Search Results - "Swearingen, Elissa"

RAB18 is a key regulator of GalNAc-conjugated siRNA-induced silencing in Hep3B cells by Lu, Jiamiao, Swearingen, Elissa, Hardy, Miki, Collins, Patrick, Wu, Bin, Yuan, Eric, Lu, Daniel, Li, Chi-Ming, Wang, Songli, Ollmann, Michael

“…Small interfering RNA (siRNA) therapeutics have developed rapidly in recent years, despite the challenges associated with delivery of large, highly charged…”
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Sphingosine kinase activity is not required for tumor cell viability by Rex, Karen, Jeffries, Shawn, Brown, Matthew L, Carlson, Timothy, Coxon, Angela, Fajardo, Flordeliza, Frank, Brendon, Gustin, Darin, Kamb, Alexander, Kassner, Paul D, Li, Shyun, Li, Yihong, Morgenstern, Kurt, Plant, Matthew, Quon, Kim, Ruefli-Brasse, Astrid, Schmidt, Joanna, Swearingen, Elissa, Walker, Nigel, Wang, Zhulun, Watson, J E Vivienne, Wickramasinghe, Dineli, Wong, Mariwil, Xu, Guifen, Wesche, Holger

“…Sphingosine kinases (SPHKs) are enzymes that phosphorylate the lipid sphingosine, leading to the formation of sphingosine-1-phosphate (S1P). In addition to the…”
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Use of cryopreserved cell aliquots in the high-throughput screening of small interfering RNA libraries by Swearingen, Elissa A, Fajardo, Flordeliza, Wang, Xiangyun, Watson, J E Vivienne, Quon, Kim C, Kassner, Paul D

“…Screening small interfering RNA (siRNA) libraries holds the potential to elucidate gene function as well as discover new targets for the therapeutic treatment…”
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Development of a high throughput time-resolved fluorescence resonance energy transfer assay for TRAF6 ubiquitin polymerization by Hong, Catherine A, Swearingen, Elissa, Mallari, Rommel, Gao, Xiong, Cao, Zhaodan, North, Anne, Young, Stephen W, Huang, Shu-Gui

“…Interleukin 1 receptor activation innervates a cascade of signal transduction events that ultimately lead to the activation of inflammatory and immune response…”
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Identification and Optimization of a Minor Allele-Specific siRNA to Prevent PNPLA3 I148M-Driven Nonalcoholic Fatty Liver Disease by Murray, Justin K, Long, Jason, Liu, Lei, Singh, Shivani, Pruitt, Danielle, Ollmann, Michael, Swearingen, Elissa, Hardy, Miki, Homann, Oliver, Wu, Bin, Holder, Jerry Ryan, Sham, Kelvin, Herberich, Brad, Lo, Mei-Chu, Dou, Hui, Shkumatov, Artem, Florio, Monica, Rulifson, Ingrid C

“…Human genome wide association studies confirm the association of the rs738409 single nucleotide polymorphism (SNP) in the gene encoding protein patatin like…”
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Abstract 4548: High throughput siRNA screens uncover a high rate of USP8 and ESCRT pathway dependency in squamous carcinoma cell lines by Zhong, Wendy, Cosgrove, Elissa, Swearingen, Elissa, Ollmann, Mike, Banerjee, Jayee, Watson, Vivienne, Jaeckel, Peter, Pfreimer, Mariana, Materna-Reichelt, Silvia, Beckmann, Holger, Kassner, Paul, Ruefli-Brasse, Astrid, Nolan-Stevaux, Olivier

“…Abstract USP8 and the ESCRT pathway (endosomal sorting complex required for transport) are required for cellular homeostasis through key functions in shuttling…”
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Abstract 2992: Stringent analysis of large-scale siRNA screens identifies a kinase fusion oncogene by Ruefli-Brasse, Astrid A., Hart, Cynthia, Fajardo, Liza, Swearingen, Elissa, Wong, Linda, Sakamoto, Doreen, Hale, Kari, Ge, Huanying, McDowell, Jeffery, Ramachandran, Bharath, Cosgrove, Elissa, Watson, J.E.Vivienne, Ragan, Seamus, Kassner, Paul, Quon, Kim

“…Abstract The interpretation of RNAi knockdown experiments can be challenging due to the extensive off-target effects exhibited by siRNAs and shRNAs. This has…”
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A generic high-throughput screening assay for kinases: protein kinase a as an example by Mallari, Rommel, Swearingen, Elissa, Liu, Wei, Ow, Arnold, Young, Stephen W, Huang, Shu-Gui

“…A generic high-throughput screening assay based on the scintillation proximity assay technology has been developed for protein kinases. In this assay, the…”
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