Search Results - "Swarr, Daniel"

Lung Endoderm Morphogenesis: Gasping for Form and Function by Swarr, Daniel T, Morrisey, Edward E

“…The respiratory endoderm develops from a small cluster of cells located on the ventral anterior foregut. This population of progenitors generates the myriad…”
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Beyond diagnostic yield: prenatal exome sequencing results in maternal, neonatal, and familial clinical management changes by Tolusso, Leandra K., Hazelton, Paige, Wong, Beatrix, Swarr, Daniel T.

“…Purpose Previous studies have reported that prenatal exome sequencing (pES) can detect monogenic diseases in fetuses with congenital anomalies with diagnostic…”
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Perinatal Outcomes of Fetuses and Infants Diagnosed with Trisomy 13 or Trisomy 18 by Cortezzo, DonnaMaria E., Tolusso, Leandra K., Swarr, Daniel T.

“…To identify factors associated with prenatal, perinatal, and postnatal outcomes, and determine medical care use for fetuses and infants with trisomy 13 (T13)…”
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Long noncoding RNAs are spatially correlated with transcription factors and regulate lung development by Herriges, Michael J, Swarr, Daniel T, Morley, Michael P, Rathi, Komal S, Peng, Tien, Stewart, Kathleen M, Morrisey, Edward E

“…Long noncoding RNAs (lncRNAs) are thought to play important roles in regulating gene transcription, but few have well-defined expression patterns or known…”
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Detection and impact of genetic disease in a level IV neonatal intensive care unit by Hagen, Leanne, Khattar, Divya, Whitehead, Katie, He, Hua, Swarr, Daniel T., Suhrie, Kristen

“…Objective To determine detection rates of genetic disease in a level IV neonatal intensive care unit (NICU) and cost of care. Study design We divided 2703…”
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PRDM3/16 regulate chromatin accessibility required for NKX2-1 mediated alveolar epithelial differentiation and function by He, Hua, Bell, Sheila M., Davis, Ashley Kuenzi, Zhao, Shuyang, Sridharan, Anusha, Na, Cheng-Lun, Guo, Minzhe, Xu, Yan, Snowball, John, Swarr, Daniel T., Zacharias, William J., Whitsett, Jeffrey A.

“…While the critical role of NKX2-1 and its transcriptional targets in lung morphogenesis and pulmonary epithelial cell differentiation is increasingly known,…”
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Making a Genetic Diagnosis in a Level IV Neonatal Intensive Care Unit Population: Who, When, How, and at What Cost? by Swaggart, Kayleigh A., Swarr, Daniel T., Tolusso, Leandra K., He, Hua, Dawson, D. Brian, Suhrie, Kristen R.

“…To investigate the prevalence of genetic disease and its economic impact in a level IV neonatal intensive care unit (NICU) by identifying and describing…”
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Systematic Review and Meta-analysis: Gene Association Studies in Neonatal Sepsis by Srinivasan, Lakshmi, Swarr, Daniel T, Sharma, Megha, Cotten, C Michael, Kirpalani, Haresh

“…Association studies of various gene variants in neonatal sepsis show conflicting results.  We performed a systematic review of candidate gene association…”
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The long noncoding RNA Falcor regulates Foxa2 expression to maintain lung epithelial homeostasis and promote regeneration by Swarr, Daniel T, Herriges, Michael, Li, Shanru, Morley, Mike, Fernandes, Sharlene, Sridharan, Anusha, Zhou, Su, Garcia, Benjamin A, Stewart, Kathleen, Morrisey, Edward E

“…Transcription factors (TFs) are dosage-sensitive master regulators of gene expression, with haploinsufficiency frequently leading to life-threatening disease…”
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Twin‐twin transfusion syndrome recipient with arterial calcification and heterozygous variant in ABCC6: Evidence of a gene‐environment interaction? by Springman, Andrea, Forde, Braxton, Tolusso, Leandra, DeFranco, Emily, Swarr, Daniel T., Wright, E. Deah, Habli, Mounira

“…We report a case of a twin‐twin transfusion syndrome (TTTS) recipient who, after successful fetoscopic surgery, developed a large pericardial effusion and…”
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Alveolar epithelial progenitor cells require Nkx2-1 to maintain progenitor-specific epigenomic state during lung homeostasis and regeneration by Toth, Andrea, Kannan, Paranthaman, Snowball, John, Kofron, Matthew, Wayman, Joseph A., Bridges, James P., Miraldi, Emily R., Swarr, Daniel, Zacharias, William J.

“…Lung epithelial regeneration after acute injury requires coordination cellular coordination to pattern the morphologically complex alveolar gas exchange…”
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Novel Molecular and Phenotypic Insights into Congenital Lung Malformations by Swarr, Daniel T, Peranteau, William H, Pogoriler, Jennifer, Frank, David B, Adzick, N Scott, Hedrick, Holly L, Morley, Mike, Zhou, Su, Morrisey, Edward E

“…Disruption of normal pulmonary development is a leading cause of morbidity and mortality in infants. Congenital lung malformations are a unique model to study…”
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Fate of the Residual Distal and Proximal Aorta After Acute Type A Dissection Repair Using a Contemporary Surgical Reconstruction Algorithm by Geirsson, Arnar, MD, Bavaria, Joseph E., MD, Swarr, Daniel, BS, Keane, Martin G., MD, Woo, Y. Joseph, MD, Szeto, Wilson Y., MD, Pochettino, Alberto, MD

“…Background In this study, we evaluated the long-term results of our contemporary, standardized surgical management algorithm for repair of acute type A aortic…”
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PI3K signaling specifies proximal-distal fate by driving a developmental gene regulatory network in SOX9+ mouse lung progenitors by Khattar, Divya, Fernandes, Sharlene, Snowball, John, Guo, Minzhe, Gillen, Matthew C, Jain, Suchi Singh, Sinner, Debora, Zacharias, William, Swarr, Daniel T

“…The tips of the developing respiratory buds are home to important progenitor cells marked by the expression of SOX9 and ID2. Early in embryonic development…”
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P294: Exploring episignatures as a potential diagnostic tool for diabetic embryopathy by Schwan, Ava, Jackson, Farrah, Swarr, Daniel, Russell, David, Slavotinek, Anne

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Preterm infant with diprosopus and holoprosencephaly by Nair, Nitya M., Swarr, Daniel T., Barnes‐Davis, Maria E.

“…Diprosopus is an extremely rare congenital anomaly involving craniofacial duplication. The etiology and pathophysiology remain unknown, and no genetic…”
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Accelerating Scientific Advancement for Pediatric Rare Lung Disease Research. Report from a National Institutes of Health-NHLBI Workshop, September 3 and 4, 2015 by Young, Lisa R, Trapnell, Bruce C, Mandl, Kenneth D, Swarr, Daniel T, Wambach, Jennifer A, Blaisdell, Carol J

“…Pediatric rare lung disease (PRLD) is a term that refers to a heterogeneous group of rare disorders in children. In recent years, this field has experienced…”
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Clinical features of three girls with mosaic genome-wide paternal uniparental isodisomy by Kalish, Jennifer M., Conlin, Laura K., Bhatti, Tricia R., Dubbs, Holly A., Harris, Mary Catherine, Izumi, Kosuke, Mostoufi-Moab, Sogol, Mulchandani, Surabhi, Saitta, Sulagna, States, Lisa J., Swarr, Daniel T., Wilkens, Alisha B., Zackai, Elaine H., Zelley, Kristin, Bartolomei, Marisa S., Nichols, Kim E., Palladino, Andrew A., Spinner, Nancy B., Deardorff, Matthew A.

“…Here we describe three subjects with mosaic genome‐wide paternal uniparental isodisomy (GWpUPD) each of whom presented initially with overgrowth,…”
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Fetal maturation revealed by amniotic fluid cell-free transcriptome in rhesus macaques by Schmidt, Augusto F, Schnell, Daniel J, Eaton, Kenneth P, Chetal, Kashish, Kannan, Paranthaman S, Miller, Lisa A, Chougnet, Claire A, Swarr, Daniel T, Jobe, Alan H, Salomonis, Nathan, Kamath-Rayne, Beena D

“…Accurate estimate of fetal maturity could provide individualized guidance for delivery of complicated pregnancies. However, current methods are invasive, have…”
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Novel FREM1 mutations expand the phenotypic spectrum associated with manitoba-oculo-tricho-anal (MOTA) syndrome and bifid nose renal agenesis anorectal malformations (BNAR) syndrome by Nathanson, Jared, Swarr, Daniel T., Singer, Amihood, Liu, Mochi, Chinn, Amy, Jones, Wendy, Hurst, Jane, Khalek, Nahla, Zackai, Elaine, Slavotinek, Anne

“…Loss of function mutations in FREM1 have been demonstrated in Manitoba‐oculo‐tricho‐anal (MOTA) syndrome and Bifid Nose Renal Agenesis and Anorectal…”
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