Search Results - "Sweeney, Lee"

How Myosin Generates Force on Actin Filaments by Houdusse, Anne, Sweeney, H. Lee

“…How myosin interacts with actin to generate force is a subject of considerable controversy. The major debate centers on understanding at what point in force…”
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Motor Proteins by Sweeney, H Lee, Holzbaur, Erika L F

“…Myosin motors power movements on actin filaments, whereas dynein and kinesin motors power movements on microtubules. The mechanisms of these motor proteins…”
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Force Generation by Myosin Motors: A Structural Perspective by Robert-Paganin, Julien, Pylypenko, Olena, Kikuti, Carlos, Sweeney, H. Lee, Houdusse, Anne

“…Generating force and movement is essential for the functions of cells and organisms. A variety of molecular motors that can move on tracks within cells have…”
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High-resolution structures of the actomyosin-V complex in three nucleotide states provide insights into the force generation mechanism by Pospich, Sabrina, Sweeney, H Lee, Houdusse, Anne, Raunser, Stefan

“…The molecular motor myosin undergoes a series of major structural transitions during its force-producing motor cycle. The underlying mechanism and its coupling…”
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The Nuclear Receptor PPARγ Controls Progressive Macrophage Polarization as a Ligand-Insensitive Epigenomic Ratchet of Transcriptional Memory by Daniel, Bence, Nagy, Gergely, Czimmerer, Zsolt, Horvath, Attila, Hammers, David W., Cuaranta-Monroy, Ixchelt, Poliska, Szilard, Tzerpos, Petros, Kolostyak, Zsuzsanna, Hays, Tristan T., Patsalos, Andreas, Houtman, René, Sauer, Sascha, Francois-Deleuze, Jean, Rastinejad, Fraydoon, Balint, Balint L., Sweeney, H. Lee, Nagy, Laszlo

“…Macrophages polarize into distinct phenotypes in response to complex environmental cues. We found that the nuclear receptor PPARγ drove robust phenotypic…”
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Altered Smooth Muscle Cell Force Generation as a Driver of Thoracic Aortic Aneurysms and Dissections by Milewicz, Dianna M, Trybus, Kathleen M, Guo, Dong-chuan, Sweeney, H Lee, Regalado, Ellen, Kamm, Kristine, Stull, James T

“…The importance of maintaining contractile function in aortic smooth muscle cells (SMCs) is evident by the fact that heterozygous mutations in the major…”
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Matrix Elasticity Directs Stem Cell Lineage Specification by Engler, Adam J., Sen, Shamik, Sweeney, H. Lee, Discher, Dennis E.

“…Microenvironments appear important in stem cell lineage specification but can be difficult to adequately characterize or control with soft tissues. Naive…”
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How Actin Initiates the Motor Activity of Myosin by Llinas, Paola, Isabet, Tatiana, Song, Lin, Ropars, Virginie, Zong, Bin, Benisty, Hannah, Sirigu, Serena, Morris, Carl, Kikuti, Carlos, Safer, Dan, Sweeney, H. Lee, Houdusse, Anne

“…Fundamental to cellular processes are directional movements driven by molecular motors. A common theme for these and other molecular machines driven by ATP is…”
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The D2.mdx mouse as a preclinical model of the skeletal muscle pathology associated with Duchenne muscular dystrophy by Hammers, David W., Hart, Cora C., Matheny, Michael K., Wright, Lillian A., Armellini, Megan, Barton, Elisabeth R., Sweeney, H. Lee

“…Duchenne muscular dystrophy (DMD) is an X-linked, lethal muscle degenerative disease caused by loss of dystrophin protein. DMD has no cure and few treatment…”
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Large-scale serum protein biomarker discovery in Duchenne muscular dystrophy by Hathout, Yetrib, Brody, Edward, Clemens, Paula R., Cripe, Linda, DeLisle, Robert Kirk, Furlong, Pat, Gordish-Dressman, Heather, Hache, Lauren, Henricson, Erik, Hoffman, Eric P., Kobayashi, Yvonne Monique, Lorts, Angela, Mah, Jean K., McDonald, Craig, Mehler, Bob, Nelson, Sally, Nikrad, Malti, Singer, Britta, Steele, Fintan, Sterling, David, Sweeney, H. Lee, Williams, Steve, Gold, Larry

“…Significance Duchenne muscular dystrophy (DMD) is a rare and devastating muscle disease caused by mutations in the X-linked DMD gene (which encodes the…”
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Phase 2a study of ataluren-mediated dystrophin production in patients with nonsense mutation Duchenne muscular dystrophy by Finkel, Richard S, Flanigan, Kevin M, Wong, Brenda, Bönnemann, Carsten, Sampson, Jacinda, Sweeney, H Lee, Reha, Allen, Northcutt, Valerie J, Elfring, Gary, Barth, Jay, Peltz, Stuart W

“…Approximately 13% of boys with Duchenne muscular dystrophy (DMD) have a nonsense mutation in the dystrophin gene, resulting in a premature stop codon in the…”
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The myosin X motor is optimized for movement on actin bundles by Ropars, Virginie, Yang, Zhaohui, Isabet, Tatiana, Blanc, Florian, Zhou, Kaifeng, Lin, Tianming, Liu, Xiaoyan, Hissier, Pascale, Samazan, Frédéric, Amigues, Béatrice, Yang, Eric D., Park, Hyokeun, Pylypenko, Olena, Cecchini, Marco, Sindelar, Charles V., Sweeney, H. Lee, Houdusse, Anne

“…Myosin X has features not found in other myosins. Its structure must underlie its unique ability to generate filopodia, which are essential for neuritogenesis,…”
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Osteopontin ablation ameliorates muscular dystrophy by shifting macrophages to a pro-regenerative phenotype by Capote, Joana, Kramerova, Irina, Martinez, Leonel, Vetrone, Sylvia, Barton, Elisabeth R, Sweeney, H Lee, Miceli, M Carrie, Spencer, Melissa J

“…In the degenerative disease Duchenne muscular dystrophy, inflammatory cells enter muscles in response to repetitive muscle damage. Immune factors are required…”
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Increased collagen cross-linking is a signature of dystrophin-deficient muscle by Smith, Lucas R., Hammers, David W., Sweeney, H. Lee, Barton, Elisabeth R.

“…ABSTRACT Introduction Collagen cross‐linking is a key parameter in extracellular matrix (ECM) maturation, turnover, and stiffness. We examined aspects of…”
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Too much of a good thing by Sweeney, H Lee

“…A mutation that causes heart disease in humans increases the number of active myosin heads during muscle contraction in fruit flies, leading to the progressive…”
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Supraphysiological levels of GDF11 induce striated muscle atrophy by Hammers, David W, Merscham‐Banda, Melissa, Hsiao, Jennifer Ying, Engst, Stefan, Hartman, James J, Sweeney, H Lee

“…Growth and differentiation factor (GDF) 11 is a member of the transforming growth factor β superfamily recently identified as a potential therapeutic for…”
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Rescue of dystrophic skeletal muscle by PGC-1α involves a fast to slow fiber type shift in the mdx mouse by Selsby, Joshua T, Morine, Kevin J, Pendrak, Klara, Barton, Elisabeth R, Sweeney, H Lee

“…Increased utrophin expression is known to reduce pathology in dystrophin-deficient skeletal muscles. Transgenic over-expression of PGC-1α has been shown to…”
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Activin Receptor Type IIB Inhibition Improves Muscle Phenotype and Function in a Mouse Model of Spinal Muscular Atrophy by Liu, Min, Hammers, David W, Barton, Elisabeth R, Sweeney, H Lee

“…Spinal muscular atrophy (SMA) is a devastating neurodegenerative disorder that causes progressive muscle atrophy and weakness. Using adeno-associated…”
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Muscle-Specific Expression of Insulin-Like Growth Factor I Counters Muscle Decline in Mdx Mice by Barton, Elisabeth R., Morris, Linda, Musaro, Antonio, Rosenthal, Nadia, Sweeney, H. Lee

“…Duchenne muscular dystrophy is an X-linked degenerative disorder of muscle caused by the absence of the protein dystrophin. A major consequence of muscular…”
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Activin type II receptor ligand signaling inhibition after experimental ischemic heart failure attenuates cardiac remodeling and prevents fibrosis by Castillero, Estibaliz, Akashi, Hirokazu, Najjar, Marc, Ji, Ruiping, Brandstetter, Lea Maria, Wang, Catherine, Liao, Xianghai, Zhang, Xiaokan, Sperry, Alexandra, Gailes, Marcia, Guaman, Karina, Recht, Adam, Schlosberg, Ira, Sweeney, H Lee, Ali, Ziad A, Homma, Shunichi, Colombo, Paolo C, Ferrari, Giovanni, Schulze, P Christian, George, Isaac

“…Myostatin (MSTN) is a transforming growth factor (TGF)-β superfamily member that acts as a negative regulator of muscle growth and may play a role in cardiac…”
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