Search Results - "Swartz, Kenton J"

Physical basis of apparent pore dilation of ATP-activated P2X receptor channels by Li, Mufeng, Toombes, Gilman E S, Silberberg, Shai D, Swartz, Kenton J

“…The prevailing view for purinergic P2X receptor channels is that their ion conduction pores dilate upon prolonged activation. This study finds that the…”
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Heat activation is intrinsic to the pore domain of TRPV1 by Zhang, Feng, Jara-Oseguera, Andres, Chang, Tsg-Hui, Bae, Chanhyung, Hanson, Sonya M., Swartz, Kenton J.

“…The TRPV1 channel is a sensitive detector of pain-producing stimuli, including noxious heat, acid, inflammatory mediators, and vanilloid compounds. Although…”
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Deconstructing voltage sensor function and pharmacology in sodium channels by Swartz, Kenton J, Bosmans, Frank, Martin-Eauclaire, Marie-France

“…Voltage-activated sodium (Na v ) channels are crucial for the generation and propagation of nerve impulses, and as such are widely targeted by toxins and…”
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Structures of the T cell potassium channel Kv1.3 with immunoglobulin modulators by Selvakumar, Purushotham, Fernández-Mariño, Ana I., Khanra, Nandish, He, Changhao, Paquette, Alice J., Wang, Bing, Huang, Ruiqi, Smider, Vaughn V., Rice, William J., Swartz, Kenton J., Meyerson, Joel R.

“…The Kv1.3 potassium channel is expressed abundantly on activated T cells and mediates the cellular immune response. This role has made the channel a target for…”
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Capsaicin Interaction with TRPV1 Channels in a Lipid Bilayer: Molecular Dynamics Simulation by Hanson, Sonya M., Newstead, Simon, Swartz, Kenton J., Sansom, Mark S.P.

“…Transient receptor potential vanilloid subtype 1 (TRPV1) is a heat-sensitive ion channel also involved in pain sensation, and is the receptor for capsaicin,…”
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Ion permeation pathway within the internal pore of P2X receptor channels by Tam, Stephanie W, Huffer, Kate, Li, Mufeng, Swartz, Kenton J

“…P2X receptor channels are trimeric ATP-activated ion channels expressed in neuronal and non-neuronal cells that are attractive therapeutic targets for human…”
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Regulation of membrane homeostasis by TMC1 mechanoelectrical transduction channels is essential for hearing by Ballesteros, Angela, Swartz, Kenton J.

“…The mechanoelectrical transduction (MET) channel in auditory hair cells converts sound into electrical signals, enabling hearing. Transmembrane-like channel 1…”
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The ion selectivity filter is not an activation gate in TRPV1-3 channels by Jara-Oseguera, Andrés, Huffer, Katherine E, Swartz, Kenton J

“…Activation of TRPV1 channels in sensory neurons results in opening of a cation permeation pathway that triggers the sensation of pain. Opening of TRPV1 has…”
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Global alignment and assessment of TRP channel transmembrane domain structures to explore functional mechanisms by Huffer, Katherine E, Aleksandrova, Antoniya A, Jara-Oseguera, Andrés, Forrest, Lucy R, Swartz, Kenton J

“…The recent proliferation of published TRP channel structures provides a foundation for understanding the diverse functional properties of this important family…”
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An external sodium ion binding site controls allosteric gating in TRPV1 channels by Jara-Oseguera, Andres, Bae, Chanhyung, Swartz, Kenton J

“…TRPV1 channels in sensory neurons are integrators of painful stimuli and heat, yet how they integrate diverse stimuli and sense temperature remains elusive…”
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Structural interactions of a voltage sensor toxin with lipid membranes by Mihailescu, Mihaela, Krepkiy, Dmitriy, Milescu, Mirela, Gawrisch, Klaus, Swartz, Kenton J, White, Stephen

“…Protein toxins from tarantula venom alter the activity of diverse ion channel proteins, including voltage, stretch, and ligand-activated cation channels…”
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Subtype-specific control of P2X receptor channel signaling by ATP and Mg2 by Li, Mufeng, Silberberg, Shai D, Swartz, Kenton J

“…The identity and forms of activating ligands for ion channels are fundamental to their physiological roles in rapid electrical signaling. P2X receptor channels…”
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Portability of paddle motif function and pharmacology in voltage sensors by Kim, Jae Il, Jung, Hoi Jong, Swartz, Kenton J, Alabi, AbdulRasheed A, Bahamonde, Maria Isabel

“…Voltage-sensing domains enable membrane proteins to sense and react to changes in membrane voltage. Although identifiable S1-S4 voltage-sensing domains are…”
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Cannabidiol sensitizes TRPV2 channels to activation by 2-APB by Gochman, Aaron, Tan, Xiao-Feng, Bae, Chanhyung, Chen, Helen, Swartz, Kenton J, Jara-Oseguera, Andres

“…The cation-permeable TRPV2 channel is important for cardiac and immune cell function. Cannabidiol (CBD), a non-psychoactive cannabinoid of clinical relevance,…”
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Towards a structural view of gating in potassium channels by Swartz, Kenton J

“…Voltage-activated cation channels have pores that are selective for K(+), Na(+) or Ca(2+). Neurons use these channels to generate and propagate action…”
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Exploring structure-function relationships between TRP and Kv channels by Kalia, Jeet, Swartz, Kenton J.

“…The molecular mechanisms underlying the activation of Transient Receptor Potential (TRP) ion channels are poorly understood when compared to those of the…”
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Pore-opening mechanism in trimeric P2X receptor channels by Li, Mufeng, Swartz, Kenton J, Kawate, Toshimitsu, Silberberg, Shai D

“…The opening of ion channels in response to ligand binding, voltage or membrane stretch underlies electrical and chemical signalling throughout biology. Two…”
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Inter- and intrasubunit interactions between transmembrane helices in the open state of P2X receptor channels by Heymann, Gabriel, Dai, Jian, Li, Mufeng, Silberberg, Shai D, Zhou, Huan-Xiang, Swartz, Kenton J

“…P2X receptor channels open in response to the binding of extracellular ATP, a property that is essential for purinergic sensory signaling. Apo and ATP-bound…”
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Palmitoylation influences the function and pharmacology of sodium channels by Bosmans, Frank, Milescu, Mirela, Swartz, Kenton J

“…Palmitoylation is a common lipid modification known to regulate the functional properties of various proteins and is a vital step in the biosynthesis of…”
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Structural insights into the mechanism of activation of the TRPV1 channel by a membrane-bound tarantula toxin by Bae, Chanhyung, Anselmi, Claudio, Kalia, Jeet, Jara-Oseguera, Andres, Schwieters, Charles D, Krepkiy, Dmitriy, Won Lee, Chul, Kim, Eun-Hee, Kim, Jae Il, Faraldo-Gómez, José D, Swartz, Kenton J

“…Venom toxins are invaluable tools for exploring the structure and mechanisms of ion channels. Here, we solve the structure of double-knot toxin (DkTx), a…”
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