Search Results - "Sweeney, William E"

Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease by Zhou, Xia, Fan, Lucy X, Sweeney, Jr, William E, Denu, John M, Avner, Ellis D, Li, Xiaogang

“…Autosomal-dominant polycystic kidney disease (ADPKD) is caused by mutations in either PKD1 or PKD2 and is characterized by the development of multiple…”
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HDAC6 regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation in renal epithelial cells by Liu, Wei, Fan, Lucy X, Zhou, Xia, Sweeney, Jr, William E, Avner, Ellis D, Li, Xiaogang

“…We present for the first time that histone deacetylase 6 (HDAC6) regulates EGFR degradation and trafficking along microtubules in Pkd1 mutant renal epithelial…”
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Src Inhibition Ameliorates Polycystic Kidney Disease by SWEENEY, William E, VON VIGIER, Rodo O, FROST, Philip, AVNER, Ellis D

“…Despite identification of the genes responsible for autosomal dominant polycystic kidney disease (PKD) and autosomal recessive PKD (ARPKD), the precise…”
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Molecular and cellular pathophysiology of autosomal recessive polycystic kidney disease (ARPKD) by Sweeney, Jr, William E, Avner, Ellis D

“…Autosomal recessive polycystic kidney disease (ARPKD) belongs to a group of congenital hepatorenal fibrocystic syndromes characterized by dual renal and…”
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Pathophysiology of childhood polycystic kidney diseases: new insights into disease-specific therapy by Sweeney, William E., Avner, Ellis D.

“…Autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive polycystic kidney disease (ARPKD) are significant causes of morbidity and…”
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G-protein signaling modulator 1 deficiency accelerates cystic disease in an orthologous mouse model of autosomal dominant polycystic kidney disease by Kwon, Michelle, Pavlov, Tengis S., Nozu, Kandai, Rasmussen, Shauna A., Ilatovskaya, Daria V., Lerch-Gaggl, Alexandra, North, Lauren M., Kim, Hyunho, Qian, Feng, Sweeney, William E., Avner, Ellis D., Blumer, Joe B., Staruschenko, Alexander, Park, Frank

“…Polycystic kidney diseases are the most common genetic diseases that affect the kidney. There remains a paucity of information regarding mechanisms by which G…”
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Smac-Mimetic―Induced Epithelial Cell Death Reduces the Growth of Renal Cysts by FAN, Lucy X, XIA ZHOU, SWEENEY, William E, WALLACE, Darren P, AVNER, Ellis D, GRANTHAM, Jared J, XIAOGANG

“…Past efforts to pharmacologically disrupt the development and growth of renal cystic lesions focused primarily on normalizing the activity of a specific…”
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Loss of activator of G‐protein signaling 3 impairs renal tubular regeneration following acute kidney injury in rodents by Regner, Kevin R., Nozu, Kandai, Lanier, Stephen M., Blumer, Joe B., Avner, Ellis D., Sweeney, William E., Park, Frank

“…The intracellular mechanisms underlying renal tubular epithelial cell proliferation and tubular repair following ischemia‐reperfusion injury (IRI) remain…”
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Diagnosis and management of childhood polycystic kidney disease by Sweeney, William E., Avner, Ellis D.

“…A number of syndromic disorders have renal cysts as a component of their phenotypes. These disorders can generally be distinguished from autosomal dominant…”
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Activator of G Protein Signaling 3 Promotes Epithelial Cell Proliferation in PKD by NADELLA, Rama, BLUMER, Joe B, LANIER, Stephen M, PARK, Frank, GUANGFU JIA, KWON, Michelle, AKBULUT, Talha, FENG QIAN, SEDLIC, Filip, WAKATSUKI, Tetsuro, SWEENEY, William E, WILSON, Patricia D

“…The activation of heterotrimeric G protein signaling is a key feature in the pathophysiology of polycystic kidney diseases (PKD). In this study, we report…”
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Role of genetic modifiers in an orthologous rat model of ARPKD by O'Meara, Caitlin C, Hoffman, Matthew, Sweeney, Jr, William E, Tsaih, Shirng-Wern, Xiao, Bing, Jacob, Howard J, Avner, Ellis D, Moreno, Carol

“…Human data and animal models of autosomal recessive polycystic kidney disease (ARPKD) suggest that genetic factors modulate the onset and severity of the…”
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20-HETE Mediates Proliferation of Renal Epithelial Cells in Polycystic Kidney Disease by PARK, Frank, SWEENEY, William E, GUANGFU JIA, ROMAN, Richard J, AVNER, Ellis D

“…Polycystic kidney diseases are characterized by abnormal proliferation of renal epithelial cells. In this study, the role of 20-hydroxyeicosatetraenoic acid…”
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Emerging Therapies for Childhood Polycystic Kidney Disease by Sweeney, Jr, William E, Avner, Ellis D

“…Cystic kidney diseases comprise a varied collection of hereditary disorders, where renal cysts comprise a major element of their pleiotropic phenotype. In…”
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EGF receptor tyrosine kinase inhibition attenuates the development of PKD in Han:SPRD rats by Torres, Vicente E., Sweeney, William E., Wang, Xiaofang, Qian, Qi, Harris, Peter C., Frost, Philip, Avner, Ellis D.

“…EGF receptor tyrosine kinase inhibition attenuates the development of PKD in the Han:SPRD rats. Increasing evidence supports an important role for the…”
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Chronic blockade of 20-HETE synthesis reduces polycystic kidney disease in an orthologous rat model of ARPKD by Park, Frank, Sweeney, Jr, William E, Jia, Guangfu, Akbulut, Talha, Mueller, Benjamin, Falck, J Russell, Birudaraju, Saritha, Roman, Richard J, Avner, Ellis D

“…20-Hydroxyeicosatetraenoic acid (20-HETE) has been implicated as a potential mediator in epithelial cell proliferation and cyst formation in polycystic kidney…”
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EGF-related growth factors in the pathogenesis of murine ARPKD by DELL, Katherine Macrae, NEMO, Raghad, SWEENEY, William E, AVNER, Ellis D

“…Epidermal growth factor (EGF), transforming growth factor-alpha (TGF-alpha) and their receptor, EGFR, play key roles in polycystic kidney disease (PKD)…”
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Transport, cilia, and PKD: must we in (cyst) on interrelationships? Focus on "Increased Na+/H+ exchanger activity on the apical surface of a cilium-deficient cortical collecting duct principal cell model of polycystic kidney disease" by Avner, Ellis D, McDonough, Alicia A, Sweeney, Jr, William E

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Epidermal growth factor receptor tyrosine kinase inhibition is not protective in PCK rats by Torres, Vicente E., Sweeney, William E., Wang, Xiaofang, Qian, Qi, Harris, Peter C., Frost, Philip, Avner, Ellis D.

“…Epidermal growth factor receptor tyrosine kinase inhibition is not protective in PCK rats. Advances in the understanding of cystogenesis, identification of the…”
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Renal Cystic Disease: New Insights for the Clinician by Avner, Ellis D., Sweeney, William E.

“…This article cannot comprehensively cover the enormous strides made in defining the molecular and cellular basis of renal cystic diseases over the last decade…”
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Combination treatment of PKD utilizing dual inhibition of EGF-receptor activity and ligand bioavailability by Sweeney, William E., Hamahira, Kiyoshi, Sweeney, Jennifer, Garcia-Gatrell, Michelle, Frost, Philip, Avner, Ellis D.

“…Combination treatment of PKD utilizing dual inhibition of EGF-receptor activity and ligand bioavailability. We have previously demonstrated an essential role…”
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