Search Results - "Sweep, C. G. J."

Regulation of TRIB3 mRNA and protein in breast cancer by Wennemers, Marloes, Bussink, Johan, van den Beucken, Twan, Sweep, Fred C G J, Span, Paul N

“…Tribbles homolog 3 (TRIB3) is a scaffold protein activated under hypoxic conditions and involved in several cell survival and proliferation pathways. Recently,…”
Get full text

Association between High Levels of Blood Macrophage Migration Inhibitory Factor, Inappropriate Adrenal Response, and Early Death in Patients with Severe Sepsis by Emonts, Marieke, Sweep, Fred C. G. J., Grebenchtchikov, Nicolai, Geurts-Moespot, Anneke, Knaup, Marlies, Chanson, Anne Laure, Erard, Veronique, Renner, Pascal, Hermans, Peter W. M., Hazelzet, Jan A., Calandra, Thierry

“…Background.Identification of new therapeutic targets remains an imperative goal to improve the morbidity and mortality associated with severe sepsis and septic…”
Get full text

Production of 11-Oxygenated Androgens by Testicular Adrenal Rest Tumors by Schröder, Mariska A M, Turcu, Adina F, O'Day, Patrick, van Herwaarden, Antonius E, Span, Paul N, Auchus, Richard J, Sweep, Fred C G J, Claahsen-van der Grinten, Hedi L

“…Testicular adrenal rest tumors (TART) are a common complication in males with classic 21-hydroxylase deficiency (21OHD). TART are likely to contribute to the…”
Get full text

Localization of breast cancer resistance protein (Bcrp) in endocrine organs and inhibition of its transport activity by steroid hormones by Dankers, Anita C. A, Sweep, Fred C. G. J, Pertijs, Jeanne C. L. M, Verweij, Vivienne, van den Heuvel, Jeroen J. M. W, Koenderink, Jan B, Russel, Frans G. M, Masereeuw, Rosalinde

“…Breast cancer resistance protein (BCRP) is known for its protective function against the toxic effects of exogenous compounds. In addition to this, a role in…”
Get full text

Phosphoserine aminotransferase 1 is associated to poor outcome on tamoxifen therapy in recurrent breast cancer by De Marchi, Tommaso, Timmermans, Mieke A., Sieuwerts, Anieta M., Smid, Marcel, Look, Maxime P., Grebenchtchikov, Nicolai, Sweep, Fred C. G. J., Smits, Jan G., Magdolen, Viktor, van Deurzen, Carolien H. M., Foekens, John A., Umar, Arzu, Martens, John W.

“…In a previous study, we detected a significant association between phosphoserine aminotransferase 1 (PSAT1) hyper-methylation and mRNA levels to outcome to…”
Get full text

Meta-GWAS and Meta-Analysis of Exome Array Studies Do Not Reveal Genetic Determinants of Serum Hepcidin by Galesloot, Tessel E, Verweij, Niek, Traglia, Michela, Barbieri, Caterina, van Dijk, Freerk, Geurts-Moespot, Anneke J, Girelli, Domenico, Kiemeney, Lambertus A L M, Sweep, Fred C G J, Swertz, Morris A, van der Meer, Peter, Camaschella, Clara, Toniolo, Daniela, Vermeulen, Sita H, van der Harst, Pim, Swinkels, Dorine W

“…Serum hepcidin concentration is regulated by iron status, inflammation, erythropoiesis and numerous other factors, but underlying processes are incompletely…”
Get full text

Regulation of cytokine responses by seasonality of vitamin D status in healthy individuals by Khoo, A.-L, Chai, L.Y.A, Koenen, H.J.P.M, Sweep, F.C.G.J, Joosten, I, Netea, M.G, van der Ven, A.J.A.M

“…The immune modulating capacity of vitamin D₃ is well-recognized. Ultra-violet (UV) exposure determines production of vitamin D₃in vivo and varies through the…”
Get full text

Liver afferents contribute to water drinking-induced sympathetic activation in human subjects: a clinical trial by May, Marcus, Gueler, Faikah, Barg-Hock, Hannelore, Heiringhoff, Karl-Heinz, Engeli, Stefan, Heusser, Karsten, Diedrich, André, Brandt, André, Strassburg, Christian P, Tank, Jens, Sweep, Fred C G J, Jordan, Jens

“…Water drinking acutely increases sympathetic activity in human subjects. In animals, the response appears to be mediated through transient receptor potential…”
Get full text

Bilateral Testicular Tumors Resulting in Recurrent Cushing Disease After Bilateral Adrenalectomy by Puar, Troy, Engels, Manon, van Herwaarden, Antonius E, Sweep, Fred C. G J, Hulsbergen-van de Kaa, Christina, Kamphuis-van Ulzen, Karin, Chortis, Vasileios, Arlt, Wiebke, Stikkelbroeck, Nike, Claahsen-van der Grinten, Hedi L, Hermus, Ad R. M M

“…CONTEXT:Recurrence of hypercortisolism in patients after bilateral adrenalectomy for Cushing disease is extremely rare. PATIENT:We present a 27-year-old man…”
Get full text

Hypoxic regulation and prognostic value of LAMP3 expression in breast cancer by Nagelkerke, Anika, Mujcic, Hilda, Bussink, Johan, Wouters, Bradly G., van Laarhoven, Hanneke W. M., Sweep, Fred C. G. J., Span, Paul N.

“…BACKGROUND: LAMP3 is a newly described hypoxia regulated gene of potential interest in hypoxia‐induced therapy resistance and metastasis. The prognostic value…”
Get full text

Dipeptidyl-Peptidase-IV Inhibition Augments Postprandial Lipid Mobilization and Oxidation in Type 2 Diabetic Patients by Boschmann, Michael, Engeli, Stefan, Dobberstein, Kerstin, Budziarek, Petra, Strauss, Anke, Boehnke, Jana, Sweep, Fred C. G. J., Luft, Friedrich C., He, YanLing, Foley, James E., Jordan, Jens

“…Context: Dipeptidyl-peptidase-IV (DPP-4) inhibition increases endogenous GLP-1 activity, resulting in improved glycemic control in patients with type 2…”
Get full text

Downregulation of serine protease HTRA1 is associated with poor survival in breast cancer by Lehner, Anna, Magdolen, Viktor, Schuster, Tibor, Kotzsch, Matthias, Kiechle, Marion, Meindl, Alfons, Sweep, Fred C G J, Span, Paul N, Gross, Eva

“…HTRA1 is a highly conserved serine protease which has been implicated in suppression of epithelial-to-mesenchymal-transition (EMT) and cell motility in breast…”
Get full text

Molecular Characterization of Testicular Adrenal Rest Tumors in Congenital Adrenal Hyperplasia: Lesions With Both Adrenocortical and Leydig Cell Features by Smeets, Evelien E. J. W, Span, Paul N, van Herwaarden, Antonius E, Wevers, Ron A, Hermus, Ad R. M. M, Sweep, Fred C. G. J, Claahsen-van der Grinten, Hedi L

“…Context: Testicular adrenal rest tumors (TART) are one of the major long term complications in patients with congenital adrenal hyperplasia. Although several…”
Get full text

Adjuvant Docetaxel in Node-Negative Breast Cancer Patients: A Randomized Trial of AGO-Breast Study Group, German Breast Group, and EORTC-Pathobiology Group by Thomssen, Christoph, Vetter, Martina, Kantelhardt, Eva J, Meisner, Christoph, Schmidt, Marcus, Martin, Pierre M, Clatot, Florian, Augustin, Doris, Hanf, Volker, Paepke, Daniela, Meinerz, Wolfgang, Hoffmann, Gerald, Wiest, Wolfgang, Sweep, Fred C G J, Schmitt, Manfred, Jänicke, Fritz, Loibl, Sibylle, Minckwitz, Gunter von, Harbeck, Nadia

“…In node-negative breast cancer (NNBC), a high risk of recurrence is determined by clinico-pathological or tumor-biological assessment. Taxanes may improve…”
Get full text

Adrenal Steroid Metabolites Accumulating in Congenital Adrenal Hyperplasia Lead to Transactivation of the Glucocorticoid Receptor by Pijnenburg-Kleizen, K. J, Engels, M, Mooij, C. F, Griffin, A, Krone, N, Span, P. N, van Herwaarden, A. E, Sweep, F. C. G. J, Claahsen-van der Grinten, H. L

“…Patients with congenital adrenal hyperplasia (CAH) are often clinically less severely affected by cortisol deficiency than anticipated from their enzymatic…”
Get full text

Bilateral thoracoscopic splanchnicectomy for pain in patients with chronic pancreatitis impairs adrenomedullary but not noradrenergic sympathetic function by Buscher, H. C. J. L., Lenders, J. W. M., Wilder-Smith, O. H. G., Sweep, C. G. J., van Goor, H.

“…Background Bilateral thoracoscopic splanchnicectomy (BTS) is a well-known technique to alleviate intractable pain in patients with chronic pancreatitis. BTS…”
Get full text

Randomized Adjuvant Chemotherapy Trial in High-Risk, Lymph Node-Negative Breast Cancer Patients Identified by Urokinase-Type Plasminogen Activator and Plasminogen Activator Inhibitor Type 1 by Jänicke, Fritz, Prechtl, Anita, Thomssen, Christoph, Harbeck, Nadia, Meisner, Christoph, Untch, Michael, Sweep, C. G. J. Fred, Selbmann, Hans-Konrad, Graeff, Henner, Schmitt, Manfred

“…Background: Most patients with lymph node-negative breast cancer are cured by locoregional treatment; however, about 30% relapse. Because traditional…”
Get full text

Tamoxifen induces radioresistance through NRF2-mediated metabolic reprogramming in breast cancer by Reinema, F V, Sweep, F C G J, Adema, G J, Peeters, W J M, Martens, J W M, Bussink, J, Span, P N

“…Recently, we reported that tamoxifen-resistant (TAM-R) breast cancer cells are cross-resistant to irradiation. Here, we investigated the mechanisms associated…”
Get full text

Diffusion-weighted MR imaging in liver metastases of colorectal cancer: reproducibility and biological validation by Heijmen, Linda, ter Voert, Edwin E. G. W., Nagtegaal, Iris D., Span, Paul, Bussink, Johan, Punt, Cornelis J. A., de Wilt, Johannes H. W., Sweep, Fred C. G. J., Heerschap, Arend, van Laarhoven, Hanneke W. M.

“…Objectives Before diffusion-weighted imaging (DWI) can be implemented in standard clinical practice for response monitoring, data on reproducibility are needed…”
Get full text

Ten-year analysis of the prospective multicentre Chemo-N0 trial validates American Society of Clinical Oncology (ASCO)-recommended biomarkers uPA and PAI-1 for therapy decision making in node-negative breast cancer patients by Harbeck, N, Schmitt, M, Meisner, C, Friedel, C, Untch, M, Schmidt, M, Sweep, C.G.J, Lisboa, B.W, Lux, M.P, Beck, T, Hasmüller, S, Kiechle, M, Jänicke, F, Thomssen, C

“…Abstract Aim Final 10-year analysis of the prospective randomised Chemo-N0 trial is presented. Based on the Chemo-N0 interim results and an European…”
Get full text