Search Results - "Sweezey, Neil"

The cystic fibrosis gender gap: Potential roles of estrogen by Sweezey, Neil B., Ratjen, Felix

“…Summary Cystic fibrosis (CF) is a complex, multi‐system, autosomal recessive disease predominantly affecting Caucasians that leads to vigorous airway…”
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Estrogen aggravates inflammation in Pseudomonas aeruginosa pneumonia in cystic fibrosis mice by Wang, Yufa, Cela, Elvis, Gagnon, Stéphane, Sweezey, Neil B

“…Among patients with cystic fibrosis (CF), females have worse pulmonary function and survival than males, primarily due to chronic lung inflammation and…”
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JNK Activation Turns on LPS- and Gram-Negative Bacteria-Induced NADPH Oxidase-Dependent Suicidal NETosis by Khan, Meraj A., Farahvash, Armin, Douda, David N., Licht, Johann-Christoph, Grasemann, Hartmut, Sweezey, Neil, Palaniyar, Nades

“…Neutrophils cast neutrophil extracellular traps (NETs) to ensnare microbial pathogens. Nevertheless, the molecular rheostats that regulate NETosis in response…”
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Intrinsic predisposition of naïve cystic fibrosis T cells to differentiate towards a Th17 phenotype by Kushwah, Rahul, Gagnon, Stéphane, Sweezey, Neil B

“…Cystic fibrosis (CF) is a complex, multi-system, life-shortening, autosomal recessive disease most common among Caucasians. Pulmonary pathology, the major…”
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LGL1 modulates proliferation, apoptosis, and migration of human fetal lung fibroblasts by Zhang, Hui, Sweezey, Neil B, Kaplan, Feige

“…Rapid growth and formation of new gas exchange units (alveogenesis) are hallmarks of the perinatal lung. Bronchopulmonary dysplasia (BPD), common in very…”
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Alkaline pH Promotes NADPH Oxidase-Independent Neutrophil Extracellular Trap Formation: A Matter of Mitochondrial Reactive Oxygen Species Generation and Citrullination and Cleavage of Histone by Naffah de Souza, Cristiane, Breda, Leandro C D, Khan, Meraj A, de Almeida, Sandro Rogério, Câmara, Niels Olsen Saraiva, Sweezey, Neil, Palaniyar, Nades

“…pH is highly variable in different tissues and affects many enzymatic reactions in neutrophils. In response to calcium ionophores such as A23187 and ionomycin,…”
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Two-in-one: UV radiation simultaneously induces apoptosis and NETosis by Azzouz, Dhia, Khan, Meraj A., Sweezey, Neil, Palaniyar, Nades

“…NETosis is a unique form of neutrophil death that differs from apoptosis and necrosis. However, whether NETosis and apoptosis can occur simultaneously in the…”
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Regulating NETosis: Increasing pH Promotes NADPH Oxidase-Dependent NETosis by Khan, Meraj A, Philip, Lijy M, Cheung, Guillaume, Vadakepeedika, Shawn, Grasemann, Hartmut, Sweezey, Neil, Palaniyar, Nades

“…Neutrophils migrating from the blood (pH 7.35-7.45) into the surrounding tissues encounter changes in extracellular pH (pH ) conditions. Upon activation of…”
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Efficacy of high‐dose steroids for bronchiolitis obliterans syndrome post pediatric hematopoietic stem cell transplantation by Even‐Or, Ehud, Ghandourah, Hasan, Ali, Muhammad, Krueger, Joerg, Sweezey, Neil B., Schechter, Tal

“…BOS is the pulmonary manifestation of cGvHD post‐allogeneic HSCT. Survival and treatment of this often fatal complication have not improved over the last…”
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Reduced viability of mice with lung epithelial-specific knockout of glucocorticoid receptor by Manwani, Neetu, Gagnon, Stéphane, Post, Martin, Joza, Stephen, Muglia, Louis, Cornejo, Salomon, Kaplan, Feige, Sweezey, Neil B

“…Glucocorticoid (GC)-responsive epithelial-mesenchymal interactions regulate lung development. The GC receptor (GR) mediates GC signaling. Mice lacking GR in…”
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Inflammatory cytokines, goblet cell hyperplasia and altered lung mechanics in Lgl1+/- mice by Lan, Jie, Ribeiro, Leslie, Mandeville, Isabel, Nadeau, Katia, Bao, Tim, Cornejo, Salomon, Sweezey, Neil B, Kaplan, Feige

“…Neonatal lung injury, a leading cause of morbidity in prematurely born infants, has been associated with arrested alveolar development and is often accompanied…”
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T cell unresponsiveness in a pediatric cystic fibrosis patient: a case report by Kushwah, Rahul, Gagnon, Stéphane, Sweezey, Neil B

“…A girl was diagnosed with cystic fibrosis (CF) at birth, with repeatedly positive sweat tests and homozygous F508del mutations of her CF transmembrane…”
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Opposing Effects of 60% Oxygen and Neutrophil Influx on Alveologenesis in the Neonatal Rat by Yi, Man, Jankov, Robert P, Belcastro, Rosetta, Humes, Daryl, Copland, Ian, Shek, Samuel, Sweezey, Neil B, Post, Martin, Albertine, Kurt H, Auten, Richard L, Tanswell, A. Keith

“…The lungs of newborn rats exposed to 60% oxygen for 14 days develop an injury that shares morphologic similarities to human bronchopulmonary dysplasia (BPD)…”
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CRISPLD2 (LGL1) inhibits proinflammatory mediators in human fetal, adult, and COPD lung fibroblasts and epithelial cells by Zhang, Hui, Kho, Alvin T., Wu, Qing, Halayko, Andrew J., Limbert Rempel, Karen, Chase, Robert P., Sweezey, Neil B., Weiss, Scott T., Kaplan, Feige

“…Chronic lung disease of prematurity/bronchopulmonary dysplasia (BPD) is the leading cause of perinatal morbidity in developed countries. Inflammation is a…”
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Ultraviolet irradiation increases green fluorescence of dihydrorhodamine (DHR) 123: false‐positive results for reactive oxygen species generation by Djiadeu, Pascal, Azzouz, Dhia, Khan, Meraj A., Kotra, Lakshmi P., Sweezey, Neil, Palaniyar, Nades

“…Dihydrorhodamine (DHR) 123 is a fluorophore commonly used for measuring reactive oxygen species (ROS), often after exposing cells to ultraviolet (UV)…”
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Modulation of Lgl1 by Steroid, Retinoic Acid, and Vitamin D Models Complex Transcriptional Regulation During Alveolarization by Nadeau, Katia, Montermini, Laura, Mandeville, Isabel, Xu, Mousheng, Weiss, Scott T, Sweezey, Neil B, Kaplan, Feige

“…Alveolarization depends on circulating glucocorticoid (GC), retinoid (RA), and vitamin D (VitD). Bronchopulmonary dysplasia, a leading cause of neonatal…”
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LGL1, a novel branching morphogen in developing kidney, is induced by retinoic acid by Quinlan, Jacklyn, Kaplan, Feige, Sweezey, Neil, Goodyer, Paul

“…Late-gestation lung protein 1 (LGL1) is a glycoprotein secreted by fetal lung mesenchyme that stimulates branching morphogenesis of the developing lung bud. We…”
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The angiogenic factor midkine is regulated by dexamethasone and retinoic acid during alveolarization and in alveolar epithelial cells by Zhang, Huayan, Garber, Samuel J, Cui, Zheng, Foley, Joseph P, Mohan, Gopi S, Jobanputra, Minesh, Kaplan, Feige, Sweezey, Neil B, Gonzales, Linda W, Savani, Rashmin C

“…A precise balance exists between the actions of endogenous glucocorticoids (GC) and retinoids to promote normal lung development, in particular during…”
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Lung Inflammation as a Therapeutic Target in Cystic Fibrosis by Koehler, David R, Downey, Gregory P, Sweezey, Neil B, Tanswell, A. Keith, Hu, Jim

“…Cystic fibrosis (CF) lung disease is characterized by chronic neutrophilic inflammation and infection. Effective management of airway inflammation could…”
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Lgl1, a mesenchymal modulator of early lung branching morphogenesis, is a secreted glycoprotein imported by late gestation lung epithelial cells by Oyewumi, Lami, Kaplan, Feige, Sweezey, Neil B

“…Secreted glycoproteins serve a variety of functions related to cell-cell communication in developmental systems. We cloned LGL1, a novel…”
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