Search Results - "Swanson, Patrick"

V(D)J Recombination: Mechanisms of Initiation by Schatz, David G, Swanson, Patrick C

“…V(D)J recombination assembles immunoglobulin and T cell receptor genes during lymphocyte development through a series of carefully orchestrated DNA breakage…”
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The CRL4VPRBP(DCAF1) E3 ubiquitin ligase directs constitutive RAG1 degradation in a non-lymphoid cell line by Schabla, N. Max, Swanson, Patrick C.

“…The development of B and T lymphocytes critically depends on RAG1/2 endonuclease activity to mediate antigen receptor gene assembly by V(D)J recombination…”
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Vitamin C promotes maturation of T-cells by Manning, Jared, Mitchell, Birgitta, Appadurai, Daniel A, Shakya, Arvind, Pierce, Laura Jean, Wang, Hongfang, Nganga, Vincent, Swanson, Patrick C, May, James M, Tantin, Dean, Spangrude, Gerald J

“…Vitamin C (ascorbic acid) is thought to enhance immune function, but the mechanisms involved are obscure. We utilized an in vitro model of T-cell maturation to…”
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DCAF1 (VprBP): emerging physiological roles for a unique dual-service E3 ubiquitin ligase substrate receptor by Schabla, N Max, Mondal, Koushik, Swanson, Patrick C

“…Abstract Cullin-RING ligases (CRLs) comprise a large group of modular eukaryotic E3 ubiquitin ligases. Within this family, the CRL4 ligase (consisting of the…”
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Cryptosporidium uses CSpV1 to activate host type I interferon and attenuate antiparasitic defenses by Deng, Silu, He, Wei, Gong, Ai-Yu, Li, Min, Wang, Yang, Xia, Zijie, Zhang, Xin-Tiang, Huang Pacheco, Andrew S., Naqib, Ankur, Jenkins, Mark, Swanson, Patrick C., Drescher, Kristen M., Strauss-Soukup, Juliane K., Belshan, Michael, Chen, Xian-Ming

“…Cryptosporidium infects gastrointestinal epithelium and is a leading cause of infectious diarrhea and diarrheal-related death in children worldwide. There are…”
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Restorative recreation: One landowner's experience restoring a cedar‐infested native prairie remnant in Iowa's Loess Hills by Swanson, Patrick C.

“…Over 80% of pre‐settlement Iowa was a prairie landscape, but conversion and neglect has reduced that to less than 0.1% of the original 30 million acres (12…”
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A long noncoding RNA, lincRNA‐Tnfaip3, acts as a coregulator of NF‐κB to modulate inflammatory gene transcription in mouse macrophages by Ma, Shibin, Ming, Zhenping, Gong, Ai-Yu, Wang, Yang, Chen, Xiqiang, Hu, Guoku, Zhou, Rui, Shibata, Annemarie, Swanson, Patrick C., Chen, Xian-Ming

“…ABSTRACT Long intergenic noncoding RNAs (lincRNAs) are long noncoding transcripts (>200 nt) from the intergenic regions of annotated protein‐coding genes. We…”
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VprBP (DCAF1): a promiscuous substrate recognition subunit that incorporates into both RING-family CRL4 and HECT-family EDD/UBR5 E3 ubiquitin ligases by Nakagawa, Tadashi, Mondal, Koushik, Swanson, Patrick C

“…The terminal step in the ubiquitin modification system relies on an E3 ubiquitin ligase to facilitate transfer of ubiquitin to a protein substrate. The…”
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Receptor editing constrains development of phosphatidyl choline-specific B cells in VH12-transgenic mice by Worth, Alexandra N., Palmer, Victoria L., Schabla, N. Max, Perry, Greg A., Fraser-Philbin, Anna N., Swanson, Patrick C.

“…B1 B cells reactive to phosphatidyl choline (PtC) exhibit restricted immunoglobulin heavy chain (HC) and light chain (LC) combinations, exemplified by…”
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VprBP (DCAF1) Regulates RAG1 Expression Independently of Dicer by Mediating RAG1 Degradation by Schabla, N Max, Perry, Greg A, Palmer, Victoria L, Swanson, Patrick C

“…The assembly of Ig genes in developing B lymphocytes by V(D)J recombination is initiated by the RAG1-RAG2 endonuclease complex. We previously identified an…”
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V(D)J Recombinase Binding and Cleavage of Cryptic Recombination Signal Sequences Identified from Lymphoid Malignancies by Zhang, Ming, Swanson, Patrick C.

“…V(D)J recombination is a process integral to lymphocyte development. However, this process is not always benign, since certain lymphoid malignancies exhibit…”
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The bounty of RAGs: recombination signal complexes and reaction outcomes by Swanson, Patrick C.

“…V(D)J recombination is a form of site‐specific DNA rearrangement through which antigen receptor genes are assembled. This process involves the breakage and…”
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Real-time monitoring of RAG-catalyzed DNA cleavage unveils dynamic changes in coding end association with the coding end complex by Wang, Guannan, Dhar, Kajari, Swanson, Patrick C, Levitus, Marcia, Chang, Yung

“…During V(D)J recombination, the RAG1/2 recombinase is thought to play an active role in transferring newly excised recombination ends from the RAG…”
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A non-B-DNA structure at the Bcl-2 major breakpoint region is cleaved by the RAG complex by Lieber, Michael R, Raghavan, Sathees C, Swanson, Patrick C, Wu, Xiantuo, Hsieh, Chih-Lin

“…The causes of spontaneous chromosomal translocations in somatic cells of biological organisms are largely unknown, although double-strand DNA breaks are…”
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VprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelity by Kassmeier, Michele D, Mondal, Koushik, Palmer, Victoria L, Raval, Prafulla, Kumar, Sushil, Perry, Greg A, Anderson, Dirk K, Ciborowski, Pawel, Jackson, Sarah, Xiong, Yue, Swanson, Patrick C

“…The N‐terminus of full‐length RAG1, though dispensable for RAG1/2 cleavage activity, is required for efficient V(D)J recombination. This region supports RING…”
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IL10 restrains autoreactive B cells in transgenic mice expressing inactive RAG1 by Palmer, Victoria L., Worth, Alexandra N., Scott, Robyn L., Perry, Greg A., Yan, Mei, Li, Quan-Zhen, Swanson, Patrick C.

“…•Transgenic mice expressing inactive RAG1 (dnRAG1 mice) develop autoreactive B cells.•In vitro differentiation of B cell subsets in dnRAG1 mice are distinctly…”
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Promoter Hypomethylation and Expression Is Conserved in Mouse Chronic Lymphocytic Leukemia Induced by Decreased or Inactivated Dnmt3a by Haney, Staci L., Upchurch, G. Michael, Opavska, Jana, Klinkebiel, David, Hlady, Ryan A., Suresh, Abhinav, Pirruccello, Samuel J., Shukla, Vipul, Lu, Runqing, Costinean, Stefan, Rizzino, Angie, Karpf, Adam R., Joshi, Shantaram, Swanson, Patrick, Opavsky, Rene

“…DNA methyltransferase 3a (DNMT3A) catalyzes the formation of 5-methyl-cytosine in mammalian genomic DNA, and it is frequently mutated in human hematologic…”
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Evidence for Ku70/Ku80 association with full-length RAG1 by Raval, Prafulla, Kriatchko, Aleksei N, Kumar, Sushil, Swanson, Patrick C

“…Antigen receptor genes are assembled by a site-specific DNA rearrangement process called V(D)J recombination. This process proceeds through two distinct…”
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VprBP Is Required for Efficient Editing and Selection of Igκ+ B Cells, but Is Dispensable for Igλ+ and Marginal Zone B Cell Maturation and Selection by Palmer, Victoria L, Aziz-Seible, Razia, Kassmeier, Michele D, Rothermund, Mary, Perry, Greg A, Swanson, Patrick C

“…B cell development past the pro-B cell stage in mice requires the Cul4-Roc1-DDB1 E3 ubiquitin ligase substrate recognition subunit VprBP. Enforced Bcl2…”
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Mechanistic Basis for RAG Discrimination between Recombination Sites and the Off-Target Sites of Human Lymphomas by Shimazaki, Noriko, Askary, Amjad, Swanson, Patrick C., Lieber, Michael R.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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