Search Results - "Sweeney, Kieron"

Technical note: Novel use of recombinant tissue plasminogen activator for the evacuation of an acute extensive spinal epidural haematoma in a patient with coagulopathy by Koustais, Stavros, Sweeney, Kieron J., Bolger, Ciaran

“…Spontaneous extensive spinal epidural haematoma poses a unique challenge for the neurosurgeon. Performing extensive laminectomies to remove all of the…”
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Nanocomposite formulation for a sustained release of free drug and drug-loaded responsive nanoparticles: an approach for a local therapy of glioblastoma multiforme by Erthal, Luiza C. S., Shi, Yang, Sweeney, Kieron J., Gobbo, Oliviero L., Ruiz-Hernandez, Eduardo

“…Malignant gliomas are a type of primary brain tumour that originates in glial cells. Among them, glioblastoma multiforme (GBM) is the most common and the most…”
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Exoscope aided trans-sulcal minimally invasive parafascicular resection of a paediatric brainstem pilocytic astrocytoma using a tubular retractor system by Sweeney, Kieron J., Amoo, Michael, Kilbride, Ronan, Jallo, George I., Javadpour, Mohsen

“…The surgical management of brainstem glioma is challenging and has significant morbidity. Advances in surgical armamentarium has presented the opportunity to…”
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How I do it: parietal trans-sulcal para-fascicular approach to lateral thalamic/internal capsule cavernous malformation by Amoo, Michael, Sweeney, Kieron J., Kilbride, Ronan, Javadpour, Mohsen

“…Background The surgical management of deep brain lesions is challenging, with significant morbidity. Advances in surgical technology have presented the…”
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A clinically relevant computed tomography (CT) radiomics strategy for intracranial rodent brain tumour monitoring by Connor, Kate, Conroy, Emer, White, Kieron, Shiels, Liam P., Keek, Simon, Ibrahim, Abdalla, Gallagher, William M., Sweeney, Kieron J., Clerkin, James, O’Brien, David, Cryan, Jane B., O’Halloran, Philip J., Heffernan, Josephine, Brett, Francesca, Lambin, Philippe, Woodruff, Henry C., Byrne, Annette T.

“…Here, we establish a CT-radiomics based method for application in invasive, orthotopic rodent brain tumour models. Twenty four NOD/SCID mice were implanted…”
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Pumilio-1 mediated translational control of claudin-5 at the blood-brain barrier by Hashimoto, Yosuke, Greene, Chris, Hanley, Nicole, Hudson, Natalie, Henshall, David, Sweeney, Kieron J, O'Brien, Donncha F, Campbell, Matthew

“…Claudin-5 is one of the most essential tight junction proteins at the blood-brain barrier. A single nucleotide polymorphism rs10314 is located in the…”
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Gross total resection rates of grade II/III intramedullary ependymomas using the surgical strategy of en-bloc resection without intra-operative neurophysiological monitoring by Sweeney, Kieron J., Reynolds, Matt, Farrell, Michael, Bolger, Ciaran

“…Introduction: Grade II and III intramedullary ependymomas [IME] are circumscribed with a plane of cleavage that should facilitate high gross total resection…”
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RET overexpression leads to increased brain metastatic competency in luminal breast cancer by Jagust, Petra, Powell, Aoibhin M, Ola, Mihaela, Watson, Louise, de Pablos-Aragoneses, Ana, García-Gómez, Pedro, Fallon, Ramón, Bane, Fiona, Heiland, Mona, Morris, Gareth, Cavanagh, Brenton, McGrath, Jason, Ottaviani, Daniela, Hegarty, Aisling, Cocchiglia, Sinéad, Sweeney, Kieron J, MacNally, Stephen, Brett, Francesca M, Cryan, Jane, Beausang, Alan, Morris, Patrick, Valiente, Manuel, Hill, Arnold D K, Varešlija, Damir, Young, Leonie S

“…Breast cancer brain metastasis is a rising occurrence, necessitating a better understanding of the mechanisms involved for effective management. Breast cancer…”
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Somatic variants as a cause of drug‐resistant epilepsy including mesial temporal lobe epilepsy with hippocampal sclerosis by Carton, Robert J., Doyle, Michael G., Kearney, Hugh, Steward, Charles A., Lench, Nicholas J., Rogers, Anthony, Heinzen, Erin L., McDonald, Seamus, Fay, Joanna, Lacey, Austin, Beausang, Alan, Cryan, Jane, Brett, Francesca, El‐Naggar, Hany, Widdess‐Walsh, Peter, Costello, Daniel, Kilbride, Ronan, Doherty, Colin P., Sweeney, Kieron J., O'Brien, Donncha F., Henshall, David C., Delanty, Norman, Cavalleri, Gianpiero L., Benson, Katherine A.

“…Objective The contribution of somatic variants to epilepsy has recently been demonstrated, particularly in the etiology of malformations of cortical…”
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Refining Glioblastoma Surgery through the Use of Intra-Operative Fluorescence Imaging Agents by Netufo, Oluwakanyinsolami, Connor, Kate, Shiels, Liam P, Sweeney, Kieron J, Wu, Dan, O'Shea, Donal F, Byrne, Annette T, Miller, Ian S

“…Glioblastoma (GBM) is the most aggressive adult brain tumour with a dismal 2-year survival rate of 26-33%. Maximal safe resection plays a crucial role in…”
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The first case report of medulloblastoma associated with Tatton‐Brown–Rahman syndrome by Sweeney, Kieron J., Mottolese, Carmine, Belot, Alexandre, Szathmari, Alexandru, Frappaz, Didier, Lesca, Gaetan, Putoux, Audrey, Di Rocco, Federico

“…DNMT3A codes for a DNA methyl transferase enzyme that plays a central role embryogenesis. Somatic mutations in this gene have been associated with…”
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Vagus nerve stimulation in refractory idiopathic generalised epilepsy: An Irish retrospective observational study by Peña-Ceballos, Javier, Moloney, Patrick B., Valentin, Antonio, O'Donnell, Cara, Colleran, Niamh, Liggan, Brenda, Staunton-Grufferty, Breege, Ennis, Patricia, Grogan, Roger, Mullins, Gerard, Costello, Daniel J., Doherty, Colin P., Sweeney, Kieron J., El Naggar, Hany, Kilbride, Ronan D., Widdess-Walsh, Peter, O'Brien, Donncha, Delanty, Norman

“…•VNS is a safe and effective treatment option for refractory IGE.•VNS-related side-effects are common but rarely result in treatment discontinuation.•VNS is a…”
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Comparative analysis of deeply phenotyped GBM cohorts of ‘short-term’ and ‘long-term’ survivors by Biswas, Archita, Salvucci, Manuela, Connor, Kate, Düssmann, Heiko, Carberry, Steven, Fichtner, Michael, King, Ellen, Murphy, Brona, O’Farrell, Alice C., Cryan, Jane, Beausang, Alan, Heffernan, Josephine, Cremona, Mattia, Hennessy, Bryan T., Clerkin, James, Sweeney, Kieron J., MacNally, Steve, Brett, Francesca, O’Halloran, Philip, Bacon, Orna, Furney, Simon, Verreault, Maite, Quissac, Emie, Bielle, Franck, Ahmed, Mohammed H., Idbaih, Ahmed, Leenstra, Sieger, Ntafoulis, Ioannis, Fabro, Federica, Lamfers, Martine, Golebiewska, Anna, Hertel, Frank, Niclou, Simone P., Yen, Romain Tching Chi, Kremer, Andreas, Dilcan, Gonca, Lodi, Francesca, Arijs, Ingrid, Lambrechts, Diether, Purushothama, Manasa Kalya, Kel, Alexander, Byrne, Annette T., Prehn, Jochen H.M.

“…Background Glioblastoma (GBM) is an aggressive brain cancer that typically results in death in the first 15 months after diagnosis. There have been limited…”
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Low level myelomeningoceles: do they need prenatal surgery? by Beuriat, Pierre-Aurelien, Poirot, Isabelle, Hameury, Frederic, Demede, Delphine, Sweeney, Kieron J., Szathmari, Alexandru, Di Rocco, Federico, Mottolese, Carmine

“…Background Postnatal closure of a myelomeningocele remains the standard of care in many countries. The prenatal closure has given hope for decreasing the…”
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High-resolution multimodal profiling of human epileptic brain activity via explanted depth electrodes by Dwivedi, Anuj Kumar, Mahesh, Arun, Sanfeliu, Albert, Larkin, Julian, Siwicki, Rebecca A., Sweeney, Kieron J., O'Brien, Donncha F., Widdess-Walsh, Peter, Picelli, Simone, Henshall, David C., Tiwari, Vijay K.

“…The availability and integration of electrophysiological and molecular data from the living brain is critical to understand and diagnose complex human disease…”
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Targeting the RhoGEF βPIX/COOL-1 in Glioblastoma: Proof of Concept Studies by Connor, Kate, Murray, David W, Jarzabek, Monika A, Tran, Nhan L, White, Kieron, Dicker, Patrick, Sweeney, Kieron J, O'Halloran, Philip J, MacCarthy, Brian, Shiels, Liam P, Lodi, Francesca, Lambrechts, Diether, Sarkaria, Jann N, Schiffelers, Raymond M, Symons, Marc, Byrne, Annette T

“…Glioblastoma (GBM), a highly invasive and vascular malignancy is shown to rapidly develop resistance and evolve to a more invasive phenotype following…”
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Validation of an imageable surgical resection animal model of Glioblastoma (GBM) by Sweeney, Kieron J., Jarzabek, Monika A., Dicker, Patrick, O’Brien, Donncha F., Callanan, John J., Byrne, Annette T., Prehn, Jochen H.M.

“…•Description of a novel cranial defect repair technique in the pre-clinical setting.•Rat GBM surgical resection model mimics post resection GBM recurrence in…”
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A Neurosurgery for Intractable Epilepsy in Pregnancy: A Case Report by Behan, Claire, Hynes, Sinead, Ennis, Patricia, Ibrahim Khalil, Mohamed, Hogan, Jennifer, Brett, Francesca, Sweeney, Kieron, Kilbride, Ronan, Doherty, Colin P

“…•Case report a pregnant woman with acute deterioration of seizure control despite increased ASM doses.•Rapid care was facilitated by advanced nurse…”
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Molecular imaging in the development of a novel treatment paradigm for glioblastoma (GBM): an integrated multidisciplinary commentary by Jarzabek, Monika A., Sweeney, Kieron J., Evans, Rhys L., Jacobs, Andreas H., Stupp, Roger, O’Brien, Donncha, Berger, Mitchel S., Prehn, Jochen H.M., Byrne, Annette T.

“…•Molecular imaging (MI) plays a key part in identifying glioblastoma (GBM) therapies against multiple cancer hallmarks.•Functional magnetic resonance imaging…”
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Spinal level of myelomeningocele lesion as a contributing factor in posterior fossa volume, intracranial cerebellar volume, and cerebellar ectopia by Sweeney, Kieron J, Caird, John, Sattar, Muhammad Taufiq, Allcutt, David, Crimmins, Darach

“…McLone and Knepper's unified theory of Chiari malformation Type II (CM-II) describes how the loss of CSF via the open posterior neuropore fails to create…”
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