Search Results - "Sweat, Mason E."
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CMYA5 establishes cardiac dyad architecture and positioning
Published in Nature communications (21-04-2022)“…Cardiac excitation-contraction coupling requires dyads, the nanoscopic microdomains formed adjacent to Z-lines by apposition of transverse tubules and…”
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Efficient and reproducible generation of human iPSC-derived cardiomyocytes and cardiac organoids in stirred suspension systems
Published in Nature communications (15-07-2024)“…Human iPSC-derived cardiomyocytes (hiPSC-CMs) have proven invaluable for cardiac disease modeling and regeneration. Challenges with quality, inter-batch…”
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In Vivo Dissection of Chamber-Selective Enhancers Reveals Estrogen-Related Receptor as a Regulator of Ventricular Cardiomyocyte Identity
Published in Circulation (New York, N.Y.) (14-03-2023)“…Cardiac chamber-selective transcriptional programs underpin the structural and functional differences between atrial and ventricular cardiomyocytes (aCMs and…”
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Enhancement of MicroRNA-200c on Osteogenic Differentiation and Bone Regeneration by Targeting Sox2-Mediated Wnt Signaling and Klf4
Published in Human gene therapy (01-11-2019)“…MicroRNA (miR)-200c functions in antitumorigenesis and mediates inflammation and osteogenic differentiation. In this study, we discovered that was upregulated…”
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Antisense Oligonucleotide Therapy for Calmodulinopathy
Published in Circulation (New York, N.Y.) (08-10-2024)“…Calmodulinopathies are rare inherited arrhythmia syndromes caused by dominant heterozygous variants in , , or , which each encode the identical CaM…”
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364-OR: Beta-Cell Glucose-Regulated Micropeptide 1 (BGRM1) Controls Cellular Homeostasis in Pancreatic Beta Cells
Published in Diabetes (New York, N.Y.) (01-06-2019)“…Accumulating evidence demonstrates that certain types of long-noncoding RNAs (lncRNA) encode very short open reading frames, called micropeptides. By…”
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Rat Calvarial Bone Regeneration by 3D-Printed β‑Tricalcium Phosphate Incorporating MicroRNA-200c
Published in ACS biomaterials science & engineering (13-09-2021)“…Advanced fabrication methods for bone grafts designed to match defect sites that combine biodegradable, osteoconductive materials with potent, osteoinductive…”
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A Sox2‐Lef‐1 Protein Interaction Inhibits Lef‐1 Transcriptional Activity and WNT Signaling During Odontogenesis
Published in The FASEB journal (01-04-2017)“…Abstract only Tooth development proceeds through a series of steps wherein epithelial and mesenchymal tissue layers cooperate to form a tooth bud, and cells in…”
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Abstract EC.07: Tbx5 Maintains Atrial Identity By Regulating An Atrial Enhancer Network
Published in Circulation research (04-08-2023)“…Abstract only Atrial cardiomyocytes (aCMs) and ventricular cardiomyocytes (vCMs) are distinct cell types, but the mechanisms underlying these differences are…”
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New in vivo microRNA biotechnology reveals specific roles for the miR‐200 family in dental stem cell maintenance
Published in The FASEB journal (01-04-2019)“…Extracellular signaling as well as transcription factor and epigenetic regulation are well described mechanisms controlling stem cell differentiation. The…”
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New in vivo microRNA biotechnology reveals specific roles for the miR‐200 family in craniofacial development
Published in The FASEB journal (01-04-2018)“…The molecular regulators of stem cell differentiation are a hot topic and the proteins involved in this process have been well studied, but the function of…”
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MicroRNA Mediated Mechanisms of Stem Cell Specification
Published 01-01-2020“…The role of extracellular signaling pathways and transcription factor cascades have been well studied during organogenesis but microRNAs (miRs) remain poorly…”
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Dissertation