Search Results - "Sweet, RW"

Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody by Hendrickson, Wayne A, Kwong, Peter D, Wyatt, Richard, Robinson, James, Sweet, Raymond W, Sodroski, Joseph

“…The entry of human immunodeficiency virus (HIV) into cells requires the sequential interaction of the viral exterior envelope glycoprotein, gp120, with the CD4…”
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The antigenic structure of the HIV gp120 envelope glycoprotein by Sodroski, Joseph G, Wyatt, Richard, Kwong, Peter D, Desjardins, Elizabeth, Sweet, Raymond W, Robinson, James, Hendrickson, Wayne A

“…The human immunodeficiency virus HIV-1 establishes persistent infections in humans which lead to acquired immunodeficiency syndrome (AIDS). The HIV-1 envelope…”
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Energetics of the HIV gp120-CD4 binding reaction by Myszka, D G, Sweet, R W, Hensley, P, Brigham-Burke, M, Kwong, P D, Hendrickson, W A, Wyatt, R, Sodroski, J, Doyle, M L

“…HIV infection is initiated by the selective interaction between the cellular receptor CD4 and gp120, the external envelope glycoprotein of the virus. We used…”
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Structures of HIV-1 gp120 Envelope Glycoproteins from Laboratory-Adapted and Primary Isolates by Kwong, Peter D., Wyatt, Richard, Majeed, Shahzad, Robinson, James, Sweet, Raymond W., Sodroski, Joseph, Hendrickson, Wayne A.

“…Background: The gp120 exterior envelope glycoprotein of HIV-1 binds sequentially to CD4 and chemokine receptors on cells to initiate virus entry. During…”
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The TNF Superfamily Members LIGHT and CD154 (CD40 Ligand) Costimulate Induction of Dendritic Cell Maturation and Elicit Specific CTL Activity by Morel, Yannis, Truneh, Alemseged, Sweet, Raymond W, Olive, Daniel, Costello, Regis T

“…LIGHT is a recently identified member of the TNF superfamily that is up-regulated upon activation of T cells. Herpesvirus entry mediator, one of its receptors,…”
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Reciprocal Expression of the TNF Family Receptor Herpes Virus Entry Mediator and Its Ligand LIGHT on Activated T Cells: LIGHT Down-Regulates Its Own Receptor by Morel, Yannis, Schiano de Colella, Jean-Marc, Harrop, Jeremy, Deen, Keith C, Holmes, Stephen D, Wattam, Trevor A, Khandekar, Sanjay S, Truneh, Alemseged, Sweet, Raymond W, Gastaut, Jean-Albert, Olive, Daniel, Costello, Regis T

“…The TNF receptor (TNFR) family plays a central role in the development of the immune response. Here we describe the reciprocal regulation of the recently…”
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Elimination of Fc Receptor-Dependent Effector Functions of a Modified IgG4 Monoclonal Antibody to Human CD4 by Reddy, Manjula P, Kinney, Cheryl Ann S, Chaikin, Margery A, Payne, Angela, Fishman-Lobell, Jacqueline, Tsui, Ping, Dal Monte, Paul R, Doyle, Michael L, Brigham-Burke, Michael R, Anderson, Darrell, Reff, Mitchell, Newman, Roland, Hanna, Nabil, Sweet, Raymond W, Truneh, Alemseged

“…Several CD4 mAbs have entered the clinic for the treatment of autoimmune diseases or transplant rejection. Most of these mAbs caused CD4 cell depletion, and…”
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Probability Analysis of Variational Crystallization and Its Application to gp120, The Exterior Envelope Glycoprotein of Type 1 Human Immunodeficiency Virus (HIV-1) by Kwong, P D, Wyatt, R, Desjardins, E, Robinson, J, Culp, J S, Hellmig, B D, Sweet, R W, Sodroski, J, Hendrickson, W A

“…The extensive glycosylation and conformational mobility of gp120, the envelope glycoprotein of type 1 human immunodeficiency virus (HIV-1), pose formidable…”
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Stimulation of non-Hodgkin's lymphoma via HVEM: an alternate and safe way to increase Fas-induced apoptosis and improve tumor immunogenicity by COSTELLO, R. T, MALLET, F, BARBARAT, B, DE COLELLA, J-M Schiano, SAINTY, D, SWEET, R. W, TRUNEH, A, OLIVE, D

“…Stimulation by CD40 ligand (L) improves B-cell malignancy immunogenicity, and also induces proliferative signals. To avoid these tumorigenic effects, we…”
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Crystal structure of an HIV-binding recombinant fragment of human CD4 by Ryu, Seong-Eon, Kwong, Peter D, Truneh, Alemseged, Porter, Terence G, Arthos, James, Rosenberg, Martin, Dai, Xiaoping, Xuong, Nguyen-huu, Axel, Richard, Sweet, Raymond W, Hendrickson, Wayne A

“…CD4 glycoprotein on the surface of T cells helps in the immune response and is the receptor for HIV infection. The structure of a soluble fragment of CD4…”
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Analysis of the site of interaction of CD28 with its counter-receptors CD80 and CD86 and correlation with function by Kariv, I, Truneh, A, Sweet, R W

“…CD28 and CTLA-4 are homologue members of the Ig superfamily of molecules, containing a single V-like domain, transmembrane, and cytoplasmic regions. Both…”
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Modification of the Fc Region of a Primatized IgG Antibody to Human CD4 Retains Its Ability to Modulate CD4 Receptors but Does Not Deplete CD4+ T Cells in Chimpanzees by Newman, Roland, Hariharan, Kandasamy, Reff, Mitchell, Anderson, Darrel R., Braslawsky, Gary, Santoro, Denise, Hanna, Nabil, Bugelski, Peter J., Brigham-Burke, Michael, Crysler, Carl, Gagnon, Robert C., Dal Monte, Paul, Doyle, Michael L., Hensley, Preston C., Reddy, Manjula P., Sweet, Raymond W., Truneh, Alemseged

“…Keliximab, a Primatized IgG1 CD4 mAb, was reconfigured to an IgG4 antibody. The γ4 constant region was further modified by substituting glutamic acid for…”
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soluble form of CD4 (T4) protein inhibits AIDS virus infection by Deen, Keith C, McDougal, J. Steven, Inacker, Richard, Folena-Wasserman, Gail, Arthos, Jim, Rosenberg, Jonathan, Maddon, Paul Jay, Axel, Richard, Sweet, Raymond W

“…CD4 (T4) is a glycoprotein of relative molecular mass 55,000 (Mr 55K) on the surface of T lymphocytes which is thought to interact with class II MHC (major…”
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Soluble CD4 blocks the infectivity of diverse strains of HIV and SIV for T cells and monocytes but not for brain and muscle cells by Clapham, Paul R, Weber, Jonathan N, Whitby, Denise, McIntosh, Kenneth, Dalgleish, Angus G, Maddon, Paul J, Deen, Keith C, Sweet, Raymond W, Weiss, Robin A

“…The CD4 antigen has been subverted as a receptor by the human and simian immunodeficiency viruses (HIV-1, HIV-2 and SIV). Several groups have reported that…”
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Binding of Soluble CD4 Proteins to Human Immunodeficiency Virus Type 1 and Infected Cells Induces Release of Envelope Glycoprotein gp120 by Hart, Timothy K., Kirsh, Richard, Ellens, Harma, Sweet, Raymond W., Lambert, Dennis M., Petteway, Stephen R., Leary, Jeffry, Bugelski, Peter J.

“…Human immunodeficiency virus (HIV) infects cells after binding of the viral envelope glycoprotein gp120 to the cell surface recognition marker CD4. gp120 is…”
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Identification of the residues in human CD4 critical for the binding of HIV by Arthos, J, Deen, K C, Chaikin, M A, Fornwald, J A, Sathe, G, Sattentau, Q J, Clapham, P R, Weiss, R A, McDougal, J S, Pietropaolo, C

“…The CD4 molecule is a T cell surface glycoprotein that interacts with high affinity with the envelope glycoprotein of the human immunodeficiency virus, HIV,…”
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Kinetic and Structural Analysis of Mutant CD4 Receptors that are Defective in HIV gp120 Binding by Wu, Hao, Myszka, David G., Tendian, Susan W., Brouillette, Christie G., Sweet, Ray W., Chaiken, Irwin M., Hendrickson, Wayne A.

“…The T-cell antigen coreceptor CD4 also serves as the receptor for the envelope glycoprotein gp120 of HIV. Extensive mutational analysis of CD4 has implicated…”
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Progressive epitope-blocked panning of a phage library for isolation of human RSV antibodies by Tsui, Ping, Tornetta, Mark A., Ames, Robert S., Silverman, Carol, Porter, Terence, Weston, Cynthia, Griego, Sandra, Sweet, Raymond W.

“…Epitope-blocked panning is an approach to mining antigen-specific diversity from phage display antibody libraries. Previously, we developed and used this…”
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Microinjection of the oncogene form of the human H-ras (T-24) protein results in rapid proliferation of quiescent cells by Feramisco, J R, Gross, M, Kamata, T, Rosenberg, M, Sweet, R W

“…Using an E. coli expression-vector system we have efficiently produced, purified, and characterized the full-length, nonfused, protooncogenic and oncogenic…”
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The product of ras is a GTPase and the T24 oncogenic mutant is deficient in this activity by Sweet, Raymond W, Yokoyama, Shiro, Kamata, Tohru, Feramisco, James R, Rosenberg, Martin, Gross, Mitchell

“…Ha-ras is a member of a multigene family in man which encode highly related proteins of 189 amino acids (p21). In vitro, ras proteins bind GTP, and p21 mutants…”
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