Search Results - "Swartz, Carol D."

Comparison of toxicogenomics and traditional approaches to inform mode of action and points of departure in human health risk assessment of benzo[a]pyrene in drinking water by Moffat, Ivy, Chepelev, Nikolai L., Labib, Sarah, Bourdon-Lacombe, Julie, Kuo, Byron, Buick, Julie K., Lemieux, France, Williams, Andrew, Halappanavar, Sabina, Malik, Amal I, Luijten, Mirjam, Aubrecht, Jiri, Hyduke, Daniel R., Fornace, Albert J., Swartz, Carol D., Recio, Leslie, Yauk, Carole L.

“…Abstract Toxicogenomics is proposed to be a useful tool in human health risk assessment. However, a systematic comparison of traditional risk assessment…”
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Flow cytometric micronucleus assay and TGx-DDI transcriptomic biomarker analysis of ten genotoxic and non-genotoxic chemicals in human HepaRG™ cells by Buick, Julie K, Williams, Andrew, Gagné, Rémi, Swartz, Carol D, Recio, Leslie, Ferguson, Stephen S, Yauk, Carole L

“…Modern testing paradigms seek to apply human-relevant cell culture models and integrate data from multiple test systems to accurately inform potential hazards…”
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Application of the TGx-28.65 transcriptomic biomarker to classify genotoxic and non-genotoxic chemicals in human TK6 cells in the presence of rat liver S9 by Yauk, Carole L., Buick, Julie K., Williams, Andrew, Swartz, Carol D., Recio, Leslie, Li, Heng-Hong, Fornace Jr, Albert J., Thomson, Errol M., Aubrecht, Jiri

“…In vitro transcriptional signatures that predict toxicities can facilitate chemical screening. We previously developed a transcriptomic biomarker (known as…”
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A Modern Genotoxicity Testing Paradigm: Integration of the High-Throughput CometChip® and the TGx-DDI Transcriptomic Biomarker in Human HepaRG™ Cell Cultures by Buick, Julie K., Williams, Andrew, Meier, Matthew J., Swartz, Carol D., Recio, Leslie, Gagné, Rémi, Ferguson, Stephen S., Engelward, Bevin P., Yauk, Carole L.

“…Higher-throughput, mode-of-action-based assays provide a valuable approach to expedite chemical evaluation for human health risk assessment. In this study, we…”
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A predictive toxicogenomics signature to classify genotoxic versus non-genotoxic chemicals in human TK6 cells by Williams, Andrew, Buick, Julie K., Moffat, Ivy, Swartz, Carol D., Recio, Leslie, Hyduke, Daniel R., Li, Heng-Hong, Fornace, Albert J., Aubrecht, Jiri, Yauk, Carole L.

“…Genotoxicity testing is a critical component of chemical assessment. The use of integrated approaches in genetic toxicology, including the incorporation of…”
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Human uterine leiomyoma-derived fibroblasts stimulate uterine leiomyoma cell proliferation and collagen type I production, and activate RTKs and TGF beta receptor signaling in coculture by Moore, Alicia B, Yu, Linda, Swartz, Carol D, Zheng, Xaiolin, Wang, Lu, Castro, Lysandra, Kissling, Grace E, Walmer, David K, Robboy, Stanley J, Dixon, Darlene

“…Uterine leiomyomas (fibroids) are benign smooth muscle tumors that often contain an excessive extracellular matrix (ECM). In the present study, we investigated…”
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Immortalization of Human Uterine Leiomyoma and Myometrial Cell Lines After Induction of Telomerase Activity: Molecular and Phenotypic Characteristics by Carney, Sara A, Tahara, Hidetoshi, Swartz, Carol D, Risinger, John I, He, Hong, Moore, Alicia B, Haseman, Joseph K, Barrett, J Carl, Dixon, Darlene

“…In vitro model systems for studying uterine leiomyomas are limited in that human-derived leiomyoma cells grow poorly in culture compared with normal myometrial…”
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Early microRNA responses in rodent liver mediated by furan exposure establish dose thresholds for later adverse outcomes by Nelson, Gail, Carswell, Gleta, Swartz, Carol, Recio, Les, Yauk, Carole, Chorley, Brian N.

“…To reduce reliance on long-term in vivo studies, short-term data linking early molecular-based measurements to later adverse health effects is needed. Although…”
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Error-corrected duplex sequencing enables direct detection and quantification of mutations in human TK6 cells with strong inter-laboratory consistency by Cho, Eunnara, Swartz, Carol D., Williams, Andrew, V. Rivas, Miriam, Recio, Leslie, Witt, Kristine L., Schmidt, Elizabeth K., Yaplee, Jeffry, Smith, Thomas H., Van, Phu, Lo, Fang Yin, Valentine, Charles C., Salk, Jesse J., Marchetti, Francesco, Smith-Roe, Stephanie L., Yauk, Carole L.

“…Error-corrected duplex sequencing (DS) enables direct quantification of low-frequency mutations and offers tremendous potential for chemical mutagenicity…”
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Evaluation of the herbicide glyphosate, (aminomethyl)phosphonic acid, and glyphosate‐based formulations for genotoxic activity using in vitro assays by Smith‐Roe, Stephanie L., Swartz, Carol D., Rashid, Asma, Christy, Nicholas C., Sly, Jamie E., Chang, Xiaoqing, Sipes, Nisha S., Shockley, Keith R., Harris, Shawn F., McBride, Sandra J., Larson, Gary J., Collins, Bradley J., Mutlu, Esra, Witt, Kristine L.

“…Glyphosate, the most heavily used herbicide world‐wide, is applied to plants in complex formulations that promote absorption. The National Toxicology Program…”
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Toxicogenomic analysis incorporating operon-transcriptional coupling and toxicant concentration-expression response: analysis of MX-treated Salmonella by Ward, William O, Swartz, Carol D, Porwollik, Steffen, Warren, Sarah H, Hanley, Nancy M, Knapp, Geremy W, McClelland, Michael, DeMarini, David M

“…Deficiencies in microarray technology cause unwanted variation in the hybridization signal, obscuring the true measurements of intracellular transcript levels…”
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Integration of metabolic activation with a predictive toxicogenomics signature to classify genotoxic versus nongenotoxic chemicals in human TK6 cells by Buick, Julie K., Moffat, Ivy, Williams, Andrew, Swartz, Carol D., Recio, Leslie, Hyduke, Daniel R., Li, Heng-Hong, Fornace Jr, Albert J., Aubrecht, Jiri, Yauk, Carole L.

“…The use of integrated approaches in genetic toxicology, including the incorporation of gene expression data to determine the molecular pathways involved in the…”
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Integrated in silico and in vitro genotoxicity assessment of thirteen data-poor substances by Tran, Yen K., Buick, Julie K., Keir, Jennifer L.A., Williams, Andrew, Swartz, Carol D., Recio, Leslie, White, Paul A., Lambert, Iain B., Yauk, Carole L.

“…The Canadian Domestic Substances List (DSL) contains chemicals that have not been tested for genotoxicity as their use pre-dates regulatory requirements. In…”
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Using the HepaCometChip Assay for Broad-Spectrum DNA Damage Analysis by Owiti, Norah A, Kaushal, Simran, Martin, Lincoln, Sly, Jamie, Swartz, Carol D, Fowler, Jasmine, Corrigan, Joshua J, Recio, Les, Engelward, Bevin P

“…Exposure to DNA damaging agents can lead to mutations that cause cancer. The liver is particularly vulnerable because it contains high levels of Cytochrome…”
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Black cohosh extracts and powders induce micronuclei, a biomarker of genetic damage, in human cells by Smith‐Roe, Stephanie L., Swartz, Carol D., Shepard, Kim G., Bryce, Steven M., Dertinger, Stephen D., Waidyanatha, Suramya, Kissling, Grace E., Auerbach, Scott S., Witt, Kristine L., Zeiger, E.

“…Black cohosh extract (BCE) is a widely used dietary supplement marketed to women to alleviate symptoms of gynecological ailments, yet its toxicity has not been…”
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Differential expression of receptor tyrosine kinases (RTKs) and IGF-I pathway activation in human uterine leiomyomas by Yu, Linda, Saile, Katrin, Swartz, Carol D, He, Hong, Zheng, Xiaolin, Kissling, Grace E, Di, Xudong, Lucas, Shantelle, Robboy, Stanley J, Dixon, Darlene

“…Uterine leiomyomas (fibroids) are benign tumors that are prevalent in women of reproductive age. Research suggests that activated receptor tyrosine kinases…”
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Integration of the TGx-28.65 genomic biomarker with the flow cytometry micronucleus test to assess the genotoxicity of disperse orange and 1,2,4-benzenetriol in human TK6 cells by Buick, Julie K, Williams, Andrew, Kuo, Byron, Wills, John W, Swartz, Carol D, Recio, Leslie, Li, Heng-Hong, Fornace, Jr, Albert J, Aubrecht, Jiri, Yauk, Carole L

“…In vitro gene expression signatures to predict toxicological responses can provide mechanistic context for regulatory testing. We previously developed the…”
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Mutagenicity, stable DNA adducts, and abasic sites induced in Salmonella by phenanthro[3,4-b]- and phenanthro[4,3-b]thiophenes, sulfur analogs of benzo[c]phenanthrene by Swartz, Carol D, King, Leon C, Nesnow, Stephen, Umbach, David M, Kumar, Subodh, Sikka, Harish, Demarini, David M

“…Sulfur-containing polycyclic aromatic hydrocarbons (thia-PAHs or thiaarenes) are common constituents of air pollution and cigarette smoke, but only a few have…”
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Association of Race, Age and Body Mass Index with Gross Pathology of Uterine Fibroids by MOORE, Alicia B, FLAKE, Gordon P, SWARTZ, Carol D, HEARTWELL, Glenn, COUSINS, Deborah, HASEMAN, Joseph K, KISSLING, Grace E, SIDAWY, Mary K, DIXON, Darlene

“…To determine the associations of race, age and body mass index (BMI) with the gross pathology parameters of uterine leiomyomas in premenopausal women…”
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Mutagen structure and transcriptional response: Induction of distinct transcriptional profiles in Salmonella TA100 by the drinking-water mutagen MX and its homologues by Ward, William O, Swartz, Carol D, Hanley, Nancy M, Whitaker, John W, Franzén, Robert, DeMarini, David M

“…The relationship between chemical structure and biological activity has been examined for various compounds and endpoints for decades. To explore this question…”
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