Search Results - "Swanson, J. M."

Dopamine in drug abuse and addiction: results from imaging studies and treatment implications by VOLKOW, N. D, FOWLER, J. S, WANG, G.-J, SWANSON, J. M

“…The involvement of dopamine in drug reinforcement is well recognized but its role in drug addiction is much less clear. Imaging studies have shown that the…”
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Multiscale simulation reveals a multifaceted mechanism of proton permeation through the influenza A M2 proton channel by Liang, Ruibin, Li, Hui, Swanson, Jessica M. J., Voth, Gregory A.

“…The influenza A virus M2 channel (AM2) is crucial in the viral life cycle. Despite many previous experimental and computational studies, the mechanism of the…”
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Molecular transport through membranes: Accurate permeability coefficients from multidimensional potentials of mean force and local diffusion constants by Sun, Rui, Han, Yining, Swanson, Jessica M J, Tan, Jeffrey S, Rose, John P, Voth, Gregory A

“…Estimating the permeability coefficient of small molecules through lipid bilayer membranes plays an important role in the development of effective drug…”
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Motivation deficit in ADHD is associated with dysfunction of the dopamine reward pathway by Volkow, N D, Wang, G-J, Newcorn, J H, Kollins, S H, Wigal, T L, Telang, F, Fowler, J S, Goldstein, R Z, Klein, N, Logan, J, Wong, C, Swanson, J M

“…Attention-deficit hyperactivity disorder (ADHD) is typically characterized as a disorder of inattention and hyperactivity/impulsivity but there is increasing…”
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Role of Charge Transfer in the Structure and Dynamics of the Hydrated Proton by Swanson, Jessica M. J, Simons, Jack

“…Although it has long been recognized that multiple water molecules strongly associate with an extra proton in bulk water, some models and conceptual frameworks…”
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Capturing the Liquid-Crystalline Phase Transformation: Implications for Protein Targeting to Sterol Ester-Rich Lipid Droplets by Braun, R Jay, Swanson, Jessica M J

“…Lipid droplets are essential organelles that store and traffic neutral lipids. The phospholipid monolayer surrounding their neutral lipid core engages with a…”
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Membrane perturbing properties of toxin mycolactone from Mycobacterium ulcerans by López, Cesar A, Unkefer, Clifford J, Swanson, Basil I, Swanson, Jessica M J, Gnanakaran, S

“…Mycolactone is the exotoxin produced by Mycobacterium ulcerans and is the virulence factor behind the neglected tropical disease Buruli ulcer. The toxin has a…”
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Mycolactone A vs. B: Multiscale Simulations Reveal the Roles of Localization and Association in Isomer-Specific Toxicity by Nguyen, John D M, da Hora, Gabriel C A, Swanson, Jessica M J

“…Mycolactone is an exotoxin produced by that causes the neglected tropical skin disease Buruli ulcer. This toxin inhibits the Sec61 translocon in the…”
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Benchmark Study of the SCC-DFTB Approach for a Biomolecular Proton Channel by Liang, Ruibin, Swanson, Jessica M. J, Voth, Gregory A

“…The self-consistent charge density functional tight binding (SCC-DFTB) method has been increasingly applied to study proton transport (PT) in biological…”
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The Genetic Architecture of Selection at the Human Dopamine Receptor D4 ( DRD4) Gene Locus by Wang, E., Ding, Y.-C., Flodman, P., Kidd, J.R., Kidd, K.K., Grady, D.L., Ryder, O.A., Spence, M.A., Swanson, J.M., Moyzis, R.K.

“…Associations of the seven-repeat (7R) allele of the human dopamine receptor D4 ( DRD4) gene with both the personality trait of novelty seeking and attention…”
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Intricate Role of Water in Proton Transport through Cytochrome c Oxidase by Lee, Hyun Ju, Svahn, Emelie, Swanson, Jessica M. J, Lepp, Håkan, Voth, Gregory A, Brzezinski, Peter, Gennis, Robert B

“…Cytochrome c oxidase (CytcO), the final electron acceptor in the respiratory chain, catalyzes the reduction of O2 to H2O while simultaneously pumping protons…”
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Proton movement and coupling in the POT family of peptide transporters by Parker, Joanne L., Li, Chenghan, Brinth, Allete, Wang, Zhi, Vogeley, Lutz, Solcan, Nicolae, Ledderboge-Vucinic, Gregory, Swanson, Jessica M. J., Caffrey, Martin, Voth, Gregory A., Newstead, Simon

“…POT transporters represent an evolutionarily well-conserved family of proton-coupled transport systems in biology. An unusual feature of the family is their…”
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Dynamic Protonation Dramatically Affects the Membrane Permeability of Drug-like Molecules by Yue, Zhi, Li, Chenghan, Voth, Gregory A, Swanson, Jessica M. J

“…Permeability (P m) across biological membranes is of fundamental importance and a key factor in drug absorption, distribution, and development. Although the…”
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Attention-deficit hyperactivity disorder and hyperkinetic disorder by Swanson, JM, Sergeant, JA, Taylor, E, Sonuga-Barke, EJS, Jensen, PS, Cantwell, DP

“…Swanson et al discuss the diagnosis, epidemiology, treatment, prognosis and pathophysiology of attention-deficit hyperactivity disorder and hyperkinetic…”
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Serum and brain concentrations of methylphenidate: implications for use and abuse by Swanson, J.M, Volkow, N.D

“…When used to treat children with Attention Deficit Hyperactivity Disorder, methylphenidate (MPH) acts primarily by blocking the dopamine (DA) transporter (DAT)…”
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Understanding and Tracking the Excess Proton in Ab Initio Simulations; Insights from IR Spectra by Li, Chenghan, Swanson, Jessica M. J

“…Proton transport in aqueous media is ubiquitously important in chemical and biological processes. Although ab initio molecular dynamics (AIMD) simulations have…”
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Stressed Lipid Droplets: How Neutral Lipids Relieve Surface Tension and Membrane Expansion Drives Protein Association by Kim, Siyoung, Oh, Myong In, Swanson, Jessica M. J

“…Lipid droplets (LDs) are intracellular storage organelles composed of neutral lipids, such as triacylglycerol (TG), surrounded by a phospholipid (PL) monolayer…”
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Dopamine genes and ADHD by Swanson, J.M, Flodman, Pamela, Kennedy, James, Spence, M.Anne, Moyzis, Robert, Schuck, Sabrina, Murias, Michael, Moriarity, Joan, Barr, Cathy, Smith, Moyra, Posner, Michael

“…Family, twin, and adoption studies have documented a strong genetic basis for ADHD/HKD, but these studies do not identify specific genes linked to the…”
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Inactivation of Bacillus anthracis Spores by Liquid Biocides in the Presence of Food Residue by Hilgren, J, Swanson, K.M.J, Diez-Gonzalez, F, Cords, B

“…Biocide inactivation of Bacillus anthracis spores in the presence of food residues after a 10-min treatment time was investigated. Spores of nonvirulent…”
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Pooling/bootstrap-based GWAS (pbGWAS) identifies new loci modifying the age of onset in PSEN1 p.Glu280Ala Alzheimer's disease by Vélez, J I, Chandrasekharappa, S C, Henao, E, Martinez, A F, Harper, U, Jones, M, Solomon, B D, Lopez, L, Garcia, G, Aguirre-Acevedo, D C, Acosta-Baena, N, Correa, J C, Lopera-Gómez, C M, Jaramillo-Elorza, M C, Rivera, D, Kosik, K S, Schork, N J, Swanson, J M, Lopera, F, Arcos-Burgos, M

“…The literature on GWAS (genome-wide association studies) data suggests that very large sample sizes (for example, 50,000 cases and 50,000 controls) may be…”
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