Search Results - "Sweatt, J. D."

Age-related changes in Arc transcription and DNA methylation within the hippocampus by Penner, M.R, Roth, T.L, Chawla, M.K, Hoang, L.T, Roth, E.D, Lubin, F.D, Sweatt, J.D, Worley, P.F, Barnes, C.A

“…Abstract The transcription of genes that support memory processes are likely to be impacted by the normal aging process. Because Arc is necessary for memory…”
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Protein Kinase C Overactivity Impairs Prefrontal Cortical Regulation of Working Memory by Birnbaum, S. G., Yuan, P. X., Wang, M., Vijayraghavan, S., Bloom, A. K., Davis, D. J., Gobeske, K. T., Sweatt, J. D., Manji, H. K., Arnsten, A. F. T.

“…The prefrontal cortex is a higher brain region that regulates thought, behavior, and emotion using representational knowledge, operations often referred to as…”
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Tet1 Isoforms Differentially Regulate Gene Expression, Synaptic Transmission, and Memory in the Mammalian Brain by Greer, C B, Wright, J, Weiss, J D, Lazarenko, R M, Moran, S P, Zhu, J, Chronister, K S, Jin, A Y, Kennedy, A J, Sweatt, J D, Kaas, G A

“…The dynamic regulation of DNA methylation in postmitotic neurons is necessary for memory formation and other adaptive behaviors. Ten-eleven translocation 1…”
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Presenilin 1 familial Alzheimer's disease mutation leads to defective associative learning and impaired adult neurogenesis by Wang, R, Dineley, K.T, Sweatt, J.D, Zheng, H

“…Alzheimer's disease is a learning and memory disorder pathologically characterized by the deposition of β-amyloid plaques and loss of neurons and synapses in…”
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Activation of ERK/MAP Kinase in the Amygdala Is Required for Memory Consolidation of Pavlovian Fear Conditioning by Schafe, Glenn E, Atkins, Coleen M, Swank, Michael W, Bauer, Elizabeth P, Sweatt, J. David, LeDoux, Joseph E

“…Although much has been learned about the neurobiological mechanisms underlying Pavlovian fear conditioning at the systems and cellular levels, relatively…”
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Toward a molecular explanation for long-term potentiation by Sweatt, J D

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Inhibitory effects of omega-3 fatty acids on protein kinase C activity in vitro by KIM, H. F, WEEBER, E. J, SWEATT, J. D, STOLL, A. L, MARANGELL, L. B

“…Preliminary clinical data indicate that omega-3 fatty acids may be effective mood stabilizers for patients with bipolar disorder. Both lithium and valproic…”
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Epigenetic mechanisms: a common theme in vertebrate and invertebrate memory formation by Levenson, J M, Sweatt, J D

“…In this review we address the idea that conservation of epigenetic mechanisms for information storage represents a unifying model in biology, with epigenetic…”
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Mitogen-activated protein kinases in synaptic plasticity and memory by Sweatt, J David

“…This review highlights five areas of recent discovery concerning the role of extracellular-signal regulated kinases (ERKs) in the hippocampus. First, ERKs have…”
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Kainate mediates nuclear factor-kappa B activation in hippocampus via phosphatidylinositol-3 kinase and extracellular signal-regulated protein kinase by Lubin, F.D., Johnston, L.D., Sweatt, J.D., Anderson, A.E.

“…The transcription factor nuclear factor-kappa B (NF-κB) is an inducible regulator of genes that plays a crucial role in the nervous system. Glutamate receptor…”
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Deletion of ERK2 Mitogen-Activated Protein Kinase Identifies Its Key Roles in Cortical Neurogenesis and Cognitive Function by Samuels, Ivy S, Karlo, J. Colleen, Faruzzi, Alicia N, Pickering, Kathryn, Herrup, Karl, Sweatt, J. David, Saitta, Sulagna C, Landreth, Gary E

“…The mitogen-activated protein (MAP) kinases ERK1 and ERK2 are critical intracellular signaling intermediates; however, little is known about their…”
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N-Methyl-D-Aspartate Receptor Activation Increases cAMP Levels and Voltage-Gated Ca2+Channel Activity in Area CA1 of Hippocampus by Chetkovich, D. M., Gray, R., Johnston, D., Sweatt, J. D.

“…Tetanic stimulation of the Schaffer collateral inputs into area CA1 of the hippocampus causes N-methyl-D-aspartate (NMDA) receptor activation, an effect that…”
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The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory by Sweatt, J. David

“…The mitogen‐activated protein kinase (MAP kinase, MAPK) cascade, as the name implies, was originally discovered as a critical regulator of cell division and…”
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Mechanism of Protein Kinase C Activation During the Induction and Maintenance of Long-Term Potentiation Probed Using a Selective Peptide Substrate by Klann, Eric, Chen, Shu-Jen, Sweatt, J. David

“…Previous reports using various protein kinase inhibitors have suggested that protein kinase activity is necessary for both the induction and maintenance of…”
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Input-specific immunolocalization of differentially phosphorylated Kv4.2 in the mouse brain by Varga, A W, Anderson, A E, Adams, J P, Vogel, H, Sweatt, J D

“…Voltage-gated A-type potassium channels such as Kv4.2 regulate generation of action potentials and are localized abundantly in the hippocampus and striatum…”
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nMDA receptor activation increases cyclic AMP in area CA1 of the hippocampus via calcium/calmodulin stimulation of adenylyl cyclase by Chetkovich, D M, Sweatt, J D

“…We observed previously that activation of N-methyl-D-aspartate (NMDA) receptors in area CA1 of the hippocampus, through either NMDA application or long-term…”
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Roles of serine/threonine phosphatases in hippocampal synaptic plasticity by Winder, D G, Sweatt, J D

“…The regulation of glutamate-mediated excitatory neurotransmission has a critical role in many aspects of behaviour. Great effort has gone into understanding…”
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Molecular psychology: roles for the ERK MAP kinase cascade in memory by Adams, J Paige, Sweatt, J David

“…In this review we describe an emerging understanding of the roles of the Extracellular-signal regulated kinase/mitogen-activated protein kinase (ERK/MAPK)…”
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Persistent protein kinase activation in the maintenance phase of long-term potentiation by KLANN, E, SHU-JEN CHEN, SWEATT, J. D

“…Long-term potentiation (LTP) of synaptic transmission in the hippocampus is a robust form of synaptic plasticity that may contribute to mammalian memory…”
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Evidence that Na+/H+ exchange regulates receptor-mediated phospholipase A2 activation in human platelets by Sweatt, J D, Connolly, T M, Cragoe, E J, Limbird, L E

“…Data in the previous paper suggest that epinephrine can mobilize a small pool of arachidonic acid via an enzymatic pathway distinct from phospholipase C and…”
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