Search Results - "Swaney, James S."

Amelioration of dermal fibrosis by genetic deletion or pharmacologic antagonism of lysophosphatidic acid receptor 1 in a mouse model of scleroderma by Castelino, Flavia V., Seiders, Jon, Bain, Gretchen, Brooks, Sarah F., King, Christopher D., Swaney, James S., Lorrain, Daniel S., Chun, Jerold, Luster, Andrew D., Tager, Andrew M.

“…Objective Scleroderma (systemic sclerosis [SSc]), is characterized by progressive multiorgan fibrosis. We recently implicated lysophosphatidic acid (LPA) in…”
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Microtubules and Actin Microfilaments Regulate Lipid Raft/Caveolae Localization of Adenylyl Cyclase Signaling Components by Head, Brian P., Patel, Hemal H., Roth, David M., Murray, Fiona, Swaney, James S., Niesman, Ingrid R., Farquhar, Marilyn G., Insel, Paul A.

“…Microtubules and actin filaments regulate plasma membrane topography, but their role in compartmentation of caveolae-resident signaling components, in…”
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Inhibition of Cardiac Myofibroblast Formation and Collagen Synthesis by Activation and Overexpression of Adenylyl Cyclase by Swaney, James S., Roth, David M., Olson, Erik R., Naugle, Jennifer E., Meszaros, J. Gary, Insel, Paul A., Seegmiller, J. Edwin

“…Transformation of fibroblasts to myofibroblasts, characterized by expression of α-smooth muscle actin (α-SMA) and production of extracellular matrix (ECM)…”
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Impact of anesthesia on cardiac function during echocardiography in mice by Roth, David M, Swaney, James S, Dalton, Nancy D, Gilpin, Elizabeth A, Ross, Jr, John

“…Anesthetics provide sedation and immobility facilitating echocardiography in mice, but influence cardiac function. We studied the effects of intraperitoneal…”
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Increased smooth muscle cell expression of caveolin-1 and caveolae contribute to the pathophysiology of idiopathic pulmonary arterial hypertension by Patel, Hemal H, Zhang, Shen, Murray, Fiona, Suda, Ryan Y.S, Head, Brian P, Yokoyama, Utako, Swaney, James S, Niesman, Ingrid R, Schermuly, Ralph T, Pullamsetti, Soni Savai, Thistlethwaite, Patricia A, Miyanohara, Atsushi, Farquhar, Marilyn G, Yuan, Jason X.-J, Insel, Paul A

“…Vasoconstriction and vascular medial hypertrophy, resulting from increased intracellular [Ca²⁺] in pulmonary artery smooth muscle cells (PASMC), contribute to…”
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Caveolae and Lipid Rafts: G Protein-Coupled Receptor Signaling Microdomains in Cardiac Myocytes by INSEL, PAUL A., HEAD, BRIAN P., OSTROM, RENNOLDS S., PATEL, HEMAL H., SWANEY, JAMES S., TANG, CHIH-MIN, ROTH, DAVID M.

“…: A growing body of data indicates that multiple signal transduction events in the heart occur via plasma membrane receptors located in signaling microdomains…”
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Sphingosine-1-phosphate (S1P) is a novel fibrotic mediator in the eye by Swaney, James S., Moreno, Kelli M., Gentile, Angela M., Sabbadini, Roger A., Stoller, Glenn L.

“…Sphingosine-1-phosphate (S1P) is a pleiotropic lysolipid that has recently been implicated in the regulation of tissue fibrosis. However, the fibrogenic…”
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Focal Adhesions in (Myo)fibroblasts Scaffold Adenylyl Cyclase with Phosphorylated Caveolin by Swaney, James S., Patel, Hemal H., Yokoyama, Utako, Head, Brian P., Roth, David M., Insel, Paul A.

“…Fibroblast-myofibroblast transformation, a critical event for enhanced extracellular matrix deposition, involves formation of an actin stress fiber contractile…”
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Adenylyl cyclase increases survival in cardiomyopathy by ROTH, David M, BAYAT, Hamed, DRUMM, Jeffrey D, MEI HUA GAO, SWANEY, James S, ANDER, Aziz, HAMMOND, H. Kirk

“…To test the hypothesis that increased cardiac adenylyl cyclase type VI (AC(VI)) content, which results in increased cAMP generation, would increase survival in…”
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Sphingosine-1-phosphate and sphingosine kinase are critical for transforming growth factor-β-stimulated collagen production by cardiac fibroblasts by Gellings Lowe, Nicole, Swaney, James S., Moreno, Kelli M., Sabbadini, Roger A.

“…Aims Following injury, fibroblasts transform into myofibroblasts and produce extracellular matrix (ECM). Excess production of ECM associated with cardiac…”
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Progressive heart failure after myocardial infarction in mice by Bayat, Hamed, Swaney, James S., Ander, Aziz N., Dalton, Nancy, Kennedy, Brian P., Hammond, H. Kirk, Roth, David M.

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Adenylyl cyclase activity and function are decreased in rat cardiac fibroblasts after myocardial infarction by Swaney, James S, Patel, Hemal H, Yokoyama, Utako, Lai, N Chin, Spellman, Matthew, Insel, Paul A, Roth, David M

“…Myocardial infarction (MI) results in left ventricular remodeling (e.g., ventricular hypertrophy, dilatation, and fibrosis). Fibrosis contributes to increased…”
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Cardiac-directed expression of adenylyl cyclase and heart rate regulation by Roth, David M, Drumm, Jeffrey D, Bhargava, Valmik, Swaney, James S, Gao, Mei Hua, Hammond, H Kirk

“…Mice with cardiac-directed overexpression of AC(VI) show increased cardiac responsiveness to beta-adrenergic receptor stimulation but regulation of heart rate…”
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Angiotensin II Enhances Adenylyl Cyclase Signaling via Ca2+/Calmodulin by Ostrom, Rennolds S., Naugle, Jennifer E., Hase, Miki, Gregorian, Caroline, Swaney, James S., Insel, Paul A., Brunton, Laurence L., Meszaros, J. Gary

“…Cardiac fibroblasts regulate formation of extracellular matrix in the heart, playing key roles in cardiac remodeling and hypertrophy. In this study, we sought…”
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Sphingosine-1-phosphate and sphingosine kinase are critical for transforming growth factor-p-stimulated collagen production by cardiac fibroblasts: Lipid Signalling Pathways in the Heart and Vasculature by GELLINGS LOWE, Nicole, SWANEY, James S, MORENO, Kelli M, SABBADINI, Roger A

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cAMP promotes migration of cardiac fibroblasts via Epac and attenuates their transformation to myofibroblasts via PKA by Yokoyama, Utako, Patel, Hemal H, Swaney, James S, Roth, David M, Insel, Paul A

“…Background: Migration and transformation of fibroblasts (fib) to myofibroblasts (myofib) are key events in connective tissue remodeling. The role of cAMP in…”
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Progressive heart failure after myocardial infarction in mice by Bayat, Hamed, Swaney, James S, Ander, Aziz N, Dalton, Nancy, Kennedy, Brian P, Hammond, H Kirk, Roth, David M

“…We tested the hypotheses that myocardial infarction in mice would lead to progressively worsening heart failure 12-18 weeks later and that exercise testing…”
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Angiotensin II enhances adenylyl cyclase signaling via Ca2+/calmodulin. Gq-Gs cross-talk regulates collagen production in cardiac fibroblasts by Ostrom, Rennolds S., Naugle, Jennifer E., Hase, Miki, Gregorian, Caroline, Swaney, James S., Insel, Paul A., Brunton, Laurence L., Meszaros, J.Gary

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Angiotensin II enhances adenylyl cyclase signaling via Ca2+/calmodulin. Gq-Gs cross-talk regulates collagen production in cardiac fibroblasts by Ostrom, Rennolds S, Naugle, Jennifer E, Hase, Miki, Gregorian, Caroline, Swaney, James S, Insel, Paul A, Brunton, Laurence L, Meszaros, J Gary

“…Cardiac fibroblasts regulate formation of extracellular matrix in the heart, playing key roles in cardiac remodeling and hypertrophy. In this study, we sought…”
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Anti-fibrotic effects of adenylyl cyclase in the heart: Implications for connective tissue remodeling by cardiac fibroblasts by Swaney, James S

“…Cardiac fibroblasts (CF) are the most abundant cell type in the heart and are responsible for extracellular matrix (ECM) homeostasis and repair in response to…”
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