Search Results - "Sweeney, Joseph B."

Catalytic C−C Bond Formation Using a Simple Nickel Precatalyst System: Base‐ and Activator‐Free Direct C‐Allylation by Alcohols and Amines by Sweeney, Joseph B., Ball, Anthony K., Smith, Luke J.

“…A “totally catalytic” nickel(0)‐mediated method for base‐free direct alkylation of allyl alcohols and allyl amines is reported. The reaction is selective for…”
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A Robust First-Pass Protocol for the Heck–Mizoroki Reaction by Murray, Paul M, Bower, John F, Cox, David K, Galbraith, Ewan K, Parker, Jeremy S, Sweeney, Joseph B

“…The Heck–Mizoroki (HM) reaction is one of the most widely used C–C bond-forming methods of contemporary synthesis. Notwithstanding this, these reactions…”
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Synthesis of 3-Substituted Pyrrolidines via Palladium-Catalyzed Hydroarylation by Sweeney, Joseph B, Doulcet, Julien, Thapa, Bimod

“…Metal-catalyzed reactions have revolutionized synthetic chemistry, allowing access to unprecedented molecular architectures with powerful properties and…”
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Catalytic sp3–sp3 Functionalisation of Sulfonamides: Late‐Stage Modification of Drug‐Like Molecules by Abdulla, Othman, Clayton, Adam D., Faulkner, Robert A., Gill, Duncan M., Rice, Craig R., Walton, Scarlett M., Sweeney, Joseph B.

“…A new application of Pd‐catalysed allylation is reported that enables the synthesis of a range of branched sp3‐functionalised sulfonamides, a compound class…”
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Improving the specificity of E. coli acetate/propionate exclusion biosensors via iterative engineering by Sweeney, Joseph B., McDonnell, Kevin, Murphy, Cormac D.

“…Real-time monitoring of key performance indicator analytes such as acetate and propionate within anaerobic digestors (AD) is required for optimum biogas…”
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Escherichia coli-based biorefining process yields optically pure lactic acid from fermented second-generation feedstocks by Visentin, Anna, Murphy, Cormac D., Alvarado-Morales, Merlin, Angelidaki, Irini, Sweeney, Joseph B.

“…Within the circular bioeconomy the production of optically pure LA from 2nd generation feedstocks would be ideal but it is very challenging. In this paper…”
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C−C Bond Formation by Dual Pyrrolidine and Nickel Catalysis: Allylation of Ketones by Allylic Alcohols by Wright, Noah, Townsend, Bara, Nicholson, Steven, Robinson, Joshua, Akien, Geoffrey, Ball, Anthony K., Sweeney, Joseph B., Doulcet, Julien

“…Whilst catalytic ketone allylation using palladium(0) is well–precedented, nickel(0)‐catalysed equivalents of such reactions remain scarce. We report here the…”
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A Simple, Broad‐Scope Nickel(0) Precatalyst System for the Direct Amination of Allyl Alcohols by Sweeney, Joseph B., Ball, Anthony K., Lawrence, Philippa A., Sinclair, Mackenzie C., Smith, Luke J.

“…The preparation of allylic amines is traditionally accomplished by reactions of amines with reactive electrophiles, such as allylic halides, sulfonates, or…”
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Tandem Aryne‐Capture/Sigmatropic Rearrangement as a Metal‐Free Entry to Functionalized N‐Aryl Pyrrolidines by Moss, Sam G., Pocock, Ian A., Sweeney, Joseph B.

“…We report a new method for the synthesis of novel N‐aryl proline analogues. By reacting an aryne precursor with N‐(2‐malonyl) tetrahydropyridines in the…”
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Development of a bacterial propionate-biosensor for anaerobic digestion monitoring by Sweeney, Joseph B., Murphy, Cormac D., McDonnell, Kevin

“…•A previously designed acetate biosensor, E. coli IMD Wldgy, was used as a starting point for further development as a propionate biosensor.•Knock-out of acs…”
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Optimizing the Mizoroki–Heck reaction of cyclic allyl amines: Gram-scale synthesis of preclamol without protecting groups by Sweeney, Joseph B., Adams, Kirsty, Doulcet, Julien, Thapa, Bimod, Tran, Fanny, Crook, Robert

“…[Display omitted] •Improved Mizoroki–Heck cross coupling of tetrahydropyridines is reported.•The improved process allows the use of non-precious-metal…”
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Microfluidic-Based Bacterial Molecular Computing on a Chip by Martins, Daniel P., Barros, Michael Taynnan, O'Sullivan, Benjamin J., Seymour, Ian, O'Riordan, Alan, Coffey, Lee, Sweeney, Joseph B., Balasubramaniam, Sasitharan

“…Biocomputing systems based on engineered bacteria can lead to novel tools for environmental monitoring and detection of metabolic diseases. In this paper, we…”
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Parallel Kinetic Resolution of Intramolecular Furan Diels‐Alder Cycloadducts via Asymmetric Hydroboration by Fulgheri, Tamara, Cornwall, Philip, Turner, Andrew R., Sweeney, Joseph B., Gill, Duncan M.

“…We report parallel kinetic resolution of intramolecular Diels‐Alder cycloadducts, where up to five stereocentres are defined using asymmetric hydroboration as…”
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Riluzole–Triazole Hybrids as Novel Chemical Probes for Neuroprotection in Amyotrophic Lateral Sclerosis by Sweeney, Joseph B, Rattray, Marcus, Pugh, Victoria, Powell, Lucy A

“…Despite intense attention from biomedical and chemical researchers, there are few approved treatments for amyotrophic lateral sclerosis (ALS), with only…”
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An iron-catalysed C–C bond-forming spirocyclization cascade providing sustainable access to new 3D heterocyclic frameworks by Adams, Kirsty, Ball, Anthony K., Birkett, James, Brown, Lee, Chappell, Ben, Gill, Duncan M., Lo, P. K. Tony, Patmore, Nathan J., Rice, Craig. R., Ryan, James, Raubo, Piotr, Sweeney, Joseph B.

“…Heterocyclic architectures offer powerful creative possibilities to a range of chemistry end-users. This is particularly true of heterocycles containing a high…”
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First Efficient and General Copper-Catalyzed [2,3]-Rearrangement of Tetrahydropyridinium Ylids by Roberts, Edward, Sançon, Julien P, Sweeney, Joseph B, Workman, James A

“…The factors affecting the copper-catalyzed rearrangement of ammonium ylids derived from tetrahydropyridines and diazoesters have been examined,and the first…”
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Synthesis of a Protected keto-Lysidine Analogue via Improved Preparation of Arabino-isoCytosine Nucleosides by Sweeney, Joseph B, Bethel, Paul A, Gill, Duncan M, Ochocińska, Agata M, Walsh, Anthony E. J, Walton, Scarlett M

“…Anhydrouridines react with aliphatic amines to give N-alkyl isocytosines, but reported procedures often demand very long reaction times and can be low…”
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Reaction Workup Planning: A Structured Flowchart Approach, Exemplified in Difficult Aqueous Workup of Hydrophilic Products by Hill, George B, Sweeney, Joseph B

“…Reaction workup can be a complex problem for those facing novel synthesis of difficult compounds for the first time. Workup problem solving by systematic…”
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Copper(II)-Catalyzed [2,3]-Sigmatropic Rearrangement of N-Methyltetrahydropyridinium Ylids by Heath, Peter, Roberts, Edward, Sweeney, Joseph B, Wessel, Hans Peter, Workman, James A

“…A ring-contractive and highly diastereoselective [2,3]-sigmatropic rearrangement occurs when N-methyl-1,2,3,6-tetrahydropyridine is treated with…”
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Catalytic sp 3 -sp 3 Functionalisation of Sulfonamides: Late-Stage Modification of Drug-Like Molecules by Abdulla, Othman, Clayton, Adam D, Faulkner, Robert A, Gill, Duncan M, Rice, Craig R, Walton, Scarlett M, Sweeney, Joseph B

“…A new application of Pd-catalysed allylation is reported that enables the synthesis of a range of branched sp -functionalised sulfonamides, a compound class…”
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