Search Results - "Swatek, Kirby N"

Ubiquitin modifications by Swatek, Kirby N, Komander, David

“…Protein ubiquitination is a dynamic multifaceted post-translational modification involved in nearly all aspects of eukaryotic biology. Once attached to a…”
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Global Landscape and Dynamics of Parkin and USP30-Dependent Ubiquitylomes in iNeurons during Mitophagic Signaling by Ordureau, Alban, Paulo, Joao A., Zhang, Jiuchun, An, Heeseon, Swatek, Kirby N., Cannon, Joe R., Wan, Qiaoqiao, Komander, David, Harper, J. Wade

“…The ubiquitin ligase Parkin, protein kinase PINK1, USP30 deubiquitylase, and p97 segregase function together to regulate turnover of damaged mitochondria via…”
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Assembly and Specific Recognition of K29- and K33-Linked Polyubiquitin by Michel, Martin A., Elliott, Paul R., Swatek, Kirby N., Simicek, Michal, Pruneda, Jonathan N., Wagstaff, Jane L., Freund, Stefan M.V., Komander, David

“…Protein ubiquitination regulates many cellular processes via attachment of structurally and functionally distinct ubiquitin (Ub) chains. Several atypical chain…”
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Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis by Wauer, Tobias, Swatek, Kirby N, Wagstaff, Jane L, Gladkova, Christina, Pruneda, Jonathan N, Michel, Martin A, Gersch, Malte, Johnson, Christopher M, Freund, Stefan MV, Komander, David

“…The protein kinase PINK1 was recently shown to phosphorylate ubiquitin (Ub) on Ser65, and phosphoUb activates the E3 ligase Parkin allosterically. Here, we…”
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OTULIN deficiency in ORAS causes cell type‐specific LUBAC degradation, dysregulated TNF signalling and cell death by Damgaard, Rune Busk, Elliott, Paul R, Swatek, Kirby N, Maher, Eamonn R, Stepensky, Polina, Elpeleg, Orly, Komander, David, Berkun, Yackov

“…The deubiquitinase OTULIN removes methionine‐1 (M1)‐linked polyubiquitin signals conjugated by the linear ubiquitin chain assembly complex (LUBAC) and is…”
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Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2 by Annibaldi, Alessandro, Wicky John, Sidonie, Vanden Berghe, Tom, Swatek, Kirby N., Ruan, Jianbin, Liccardi, Gianmaria, Bianchi, Katiuscia, Elliott, Paul R., Choi, Sze Men, Van Coillie, Samya, Bertin, John, Wu, Hao, Komander, David, Vandenabeele, Peter, Silke, John, Meier, Pascal

“…Tumor necrosis factor (TNF) can drive inflammation, cell survival, and death. While ubiquitylation-, phosphorylation-, and nuclear factor κB (NF-κB)-dependent…”
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Insights into the ISG15 transfer cascade by the UBE1L activating enzyme by Wallace, Iona, Baek, Kheewoong, Prabu, J. Rajan, Vollrath, Ronnald, von Gronau, Susanne, Schulman, Brenda A., Swatek, Kirby N.

“…The attachment of the ubiquitin-like protein ISG15 to substrates by specific E1-E2-E3 enzymes is a well-established signalling mechanism of the innate immune…”
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Multisite phosphorylation of 14-3-3 proteins by calcium-dependent protein kinases by Swatek, Kirby N, Wilson, Rashaun S, Ahsan, Nagib, Tritz, Rebecca L, Thelen, Jay J

“…Plant 14-3-3 proteins are phosphorylated at multiple sites in vivo; however, the protein kinase(s) responsible are unknown. Of the 34 CPK (calcium-dependent…”
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Regulation of the Regulators: Post-Translational Modifications, Subcellular, and Spatiotemporal Distribution of Plant 14-3-3 Proteins by Wilson, Rashaun S, Swatek, Kirby N, Thelen, Jay J

“…14-3-3 proteins bind to and modulate the activity of phosphorylated proteins that regulate a variety of metabolic processes in eukaryotes. Multiple 14-3-3…”
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A Chlamydia effector combining deubiquitination and acetylation activities induces Golgi fragmentation by Pruneda, Jonathan N., Bastidas, Robert J., Bertsoulaki, Erithelgi, Swatek, Kirby N., Santhanam, Balaji, Clague, Michael J., Valdivia, Raphael H., Urbé, Sylvie, Komander, David

“…Pathogenic bacteria are armed with potent effector proteins that subvert host signalling processes during infection 1 . The activities of bacterial effectors…”
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The 14-3-3 Isoforms Chi and Epsilon Differentially Bind Client Proteins from Developing Arabidopsis Seed by Swatek, Kirby N, Graham, Katherine, Agrawal, Ganesh K, Thelen, Jay J

“…The 14-3-3-protein family is prominently expressed during seed filling and modulates protein interactions and enzymatic activities, in a…”
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Dissecting distinct proteolytic activities of FMDV Lpro implicates cleavage and degradation of RLR signaling proteins, not its deISGylase/DUB activity, in type I interferon suppression by Visser, Linda J, Aloise, Chiara, Swatek, Kirby N, Medina, Gisselle N, Olek, Karin M, Rabouw, Huib H, de Groot, Raoul J, Langereis, Martijn A, de Los Santos, Teresa, Komander, David, Skern, Tim, van Kuppeveld, Frank J M

“…The type I interferon response is an important innate antiviral pathway. Recognition of viral RNA by RIG-I-like receptors (RLRs) activates a signaling cascade…”
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Ubiquitin Linkage-Specific Affimers Reveal Insights into K6-Linked Ubiquitin Signaling by Michel, Martin A., Swatek, Kirby N., Hospenthal, Manuela K., Komander, David

“…Several ubiquitin chain types have remained unstudied, mainly because tools and techniques to detect these posttranslational modifications are scarce…”
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Decoding Arabidopsis thaliana CPK/SnRK Superfamily Kinase Client Signaling Networks Using Peptide Library and Mass Spectrometry by Ahsan, Nagib, Kataya, Amr R A, Rao, R Shyama Prasad, Swatek, Kirby N, Wilson, Rashaun S, Meyer, Louis J, Tovar-Mendez, Alejandro, Stevenson, Severin, Maszkowska, Justyna, Dobrowolska, Grazyna, Yao, Qiuming, Xu, Dong, Thelen, Jay J

“…Members of the calcium-dependent protein kinase (CDPK/CPK) and SNF-related protein kinase (SnRK) superfamilies are commonly found in plants and some protists…”
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Pollen Proteins Bind to the C-terminal Domain of Nicotiana alata Pistil Arabinogalactan Proteins by Lee, Christopher B., Swatek, Kirby N., McClure, Bruce

“…Pollen tube growth is influenced by interaction between pollen proteins and the pistil extracellular matrix. The transmitting tract-specific glycoprotein…”
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A Versatile Mass Spectrometry-Based Method to Both Identify Kinase Client-Relationships and Characterize Signaling Network Topology by Ahsan, Nagib, Huang, Yadong, Tovar-Mendez, Alejandro, Swatek, Kirby N, Zhang, Jingfen, Miernyk, Ján A, Xu, Dong, Thelen, Jay J

“…While more than a thousand protein kinases (PK) have been identified in the Arabidopsis thaliana genome, relatively little progress has been made toward…”
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Insights into ubiquitin chain architecture using Ub-clipping by Swatek, Kirby N., Usher, Joanne L., Kueck, Anja F., Gladkova, Christina, Mevissen, Tycho E. T., Pruneda, Jonathan N., Skern, Tim, Komander, David

“…Protein ubiquitination is a multi-functional post-translational modification that affects all cellular processes. Its versatility arises from architecturally…”
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The Tumour Suppressor TMEM127 Is a Nedd4-Family E3 Ligase Adaptor Required by Salmonella SteD to Ubiquitinate and Degrade MHC Class II Molecules by Alix, Eric, Godlee, Camilla, Cerny, Ondrej, Blundell, Samkeliso, Tocci, Romina, Matthews, Sophie, Liu, Mei, Pruneda, Jonathan N., Swatek, Kirby N., Komander, David, Sleap, Tabitha, Holden, David W.

“…The Salmonella enterica effector SteD depletes mature MHC class II (mMHCII) molecules from the surface of infected antigen-presenting cells through…”
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Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies by Swatek, Kirby N., Aumayr, Martina, Pruneda, Jonathan N., Visser, Linda J., Berryman, Stephen, Kueck, Anja F., Geurink, Paul P., Ovaa, Huib, van Kuppeveld, Frank J. M., Tuthill, Tobias J., Skern, Tim, Komander, David

“…In response to viral infection, cells mount a potent inflammatory response that relies on ISG15 and ubiquitin posttranslational modifications. Many viruses use…”
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Initial description of the developing soybean seed protein Lys-N(ε)-acetylome by Smith-Hammond, Colin L, Swatek, Kirby N, Johnston, Mark L, Thelen, Jay J, Miernyk, Ján A

“…Characterization of the myriad protein posttranslational modifications (PTM) is a key aspect of proteome profiling. While there have been previous studies of…”
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