neuropathic pain is often difficult to treat with current pain medications. Gene therapy is presently being explored as a therapeutic approach for the…”
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Neonatal morphine enhances nociception and decreases analgesia in young rats by Zhang, Guo Hua, Sweitzer, Sarah M

“…Abstract The recognition of the impact of neonatal pain experience on subsequent sensory processing has led to the increased advocacy for the use of opioids…”
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Metabotropic glutamate receptor-5 and protein kinase C-epsilon increase in dorsal root ganglion neurons and spinal glial activation in an adolescent rat model of painful neck injury by Weisshaar, Christine L, Dong, Ling, Bowman, Alex S, Perez, Federico M, Guarino, Benjamin B, Sweitzer, Sarah M, Winkelstein, Beth A

“…There is growing evidence that neck pain is common in adolescence and is a risk factor for the development of chronic neck pain in adulthood. The cervical…”
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Dynamic temporal and spatial regulation of mu opioid receptor expression in primary afferent neurons following spinal nerve injury by Lee, Chun-Yi, Perez, Federico M, Wang, Wei, Guan, Xiaowei, Zhao, Xiuli, Fisher, Janet L, Guan, Yun, Sweitzer, Sarah M, Raja, Srinivasa N, Tao, Yuan-Xiang

“…Abstract Despite using prescribed pain medications, patients with neuropathic pain continue to experience moderate to severe pain. There is a growing…”
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Endothelin-1 exposure on postnatal day 7 alters expression of the endothelin B receptor and behavioral sensitivity to endothelin-1 on postnatal day 11 by McKelvy, Alvin D., Sweitzer, Sarah M.

“…Endothelin (ET)-1 is a chemical mediator released by the body at sites of injury and disease and is involved in various painful states. This study examined…”
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Enhanced Peripheral Analgesia Using Virally Mediated Gene Transfer of the μ-Opioid Receptor in Mice by GUOHUA ZHANG, MOHAMMAD, Husam, PEPER, Brad D, RAJA, Srinivasa, WILSON, Steven P, SWEITZER, Sarah M

“…The use of opioids to treat pain is often limited by side effects mediated through the central nervous system. The current study used a recombinant herpes…”
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Decreased opioid analgesia in weanling rats exposed to endothelin-1 during infancy by McKelvy, Alvin D., Sweitzer, Sarah M.

“…Endothelin-1 produces spontaneous nociceptive-associated behaviors that are modulated by the peripheral opioid system. The present study tests the hypothesis…”
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Protein kinase C in pain: Involvement of multiple isoforms by Velázquez, Kandy T., Mohammad, Husam, Sweitzer, Sarah M.

“…Pain is the primary reason that people seek medical care. At present, chronic unremitting pain is the third greatest health problem after heart disease and…”
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Sensitization to acute procedural pain in pediatric sickle cell disease: modulation by painful vaso-occlusive episodes, age, and endothelin-1 by Schlenz, Alyssa M, McClellan, Catherine B, Mark, Teresa R M, McKelvy, Alvin D, Puffer, Eve, Roberts, Carla W, Sweitzer, Sarah M, Schatz, Jeffrey C

“…The impact of pain early in life is a salient issue for sickle cell disease (SCD), a genetic condition characterized by painful vaso-occlusive episodes (VOEs)…”
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Compounded pain formulations: what is the evidence? by Asbill, Scott, Sweitzer, Sarah M, Spigener, Shuler, Romero-Sandoval, Alfonso

“…Pain syndromes are among the most widespread, costly, and debilitating of all neurological disorders. The number of patients living with chronic pain is…”
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Focal peripheral nerve injury induces leukocyte trafficking into the central nervous system: potential relationship to neuropathic pain by Sweitzer, Sarah M, Hickey, William F, Rutkowski, Maria D, Pahl, Janice L, DeLeo, Joyce A

“…The present study was undertaken to determine whether leukocytes are recruited into the spinal cord following a peripheral L5 spinal nerve transection that…”
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Protein kinase C epsilon and gamma: involvement in formalin-induced nociception in neonatal rats by Sweitzer, Sarah M, Wong, Shirley M E, Peters, Michael C, Mochly-Rosen, Daria, Yeomans, David C, Kendig, Joan J

“…The central nervous system undergoes dynamic changes as it matures. However, until recently, very little was known about the impact of these changes on pain…”
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Antinociceptive action of a p38α MAPK inhibitor, SD-282, in a diabetic neuropathy model by Sweitzer, Sarah M., Medicherla, Satyanarayana, Almirez, Ramona, Dugar, Sundeep, Chakravarty, Sarvajit, Shumilla, Jennifer A., Yeomans, David C., Protter, Andrew A.

“…Diabetes can induce a bewildering list of sensory changes, including alteration in pain sensitivity. Painful diabetic neuropathy is refractory to most common…”
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Information-Seeking Coping Behaviors During Painful Procedures in African-American Children with Sickle Cell Disease by Schlenz, Alyssa M., Schatz, Jeffrey, McClellan, Catherine B., Sweitzer, Sarah M., Roberts, Carla W.

“…This study examined the frequency of information-seeking coping behaviors in 37 African-American children (ages 5-17 years) with sickle cell disease during…”
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