Search Results - "Swanson, Charles M."

Jumping translocations of 1q12 in multiple myeloma: a novel mechanism for deletion of 17p in cytogenetically defined high-risk disease by Sawyer, Jeffrey R., Tian, Erming, Heuck, Christoph J., Epstein, Joshua, Johann, Donald J., Swanson, Charles M., Lukacs, Janet L., Johnson, Marian, Binz, Regina, Boast, Angela, Sammartino, Gael, Usmani, Saad, Zangari, Maurizio, Waheed, Sarah, van Rhee, Frits, Barlogie, Bart

“…Multiple myeloma (MM) is a B-cell malignancy driven in part by increasing copy number alterations (CNAs) during disease progression. Prognostically significant…”
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Evidence of an epigenetic origin for high-risk 1q21 copy number aberrations in multiple myeloma by Sawyer, Jeffrey R., Tian, Erming, Heuck, Christoph J., Johann, Donald J., Epstein, Joshua, Swanson, Charles M., Lukacs, Janet L., Binz, Regina Lichti, Johnson, Marian, Sammartino, Gael, Zangari, Maurizio, Davies, Faith E., van Rhee, Frits, Morgan, Gareth J., Barlogie, Bart

“…Multiple myeloma is a B-cell malignancy stratified in part by cytogenetic abnormalities, including the high-risk copy number aberrations (CNAs) of +1q21 and…”
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Multicolour spectral karyotyping identifies new translocations and a recurring pathway for chromosome loss in multiple myeloma by Sawyer, Jeffrey R., Lukacs, Janet L., Thomas, Edward L., Swanson, Charles M., Goosen, Linda S., Sammartino, Gael, Gilliland, John C., Munshi, Nikhil C., Tricot, Guido, Shaughnessy, John D., Barlogie, Bart

“…Multicolour spectral karyotyping (SKY) was performed on primary tumour specimens from 100 patients with multiple myeloma (MM) that showed complex clonal…”
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De novo proximal duplication of 1(q12q22) in a female infant with multiple congenital anomalies by Sawyer, Jeffrey R., Binz, Regina Lichti, Swanson, Charles M., Lim, Cynthia

“…Reports of small proximal 1q duplications are rare. We report a 1 month‐old female who was referred to clinic because she was believed to have features…”
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Chromosome 1q12 Instability Drives Both 1q21 Amplification and Arm-Length Deletions in Multiple Myeloma by Sawyer, Jeffery R., Tian, Erming, Walker, Brian A, Swanson, Charles M., Lukacs, Janet L, Sammartino, Gael M., Bailey, Clyde, Thanendrarajan, Sharmilan, Schinke, Carolina D., Zangari, Maurizio, van Rhee, Frits, Davies, Faith E., Morgan, Gareth J.

“…Introduction Chromosome instability is a driver of copy number aberrations (CNAs) in cancer, and is a factor leading to tumor heterogeneity and resistance to…”
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Hyperhaploidy is a novel high-risk cytogenetic subgroup in multiple myeloma by Sawyer, J R, Tian, E, Shaughnessy Jr, J D, Epstein, J, Swanson, C M, Stangeby, C, Hale, C L, Parr, L, Lynn, M, Sammartino, G, Lukacs, J L, Stein, C, Bailey, C, Zangari, M, Davies, F E, Van Rhee, F, Barlogie, B, Morgan, G J

“…Hyperhaploid clones (24–34 chromosomes) were identified in 33 patients with multiple myeloma (MM), demonstrating a novel numerical cytogenetic subgroup…”
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Evidence for telomeric fusions as a mechanism for recurring structural aberrations of chromosome 11 in giant cell tumor of bone by Sawyer, Jeffrey R., Goosen, Linda S., Binz, Regina Lichti, Swanson, Charles M., Nicholas, Richard W.

“…Giant cell tumor of bone (GCTB) is a benign but often aggressive tumor with a tendency toward local recurrence. Telomeric associations (tas) or telomeric…”
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Recurring breakpoints of 1p13∼p22 in osteochondroma by Sawyer, Jeffrey R., Thomas, Edward L., Lukacs, Janet L., Swanson, Charles M., Ding, Yiling, Parham, David M., Thomas, James R., Nicholas, Richard W.

“…Cytogenetic studies of osteochondromas are scarce but have previously shown recurring clonal aberrations involving chromosome 8. We have studied a series of…”
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Chromosome instability in ICF syndrome: formation of micronuclei from multibranched chromosomes 1 demonstrated by fluorescence in situ hybridization by Sawyer, J R, Swanson, C M, Wheeler, G, Cunniff, C

“…We report on a new patient with immunodeficiency, centromeric heterochromatin instability, and facial anomalies (the ICF syndrome). Studies with traditional…”
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Evidence of an association between 6q13‐21 chromosome aberrations and locally aggressive behavior in patients with cartilage tumors by Sawyer, Jeffrey R., Swanson, Charles M., Lukacs, Janet L., Nicholas, Richard W., North, Paula E., Thomas, James R.

“…BACKGROUND The finding of a cytogenetic‐pathologic correlation between complex karyotypes and high grade cartilaginous tumors has been reported. However, few…”
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De novo proximal duplication of 1(q12q22) in a female infant with multiple congenital anomalies by Sawyer, Jeffrey R., Binz, Regina Lichti, Swanson, Charles M., Lim, Cynthia

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Recurring breakpoints of 1p13 approximately p22 in osteochondroma by Sawyer, Jeffrey R, Thomas, Edward L, Lukacs, Janet L, Swanson, Charles M, Ding, Yiling, Parham, David M, Thomas, James R, Nicholas, Richard W

“…Cytogenetic studies of osteochondromas are scarce but have previously shown recurring clonal aberrations involving chromosome 8. We have studied a series of…”
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A new reciprocal translocation (12;22)(q24.3;q11.2–12) in a malignant rhabdoid tumor of the brain by Sawyer, Jeffrey R., Goosen, Linda S., Swanson, Charles M., Tomita, Tadanori, de Leon, Guillermo A.

“…We report a malignant rhabdoid tumor (MRT) of the brain with a novel reciprocal translocation, t(12;22)(q24.3;q11.2–12). Previous reports of chromosome…”
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Telomeric fusion and chromosome instability in multiple tissues of a patient with mosaic Ullrich-Turner syndrome by Sawyer, Jeffrey R., Swanson, Charles M., Lukacs, Janet L., Hassed, Susan J., Curtis, Mary A., North, Paula E., Kozlowski, Karen J., Pihoker, Catherine

“…We describe the cytogenetic evolution of multiple cell lines in the gonadal tissue of a 10‐year‐old girl with mosaic Ullrich‐Turner syndrome (UTS) involving…”
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Cytogenetic findings in a case of pediatric glioblastoma by Sawyer, J R, Swanson, C M, Roloson, G J, Longee, D C, Chadduck, W M

“…We report a patient with glioblastoma multiforme (GBM) which showed stable and unstable telomeric associations involving the short arms of chromosomes 4 and 7…”
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Evolution of tumor chromosome abnormalities after therapy in a pediatric astrocytoma by Sawyer, J R, Swanson, C M, Chadduck, W M, Roloson, G J

“…Chromosome studies originally performed on a patient with an untreated pontine astrocytoma showed a trisomy for 1q as the sole chromosome aberration. After the…”
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Molecular cytogenetic analysis of a medulloblastoma with isochromosome 17 and double minutes by Sawyer, J R, Swanson, C M, Roloson, G J, Longee, D C, Boop, F A, Chadduck, W M

“…Cytogenetic analysis of a medulloblastoma revealed two abnormal cell lines of 48,XY, +8, +8, -14, +der(14)t(1;14)(q11;p11),i(17q) and 51,XY, +5, +6, +8, +8,…”
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